Arash Azizi, Samira Shah Siah, Asma Madhani,
Volume 25, Issue 1 (4-2012)
Abstract
Background and Aims: Recurrent aphthous stomatitis (RAS) is the most common oral mucosal inflammatory disease. The frequency of RAS is as much as 20% in the general population. The cause of RAS is not yet fully understood. Antioxidant is a material which has ability to preserve molecules from damage and also can delay the start of it. The aim of this study was to compare saliva level of total antioxidant status (TAS) in RAS patients with that of normal subjects.
Materials and Methods: In this case-control study, 25 patients with aphthous stomatitis were considered as the case group and 25 healthy subjects as control group. The case and control groups were matched by sex and age. Total antioxidant status (TAS) saliva levels were measured in two groups by spectrophotometer. The data were analyzed with independent sample t-test.
Results: The mean and standard deviation of TAS in case group was 1.64±0.64 µmol/L and in control group was 1.49±0.3 µmol/L. There was not significant difference between case and control groups (P=0.464).
Conclusion: Results of this study showed that there was no statistically significant difference between RAS patients and healthy subjects in saliva antioxidant status levels.
Mehryari Mahsa , Mortazavi Nazanin , Sayyadi Fatemeh , Mohsenitavakoli Saman , Zahedpasha Shaghayegh , Mortazaviamiri Seyedhadi , Bijani Ali , Kazemi Hamed Hossein , Motallebnejad Mina ,
Volume 27, Issue 4 (1-2015)
Abstract
Background and Aims: The purpose of the present study was to review the studies regarding serological and salivary oxidant / antioxidant status in patients with recurrent aphthous stomatitis (RAS).
Materials and Methods: The literature was searched using key words RAS, Antioxidants, Saliva, Hematinic (s) and Hematinic Acid in the last 10 years, particularly the recent 3 years (2010-2013). At total of 37 clinical trials, 18 case-control articles were selected and evaluated fulfilling the requirements as the RAS patients having at least 3 oral aphthous attack per year. The exclusion criteria included systemic as well as periodontal diseases, iron deficiency associated anemia, medication usage and smoking.
Conclusion: Almost all lipid-peroxidation studies in serum and saliva were manifested by an increase of malondialdehyde (MDA) concentration in RAS patients compared with controls. This would indicate the role of reactive oxygen species (ROS) in the etiology of the disease. Serum trace elements (Zn, Se) were reduced and Cu was increased in RAS patients in comparison with control individuals. A decreased serum superoxide dismutase (SOD) and an increased salivary SOD were observed in all RAS patients. Catalase (CAT) and uric acid (UA) analyses were non-inclusive. Levels of paraoxonase and arylesterase as well as antioxidant vitamins (A, E, C) were lower in RAS patients than that of controls.
Nazanin Kamyab, Mahmood Sheikh Fathollahi, Azadeh Khaleghi, Zohreh Mordouei,
Volume 32, Issue 3 (11-2019)
Abstract
Background and Aims: Saliva is the first body fluid that is exposed to the free radicals found in cigarette smoke. Antioxidant substances in saliva, such as vitamin C, play an important role in the defense mechanism against free radicals. Therefore, the aim of this study was to examine the effect of vitamin C on the total antioxidant capacity of saliva in smokers.
Materials and Methods: This randomized clinical trial was performed on 60 healthy male smokers who referred to the dental clinic in Rafsanjan in 2017. Individuals were randomly divided into three groups. The first and second groups received 500 and 1000 mg of vitamin C boiling tablets for three weeks. The third group did not receive any vitamin C supplements. The total antioxidant capacity of saliva was measured using an antioxidant kit and an ELISA reader. Data were analyzed using paired t-test, one-way ANOVA, and Duncan's multiple comparisons test.
Results: The results showed that the mean total antioxidant capacity of saliva after the intervention was found statistically significant among groups (P<0.001). However, the mean total antioxidant capacity of saliva did not differ in the groups receiving 500 and 1000 mg of vitamin C (P=0.420).
Conclusion: The results showed that taking vitamin C increased the total antioxidant capacity of saliva in smokers.
