Showing 10 results for Cancer
M. Ghavam ,
Volume 14, Issue 2 (8-2001)
Abstract
Oral cancers account for a relatively high percent of neoplasms in the elderly population. Treatment protocols often include anti-neoplastic pharmaco-therapeutics, irradiation of the head and neck region, and surgery. These treatments, specially radiation, have detrimental effects on oral hard and soft tissues. Salivary glands undergo a distinct and longterm dysfunction, which leads to decrease in salivary How. Xerostomia is a common clinical problem in these patients which contributes to dry mouth, mucosites, change in oral ecosystem and dental caries, followed by difficulties in speech, swallowing and use of dentures which cause malnutrition. This phenomenon has an irreversible weakening effect on the patient's health. To prevent this negative impact on oral health in this group of patients, definitive dental treatments prior to the initiation of medical therapies is imperative, and will decrease the morbidity rates. Today's dentistry benefits from improved methods and materials, which enable us to give these patients a better preventive dental treatment. Consultation between dentist and medical team would be the best way to help our sufferer patients.
N. Eshghyar , M. Bateby ,
Volume 14, Issue 2 (8-2001)
Abstract
Different methods can be used to treat the malignant disease surgery, radiotherapy, chemotherapy, and even cryotherapy are different approach to reach the best treatment for patients. The aim of this cross sectional study was to evaluate the prevalence of oral side effects followed by chemotherapy of cancerous patients in Imam Khomeini hospital. This study was conducted on 80 patients who were under chemotherapy more than once and their oral lesions were evaluated considering their physical conditions. Mucositis was the common problem (66.2%) and the most involvement area was observed in tongue (55%). High percentage of this lesion in adult and senile might be due to deficiency in their immune system.
Mh. Ansari ,
Volume 15, Issue 4 (1-2003)
Abstract
Cancer is considered as one of human's complications, particularly in oral and maxillofacial region which leads to undesirable effects and sometimes endangers individual's life. The aim of this study was to investigate the frequency of maxillofacial malignant tumors, during 13 years, (1985- 1998),in Hamedan. Three hundred and eighty - six records of biopsies were selected from the private files of physicians, 7 private and governmental pathological centers and other educational and research organizations in Hamedan. After observing the samples by oral pathologist, they were presented as the statistical population for this retrospective study. The highest rate of biopsies was observed in the sixth (42.7%), seventh (39.6%) and third (10.6%) decades. The average age was 43.5 years, for women and 1.52 45.5 for men. The ratio of men to women was . The oldest patient was a 91- year - old man with malignant melanoma, while the youngest was a 3-year-old girl with Burkit lymphoma. The commonest site of involvement was nasal region (17.3%) and the anterior neck triangle showed the least common tumoral site (2.3%). The commonest tumor, observed in this study, was BBC (41.4%) and the least common was malignant fibrous histocytoma (0.2%). Baso cellular and epidermoid carcinomas have been the commonest cancers in this investigation, while lymphoma and salivary galnd cancers have been placed as the second ones. The results of this study showed that the lower lip and tongue are considered as the commonest sites for cancer.
Sayed Mohamad Razavi, Behzad Zolfaghari, Bahareh Tahani, Mostafa Emami Doost, Mehrdad Forohande,
Volume 27, Issue 1 (4-2014)
Abstract
Background and Aims : Dentists have usually a critical role in diagnosing oral cancer lesions in their early stages. In this study we aimed to assess the senior dental student’ and dentists’ knowledge, attitude and behaviors regarding oral cancer in Isfahan.
Materials and Methods: A valid and reliable self-administered questionnaire was designed to assess the current practice, knowledge and attitude of general dentists working in Isfahan-Iran and senior dental students regarding oral cancer lesions. The questionnaire was consisted of questions to assess the knowledge and attitude regarding diagnosis, risk factors and prognosis of oropharyngeal cancerous lesions. The frequencies of answers to questions in sections of practice and attitude (just for dentists) and sum score of questions in knowledge section were calculated and compared using statistical analysis regarding age, sex, duration of experience and practice setting ) p ublic/private) of participants. Data were analyzed using ANOVA, chi-square, linear regression and logistic regression.
Results: 139 questionnaires from dentists and 57 questionnaires from students were returned. The mean score of dentists’ knowledge was 5.41 out of 13 (CI95%=5.03-7.79 ). Significant differences were observed among dentists regarding their experience (P=0.001). Only one fifth of the dentists in our survey reported to perform oral cancer examination for all of their patients in age of 40 and above and just about 34% of dentists gained acceptable level of knowledge. Among senior dental students, the status of knowledge was better as about 58% of them gained the level of acceptance (P=0.01).
Conclusion: Although dentists were willing to follow the diagnostic protocol for oral cancer, they were mostly unsatisfied with the level of their knowledge. Therefore, this study highlights the need for educational planning and training activities in general dentists with regard to the risk factors and early detection of oral cancers.
Sayed Mohsen Hosseini, Fateme Bagheri, Faranak Farahmand, Asiye Heydari, Elahe Khorasani,
Volume 29, Issue 4 (1-2017)
Abstract
Background and Aims: Nowadays, oral cancer is considered one of the most important diseases related to oral health. The objective of the present study was to determine the dental students’ knowledge in Isfahan about oral cancer and the comparison of the level of students' knowledge in different years of education.
Materials and Methods: The present study was a cross-sectional-analytical one conducted in 2013. The population of study included the dental students of private and state University of Isfahan which 255 students were randomly selected. The data were collected using questionnaire and were then analyzed using SPSS software program and Kruskal-Wallis and Mann-Whitney.
Results: From private and public dental schools in Isfahan, 56% and 44% of dental students were involved. Regarding performing routine clinical oral examination, 81% of the participants answered positively, which showed no significant difference among the years of education of the participants (P=0.116). Regarding the examination of patients with oral lesions, 46% of them answered positively, which the difference between the years of education was highly significant (P≤0.001).
Conclusion: The findings of the research indicated that the level of knowledge of dental students of Isfahan city regarding the detection of oral lesions was not sufficient. Although, the students did not perform common examinations for exploring oral cancer, they did not have sufficient knowledge regarding some of the risk factors and oral lesions related to cancer. Therefore, it is necessary that a comprehensive curriculum be developed in this regard for their education.
Ahmad Jafari, Narges Gholizadeh, Rashid Ramezani, Hanie Emami Razavi, Shamsolmoulouk Najafi,
Volume 30, Issue 2 (8-2017)
Abstract
Background and Aims: Cancer is the second most common cause of death in developed countries. The goal of this study was to determine the important epidemiologic factors affecting diagnosis and survival rate of patients with laryngeal SCC, for prevention, control and increase longevity.
Materials and Methods: In this study, all the cases recorded at the Center of Cancer Office of the Iran Ministry of Health in Tehran between 2005-2009 were examined. From 513 cases, 279 that their follow-up was possible by phone or postal address were included in the study. Data collection were performed from questionnaire. The data were analyzed by SPSS version 20. The Kaplan Meier survival curves were utilized and, moreover, the corresponding influential factors were examined by using the Cox regression test.
Results: The mean age of patients were 61.1 years (SD=10.54). The gender of 92.1% of patients were male. The most widely used method for the treatment was a combination of three methods of surgery, radiation therapy, and chemotherapy. The overall five-year survival rate was 75.7% (SD=0.03). The gender, histological differentiation, and professional delay did not exhibit a statistical correlation with the survival rate (P=0.38, 0.14, 0.52), whereas the age and patient delay had a statistically significant relation with the survival rate (P=0.03, 0.07).
Conclusion: The survival rate was lower in older patients. Patient and professional delays were high, which need more attention for improving the quality of life.
Katayoun Sargeran, Amir Jalal Abbasi, Faegheh Fazeli,
Volume 30, Issue 2 (8-2017)
Abstract
Background and Aims: In modern societies, the incidence of oral cancer is increasing. It may be due to the increased population, life expectancy, and exposure to risk factors. This increase can particularly be seen in women and in our own country, Iran. The aim of the present study was to explore the status of care and treatment of patients with oral cancer referring to Shariati educational hospital in Tehran, during the years 2003-2013.
Materials and Methods: The present study was a cross-sectional descriptive survey on oral cancer patients attending the Shariati hospital in Tehran during a ten-year period. Data were collected through patient records and statistically analyzed by SPSS21 software.
Results: Regression analysis was performed in 5 models, where variables such as age, gender, location of the tumor, stage and grade was entered as independent variables and delay in treatment (time interval from diagnosis to treatment) entered as the dependent variable. The analysis showed that the elapsed time from diagnosis to treatment had a positive association with age of the patients. It means that the higher the age, the more delay in treatment (P<0.05). No relationship was found between the treatment delay and gender, tumor location, grade, and stage.
Conclusion: Considering the consequences of oral cancer for patients, there was necessity to formulate plans for preventing, early detection and improving quality of life in oral cancer patients.
Molook Torabi Parizi, Mahsa Kalantari, Farshad Ghavidel,
Volume 31, Issue 2 (9-2018)
Abstract
Background and Aims: Cancer is the 3rd cause of death after heart disease and injuries in Iran. Radiotherapy and chemotherapy are the most effective procedures in cancer therapy, but their side effects are still unknown for many patients. The main goal of this study was to evaluate the patients’ knowledge with head and neck cancer regarding the complications of radiotherapy and chemotherapy.
Materials and Methods: This descriptive-analytical research was based on the information extracted from personal questionnaires and files of cancer patients who referred to the centers of Kerman University of Medical Sciences during a 6 months period in 2017. The data were analyzed by chi-square test at the significance level of 0.05.
Results: Our findings showed that most of the patients (76.48%) had low information level. There was no statistically significant association between the knowledge with demographic variables (P>0.05). However, patients with chronic disease had higher level of information. Only 10% of patients had received information by their physicians.
Conclusion: It seems there is not effective education regarding the rated radiotherapy and chemotherapy complications, because their knowledge was not in acceptable level. Considering the importance of this issue, it is necessary to perform educational program to improve patients' ability and skills to cope whit the chemotherapy and radiotherapy complications and their side effects.
Ali Dehghani Nazhvani, Mahboobeh Razmkhah, Amirreza Jassbi, Mohammadreza Khademalizadeh, Afsoon Mahmoodi,
Volume 32, Issue 4 (1-2020)
Abstract
Background and Aims: Oral squamous cell carcinoma (OSCC) is one of the most prevalent oral cancers with increased risk in individuals younger than 40 years especially in developed countries. There are many evidences that people who have plenty of fruits and vegetables in their diets tend to have lower risk of cancer. In this study, we evaluated the anticancer effect of four medicinal plants of Otostegia Persica, Otostegia Michauxii, Otostegia Aucheri, and Hibiscus Sabdariffa on OSCC cell lines.
Materials and Methods: In this study, methanolic & dichloromethane extracts of the above medicinal plants were used in order to evaluate their effect on oral squamous cell carcinoma cell line in different concentrations and after 24 , 48 and 72 hrs by MTT assay test. Finally, the appropriate concentration for repeating the test were chosen.
Results: In this study, the mean amounts of IC50 for O. persica and O. Aucheri were less than the two other herbs and the least and most amount of IC50 were related to the dicloromethanolic extract of O. persica after 72 hrs and the water extract of H. sabdariffa after 24 hrs, respectively.
Conclusion: It was concluded that all of the plants evaluated especially O.Persica and O.Aucheri had anticancer properties and dichloromethalonic extracts of these plant were more effective than that of methanolic extract.
Pegah Palizban, Neda Kargahi, Forouz Keshani,
Volume 33, Issue 2 (8-2020)
Abstract
Background and Aims: Pre-cancerous lesions of the oral mucosa as important malformation need acceptable knowledge of dentists. The purpose of this study was to determine the knowledge of Isfahan city general dentists about pre-cancerous lesions of oral cavity.
Materials and Methods: This descriptive cross-sectional study based on validated questioner form was performed in 115 general dentists in Isfahan City in 2019, associated with sex and year of graduation from general dentistry course. The mean score was in the range from 0 to14. Data were recorded in Microsoft Excel and then analyzed by SPSS. In order to compare quantitative variables, independent T–Test, One-Way ANOVA and Mann-Whitney was used. P≤0.05 was considered as significant.
Results: The mean age in the participants of: lower than 5 years, between 5-10 years, and more than 10 years of graduation were 28.6±4.9, 30.6±4.0 and 47.9±10 years old, respectively. In total population, the mean score of knowledge was 5.97±2.79. There was not any significant difference between the mean score of knowledge in women when compared to men (5.96±2.99 versus 5.98±2.6; P=0.58). The mean knowledge score in the participants of: lower than 5 years, between 5-10 years, and more than 10 years, of graduation were as follow: 7.8±2.2 versus 5.8±2.9 versus 4.4±2.1, correspondingly (P≤0.05).
Conclusion: For the early diagnosis of pre-cancerous lesions of the oral cavity, retraining program based on oral cavity pathology courses is recommended for the dentists in Isfahan city.
