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Showing 3 results for Aphthous
Evaluation of serum immonogiobulins (A,G,M) and complement components (C3 d) in Isfahan dental clinics patients with recurrent aphlus stomatitis
P. Ghalayani Isfahani , B.  khorami ,
Volume 13, Issue 3 (10-2000)
Abstract
Recurrent aphtus stomatitis (RAS) is an oral mucous lesion in patients with no other signs of disease. Investigators have always notified the role of immune system especially humoral immunity in aphtus immunopathogenesis. The aim of this case-controlled study was to measure amount of serum immonogiobulins (A,G,M) and complement component (C3 C4) in patients with RAS and to evaluate any relation between differences in these factors and pathogenesis of RAS. Immonogiobulins (A,G,M) and complement components (C3 C4) of 50 patients with RAS was measured using single radial immuno diffusion technique. The results were compared with immonogiobulins (A,G,M) and complement components (C3 C4) of 50 healthy people whom were similar in age and sex with the patients group. Results showed that the patients group had higher level of IgA and IgM while serum IgG was similar in both groups. The C3 was lower in aphtus patients while no significant difference was found in amount of C4. The sex had no significant effect on serum level of measured factors. From the results it can be concluded that the humoral immunity reaction has an important role in immunopathogenesis of RAS. This humoral response might accurse as a result of cellular immunity reaction.
HLA typing in patients with recurrent aphthous stomatitis
A. Taghavi Zenouz , R. Sobuti , Sh. Jafari , B. Nikbin ,
Volume 16, Issue 4 (1-2004)
Abstract

Statement of Problem:Recurrent aphthous stomatitis (RAS) is a common oral disorder that despite extensive researches, the etiology of this phenomenon is still unknown. Because this phenomenon has been observed more often in families than in individual cases, genetic influence has been investigated in most researches.
Purpose: The aim of the present study was to evaluate the association between Human Leukocyte Antigen (HLA) and aphthous stomatitis more precisely.
Materials and Methods: in this study, 60 patients with RAS were examined for HLA-A and HLA- B types and 37 of them were examined for HLA- DR and HLA-DQ types. The results were compared through Fisher test with those of 25 healthy control subjects, aged more than 30 years.
Results: A significant decrease in the frequency of some antigens such as HLA-DQW 3 and HLA-A 26 in subjects with RAS was observed. Therefore, according to the results of this study, these antigens were considered as resistant antigens to recurrent aphthous stomatitis. In contrast, there was no significant increase in the frequency of any HLA antigens in the test group, compared to the control group. This finding is in contrast with the multiple reports about Behcet's disease. (Because a high frequency of HLA-B 51 has been
found in Behcet's syndrome.)

Conclusion: According to the findings of this study, it is suggested that the pathogenicity of aphthous ulcerations in Behcet's disease and recurrent aphthous stomatitis is not the same. However, further studies are necessary to prove this theory.


Comparison of amount of salivary total antioxidant in patients with recurrent aphtous stomatitis
Arash Azizi, Samira Shah Siah, Asma Madhani,
Volume 25, Issue 1 (4-2012)
Abstract

Background and Aims: Recurrent aphthous stomatitis (RAS) is the most common oral mucosal inflammatory disease. The frequency of RAS is as much as 20% in the general population. The cause of RAS is not yet fully understood. Antioxidant is a material which has ability to preserve molecules from damage and also can delay the start of it. The aim of this study was to compare saliva level of total antioxidant status (TAS) in RAS patients with that of normal subjects.

Materials and Methods: In this case-control study, 25 patients with aphthous stomatitis were considered as the case group and 25 healthy subjects as control group. The case and control groups were matched by sex and age. Total antioxidant status (TAS) saliva levels were measured in two groups by spectrophotometer. The data were analyzed with independent sample t-test.

Results: The mean and standard deviation of TAS in case group was 1.64±0.64 µmol/L and in control group was 1.49±0.3 µmol/L. There was not significant difference between case and control groups (P=0.464).

Conclusion: Results of this study showed that there was no statistically significant difference between RAS patients and healthy subjects in saliva antioxidant status levels.


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