Showing 30 results for Gene
Feizi Ghader , Kaviani Naser , Mehrparvar Roza , Binandeh Elham Sadaat , Tabrizizadeh Mehdi , Saatchi Masoud ,
Volume 27, Issue 4 (1-2015)
Abstract
Background and Aims: Postoperativee endodontic pain is an outstanding problem for dental patients. Therefore, a successful management of endodontic pain has become as one of the main dental objectives. The aim of the present study was to compare the postoperative endodontic pain in patients under general anesthesia versus local anesthesia.
Materials and Methods: For conducting this clinical trial study, 50 patients having mandibular molars candidate for root canal therapy were selected. Twenty-five patients treated under general anesthesia because of their fear, anxiety or gag reflex. Other 25 patients treated under local anesthesia. All teeth were prepared using engine-driven rotary system in a crown-down technique and filled using lateral condensation technique. Heft- parker visual analog scale was used to measure the degree of pain at 6, 12, 24, and 48 hours after the treatment. Mann-Whitney, Chi-square, and T-tests were used to compare the intensity of postoperative pain between the groups.
Results: The mean intensity of postoperative pain in local and general anesthesia groups at 6, 12 and 24 hours had statistically significant difference (P<0.05).
Conclusion: Postoperative pain in patients who treated under general anesthesia was significantly less than the patients who treated under local anesthesia.
Akbari Majid , Makarem Abbas , Fazel Akbar ,
Volume 27, Issue 4 (1-2015)
Abstract
Background and Aims: The importance of quality in medical education makes the need for better standards in educational systems in the center of interest as the basis for certification. Standards needed to be evaluated by program administrators before the implementation phase. The purpose of this study was to evaluate the general dentistry standards program in Islamic republic of Iran from dental schools view point.
Materials and Methods: This descriptive study was performed during the year 2011 and 2012. A list of 16 faculties was introduced by the dental secretariat of the Ministry of Health and Medical Education. A check list was conducted based on the basic standards of undergraduate dental program that consisted of the importance and feasibility of each standard. The checklist was evaluated by sixteen dental schools representatives and asked their faculty members and reported back to the dental secretariat of the Ministry of Health. Results were reported in descriptive statistics manner.
Results: Data were collected from 14 dental schools. (Response rate=87%). All of the criteria were essential with more than 85% agreement of the faculties. There were more than 70% of criteria that were not feasible in less than one year.
Conclusion: The dental standard program was widely accepted by the faculties over the country. However, it seemed that by the faculties it would fail if used as accreditation base line.
Farzane Jabari, Behzad Houshmand, Saeed Hesaraki,
Volume 31, Issue 3 (11-2018)
Abstract
The Guided Bone Regeneration (GBR) treatment concept advocates that regeneration of osseous defects is predictably attainable via the application of occlusive membranes, which mechanically exclude non-osteogenic cell populations from the surrounding soft tissues, thereby allowing osteogenic cell populations originating from the parent bone to inhabit the osseous wound. The use of membrane to exclude non-osteogenic cells, is a key principle of guided bone regeneration. A large number of membranes have been evaluated in clinical and experimental studies. The object of this study was to review the literature regarding guided bone regeneration and all types of membranes that were used in this technique. 72 articles between the years 1968 through the 2016 from PubMed, Medline and Google Scholar using the related keywords, were selected. Finally, we concluded that the modification of mechanical and physico-chemical properties of membranes could improve the process of new bone growth. However, determination of the exact role of membrane porosity in this process, still needs to be clarified. Optimization the chemical composition of membrane with the focus and attention to obstructive property and bioactivity, is an important point in this research field. Various factors such as flexibility, mechanical strength and degradation rate determine the type of membrane used for bone tissue regeneration.
Mohammad Najafi, Hassan Semyari, Rokhsareh Sadeghi, Fatemeh Mashhadiabbas, Fereshteh Shanei,
Volume 32, Issue 3 (11-2019)
Abstract
Background and Aims: Reconstruction of osseous defects is one of the ideal goals of periodontal treatments and dental implant therapy. Different biomaterials have been used for this purpose and many studies have tried to compare and introduce the best ones. The present study aimed to evaluate the effect of PDFDB (Partially Demineralized Freeze-Dried Bone Graft) and FDBA (Freeze Dried Bone Allograft) on the regeneration of rabbit calvarial defects.
Materials and Methods: In this experimental study, 48 similar defects with the diameter of 8 mm were generated in the calvarium of 16 rabbits. Two defects were filled with FDBA and PDFDB, while the other one remained unfilled as the control group. All defects were covered by collagen membranes. 6 and 12 weeks after surgery, the histologic and histomorphometric tests were performed to evaluate the following variables: the rate of new bone formation and its type, the amount of residual grafting material, degree of inflammation and pattern of bone formation. Comparison of osteogenesis percentage and residual biomaterial was performed by repetitive variance analysis, whereas qualitative variables were compared by Friedman non-parametric test.
Results: Regarding bone formation percentage, there was no statistically significant difference between three different groups at 6-week (P=0.33) and also at 12-week time points (P=0.98). The amount of residual material in the PDFDB group was significantly lower than FDBA (P=0.04) in the 6-week samples. However, this difference was not significant in the 12-week samples (P=0.41). Bone quality showed statistically significant difference between graft containing groups and control group after 12 weeks (P=0.01). It means, all samples in FDBA and PDFDB groups displayed lamellar bone after 12 weeks while in control group, only woven bone or a combination of woven and lamellar bone was seen.
Conclusion: FDBA and PDFDB demonstrated similar regenerating effect in the rabbit calvarial bone defects and hastened bone maturation compared to the non-grafted defects.
Mohadese Baghdadchi, Elham Siasi Torbati, Kumars Amini,
Volume 33, Issue 1 (7-2020)
Abstract
Background and Aims: Periodontitis is one of the most common causes of damage to the gums and retaining structures of the teeth. Matrix protein, a metalloproteinase, is known as intermediate collagenase and the enzyme collagenase fibroblast, which is encoded in humans by the MMP-1 gene. The aim of this study was to investigate 1G/2G polymorphism in the MMP-1 gene and its association with the periodontal disease in the Iranian patients.
Materials and Methods: In this study, 50 patients with periodontal disease and 50 patients were selected as the control group in Kerman city. DNA was extracted from a person's blood sample using a kit. The desired primers were controlled by the NCBI site. Then, with the Tetra arms PCR technique, the desired polymorphism was multiplied. In the next step, the samples were transferred to electrophoresis gel and examined. The results were analyzed with SPSS software using T-test or Squer Chi-(X2).
Results: The percentage of 1G/1G genotype in the patients group was 8% and for the controls group was 0%. The percentage of 2G/2G genotype for the patients group was 24% and for the controls group was 18%. In addition, the 1G/2G genotype frequency was 68% for the patients group, and for the controls group was 82% (P=0.83). The results of Tetra-arms PCR genotyping of the samples were confirmed by sequencing.
Conclusion: The findings indicated that in Iranian patients, MMP-1 -1607 1G/2G (rs1799750) was not significantly associated with periodontal disease. It is recommended to take more samples from different parts of Iran to confirm the results.
Parisa Noohi, Mohammad Jafar Abdekhodaie, Mohammad Hossein Nekoofar, Prof. Paul Mh Dummer,
Volume 36, Issue 0 (5-2023)
Abstract
Background and Aims: Pulp necrosis in immature teeth disrupts root development and makes the teeth susceptible to fracture. Regenerative endodontics is a relatively new modality of treatment where the necrotic pulp is replaced with newly formed healthy tissue which has normal functionality. Many clinical reports have demonstrated the potential of this strategy to induce root maturation and apical closure. However, clinical outcomes are patient-dependent and unpredictable. Developing predictable protocols can be achieved through the interplay of three basic elements of tissue engineering, namely, scaffolds, stem cells, and signaling molecules. Furthermore, the clinical success of this treatment is influenced by both the method of preparing the inner space of the root and the type of biomaterial utilized in the coronal part. In this review, we discuss recent advances in tissue engineering-based strategies for regeneration of the pulp/dentine complex along with their advantages and limitations.
Maryam Rabiei, Dr Ideh Dadgaran, Ahmad Almoussavi, Saba Masoudirad, Sahba Khosousisani,
Volume 38, Issue 0 (4-2025)
Abstract
Background and Aims: Educational planning is one of the main areas of education and training, which plays an essential role in the optimal training of human resources. The aim of this study was to compare the educational program (curriculum) of general dentistry in Iran with that of several prestigious dental schools in the Middle East countries.
Materials and Methods: This is a descriptive comparative study using the dental education curricula of six prominent countries in the Middle East in the field of dental sciences. Their selection was based on similarities and common cultural, economic and social characteristics. After collecting the selected curriculums, four steps including description, interpretation, juxtaposition and comparison were done. Tables were drawn based on goals such as the number of years of education, mission, general goals, and the role of graduates in the medical system of that country.
Results: The educational curriculum of the countries reviewed in the Middle East have many similarities in terms of the number of years of study in the field of dentistry, the general mission and goals, and the role of students in the medical system of that country. The main differences were in the number and type of teaching units in the curriculum of this countries. The method of teaching and the distribution of topics in the curricula of the countries differentiated them from each other. According to the results of this study, the curriculum of the countries of Iran, Saudi Arabia and the UAE were the most similar among the countries of the Middle East. The teaching method and distribution of topics in the curricula of countries distinguished them from each other.
Conclusion: Countries that are based on Russian language education have a shorter number of years of education and are similar to Russia. However, countries with an American educational base such as Saudi Arabia, the United Arab Emirates, and even Iran have a longer academic years and more general similarities in educational content.
- Shaghayegh Kohzadi, Zahra Mohammadi,
Volume 38, Issue 0 (4-2025)
Abstract
Guided bone and tissue regeneration is a common technique used in the treatment of areas around teeth and dental implants. In this framework, barrier membranes are employed to create a suitable environment that promotes new bone growth while preventing the invasion of foreign cellular components into this specific setting. Attributes such as biocompatibility with living tissues, structural integrity, longevity, and user-friendliness constitute the principal criteria for selecting appropriate membranes for this particular application. Given the extensive diversity of membrane types concerning their sources, texture, architecture, and inherent properties, determining the most suitable variant depends on the clinical condition presented by the patient and the specific treatment modality, thereby emphasizing its considerable importance. In recent years, fibrous membranes have garnered particular attention due to their distinctive characteristics. These membranes, made of natural or synthetic fibers, typically exhibit high porosity, which facilitates the ingress of vascular structures and osteogenic cells. Owing to their porosity and flexibility, fibrous membranes are considered exceptionally suitable for the regeneration of maxillofacial and dental tissues, thereby contributing to increase bone volume, guide its growth, and at the same time prevent soft tissue encroachment into the restoration area, which ultimately has a favorable effect on treatment outcomes. On the other hand, due to the complexity and extent of oral infections, new nanotechnological approaches have been proposed in recent years to reconstruct infected sites in dentistry. These strategies, by targeting specific sites and having non-toxic properties, can help deliver antimicrobial molecules, regenerate tissue, and maintain oral health. In this context, nanofibrous membranes serve as multifunctional structures, both in the controlled release of antimicrobial agents and as scaffolds for the formation of nascent tissue. Overall, fibrous membranes, by mimicking the physiological conditions of the organism, create an ideal environment for the growth and healing of bone tissues, leading to improved effectiveness in dental procedures. This article is devoted in detail to a comprehensive review of polymeric and composite fibrous membranes with drug release potential.
Seyedreza Khosravani, Leila Azimi, Saeed Moghadamzarandi, Narges Panahandeh,
Volume 38, Issue 0 (4-2025)
Abstract
Background and Aims: To prevent dental caries, investigations have focused on finding new antibacterial and anti-biofilm agents without the drawbacks of the currently used synthetic agents. This study aimed to assess the effect of methanolic extract of Zingiber officinale (Z. officinale) on expression of virulence genes of Streptococcus mutans (S. mutans) using real-time polymerase chain reaction (PCR).
Materials and Methods: In this in vitro study, which was conducted in the year 1402, at the Microbiology Department of the Faculty of Medicine and the Faculty of Dentistry at Shahid Beheshti University of Medical Sciences, the methanolic extract of Z. officinale was obtained by the maceration technique. 10 clinical isolates of S. mutans were obtained from the patients with dental infection. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of the extract against S. mutans were determined by the microtiter plate technique. The effect of extract on the expression of relA, comDE, brpA, gtfC, and spaP virulence genes by the clinical isolates was evaluated by the real-time polymerase chain reaction (PCR) technique. Data were analyzed by the Wilcoxon and Mann-Whitney tests (alpha=0.05).
Results: The mean MIC and MBC of the methanolic extract of Z. officinale against S. mutans were 32±11.8 and 64±26.12 mg/mL, respectively. The extract caused down-regulation of relA, comDE, brpA, and gtfC by 50%, 40%, 70%, and 70%, respectively. It also caused 4 times reduction in expression of spaP gene.
Conclusion: The methanolic extract of Z. officinale caused significant down-regulation of gtfC, brpA, relA, comDE, and spaP genes, indicating its optimal efficacy to control the virulence of S. mutans.
Vahid Herandi, Fahimeh Rashidi Maybodi, Fatemeh Karamad,
Volume 39, Issue 0 (3-2026)
Abstract
Background and Aims: Given the rapid growth of digital technologies in dentistry, assessing dentists’ awareness and attitudes toward this transformation is essential. This study aimed to evaluate the awareness and attitudes of general dentists in Yazd-Iran toward digital dentistry in 2025.
Materials and Methods: In this descriptive-analytical study, 135 general dentists in Yazd-Iran were selected through convenience sampling. Data were collected via an online questionnaire including demographic information and the questions related to awareness and attitude. Dat were analyzed using SPSS version 27 and the statistical analysis tests were Mann-Whitney, Kruskal-Wallis, and Chi-square to examine the variables.
Results: A total of 59 men and 76 women with a mean age of 31.92 ± 7.87 years participated in the study. The mean knowledge score was 7.76 ± 2.77 out of 12. Higher knowledge and a more positive attitude were significantly associated with older age, longer work experience, and male gender (P<0.05). Overall, 74.1% of participants were unaware of the well-known CAD/CAM system, 74.8% were unfamiliar with digital implant software, and 60% did not have adequate knowledge of correct application of intraoral scanners. While, 81.5% reported an overall positive attitude, only 11.9% considered their knowledge to be aligned with modern digital technologies.
Conclusion: General dentists demonstrated a moderate level of awareness and the existing knowledge gaps warrant greater attention in both undergraduate and continuing education. Enhancing knowledge among specific groups-such as younger, less experienced, and female dentists—is essential. Significant differences in attitudes were observed according to the age, gender, and years of professional experience.
