Search published articles


Showing 26 results for Gene
A comparative study of pain following endodontic treatment under general anesthesia
Feizi Ghader , Kaviani Naser , Mehrparvar Roza , Binandeh Elham Sadaat , Tabrizizadeh Mehdi , Saatchi Masoud ,
Volume 27, Issue 4 (1-2015)
Abstract

  Background and Aims: Postoperativee endodontic pain is an outstanding problem for dental patients. Therefore, a successful management of endodontic pain has become as one of the main dental objectives. The aim of the present study was to compare the postoperative endodontic pain in patients under general anesthesia versus local anesthesia.

  Materials and Methods: For conducting this clinical trial study, 50 patients having mandibular molars candidate for root canal therapy were selected. Twenty-five patients treated under general anesthesia because of their fear, anxiety or gag reflex. Other 25 patients treated under local anesthesia. All teeth were prepared using engine-driven rotary system in a crown-down technique and filled using lateral condensation technique. Heft- parker visual analog scale was used to measure the degree of pain at 6, 12, 24, and 48 hours after the treatment. Mann-Whitney, Chi-square, and T-tests were used to compare the intensity of postoperative pain between the groups.

  Results: The mean intensity of postoperative pain in local and general anesthesia groups at 6, 12 and 24 hours had statistically significant difference (P<0.05).

  Conclusion: Postoperative pain in patients who treated under general anesthesia was significantly less than the patients who treated under local anesthesia.


Evaluation of basic standards in the general dentistry teaching program approved in Islamic Republic of Iran from dental schools viewpoint
Akbari Majid , Makarem Abbas , Fazel Akbar ,
Volume 27, Issue 4 (1-2015)
Abstract

  Background and Aims: The importance of quality in medical education makes the need for better standards in educational systems in the center of interest as the basis for certification. Standards needed to be evaluated by program administrators before the implementation phase. The purpose of this study was to evaluate the general dentistry standards program in Islamic republic of Iran from dental schools view point.

  Materials and Methods: This descriptive study was performed during the year 2011 and 2012. A list of 16 faculties was introduced by the dental secretariat of the Ministry of Health and Medical Education. A check list was conducted based on the basic standards of undergraduate dental program that consisted of the importance and feasibility of each standard. The checklist was evaluated by sixteen dental schools representatives and asked their faculty members and reported back to the dental secretariat of the Ministry of Health. Results were reported in descriptive statistics manner.

  Results: Data were collected from 14 dental schools. (Response rate=87%). All of the criteria were essential with more than 85% agreement of the faculties. There were more than 70% of criteria that were not feasible in less than one year.

  Conclusion: The dental standard program was widely accepted by the faculties over the country. However, it seemed that by the faculties it would fail if used as accreditation base line.


The role of barrier membranes in guided bone regeneration; A review
Farzane Jabari, Behzad Houshmand, Saeed Hesaraki,
Volume 31, Issue 3 (11-2018)
Abstract
The Guided Bone Regeneration (GBR) treatment concept advocates that regeneration of osseous defects is predictably attainable via the application of occlusive membranes, which mechanically exclude non-osteogenic cell populations from the surrounding soft tissues, thereby allowing osteogenic cell populations originating from the parent bone to inhabit the osseous wound. The use of membrane to exclude non-osteogenic cells, is a key principle of guided bone regeneration. A large number of membranes have been evaluated in clinical and experimental studies. The object of this study was to review the literature regarding guided bone regeneration and all types of membranes that were used in this technique. 72 articles between the years 1968 through the 2016 from PubMed, Medline and Google Scholar using the related keywords, were selected. Finally, we concluded that the modification of mechanical and physico-chemical properties of membranes could improve the process of new bone growth. However, determination of the exact role of membrane porosity in this process, still needs to be clarified. Optimization the chemical composition of membrane with the focus and attention to obstructive property and bioactivity, is an important point in this research field. Various factors such as flexibility, mechanical strength and degradation rate determine the type of membrane used for bone tissue regeneration.

The effect of freeze-dried bone allograft and partially demineralized freeze-dried bone allograft on regeneration of rabbit calvarial bone defects: A Histological and histomorphometric study
Mohammad Najafi, Hassan Semyari, Rokhsareh Sadeghi, Fatemeh Mashhadiabbas, Fereshteh Shanei,
Volume 32, Issue 3 (11-2019)
Abstract
Background and Aims: Reconstruction of osseous defects is one of the ideal goals of periodontal treatments and dental implant therapy. Different biomaterials have been used for this purpose and many studies have tried to compare and introduce the best ones. The present study aimed to evaluate the effect of PDFDB (Partially Demineralized Freeze-Dried Bone Graft) and FDBA (Freeze Dried Bone Allograft) on the regeneration of rabbit calvarial defects.
Materials and Methods: In this experimental study, 48 similar defects with the diameter of 8 mm were generated in the calvarium of 16 rabbits. Two defects were filled with FDBA and PDFDB, while the other one remained unfilled as the control group. All defects were covered by collagen membranes. 6 and 12 weeks after surgery, the histologic and histomorphometric tests were performed to evaluate the following variables: the rate of new bone formation and its type, the amount of residual grafting material, degree of inflammation and pattern of bone formation. Comparison of osteogenesis percentage and residual biomaterial was performed by repetitive variance analysis, whereas qualitative variables were compared by Friedman non-parametric test.
Results: Regarding bone formation percentage, there was no statistically significant difference between three different groups at 6-week (P=0.33) and also at 12-week time points (P=0.98). The amount of residual material in the PDFDB group was significantly lower than FDBA (P=0.04) in the 6-week samples. However, this difference was not significant in the 12-week samples (P=0.41). Bone quality showed statistically significant difference between graft containing groups and control group after 12 weeks (P=0.01). It means, all samples in FDBA and PDFDB groups displayed lamellar bone after 12 weeks while in control group, only woven bone or a combination of woven and lamellar bone was seen.
Conclusion: FDBA and PDFDB demonstrated similar regenerating effect in the rabbit calvarial bone defects and hastened bone maturation compared to the non-grafted defects.

Association study between (rs1799750) polymorphism and periodontal by Tetra arms-PCR
Mohadese Baghdadchi, Elham Siasi Torbati, Kumars Amini,
Volume 33, Issue 1 (7-2020)
Abstract
Background and Aims: Periodontitis is one of the most common causes of damage to the gums and retaining structures of the teeth. Matrix protein, a metalloproteinase, is known as intermediate collagenase and the enzyme collagenase fibroblast, which is encoded in humans by the MMP-1 gene. The aim of this study was to investigate 1G/2G polymorphism in the MMP-1 gene and its association with the periodontal disease in the Iranian patients.
Materials and Methods: In this study, 50 patients with periodontal disease and 50 patients were selected as the control group in Kerman city. DNA was extracted from a person's blood sample using a kit. The desired primers were controlled by the NCBI site. Then, with the Tetra arms PCR technique, the desired polymorphism was multiplied. In the next step, the samples were transferred to electrophoresis gel and examined. The results were analyzed with SPSS software using T-test or Squer Chi-(X2).
Results: The percentage of 1G/1G genotype in the patients group was 8% and for the controls group was 0%. The percentage of 2G/2G genotype for the patients group was 24% and for the controls group was 18%. In addition, the 1G/2G genotype frequency was 68% for the patients group, and for the controls group was 82% (P=0.83). The results of Tetra-arms PCR genotyping of the samples were confirmed by sequencing.
Conclusion: The findings indicated that in Iranian patients, MMP-1 -1607 1G/2G (rs1799750) was not significantly associated with periodontal disease. It is recommended to take more samples from different parts of Iran to confirm the results.

Overview of recent advances in pulp/dentine complex tissue engineering
Parisa Noohi, Mohammad Jafar Abdekhodaie, Mohammad Hossein Nekoofar, Prof. Paul Mh Dummer,
Volume 36, Issue 0 (5-2023)
Abstract
Background and Aims: Pulp necrosis in immature teeth disrupts root development and makes the teeth susceptible to fracture. Regenerative endodontics is a relatively new modality of treatment where the necrotic pulp is replaced with newly formed healthy tissue which has normal functionality. Many clinical reports have demonstrated the potential of this strategy to induce root maturation and apical closure. However, clinical outcomes are patient-dependent and unpredictable. Developing predictable protocols can be achieved through the interplay of three basic elements of tissue engineering, namely, scaffolds, stem cells, and signaling molecules. Furthermore, the clinical success of this treatment is influenced by both the method of preparing the inner space of the root and the type of biomaterial utilized in the coronal part. In this review, we discuss recent advances in tissue engineering-based strategies for regeneration of the pulp/dentine complex along with their advantages and limitations. 

Page 2 from 2     

© 2024 , Tehran University of Medical Sciences, CC BY-NC 4.0

Designed & Developed by: Yektaweb