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Showing 7 results for Lichen Planus
An Epidemiologic study of lichen planus and direct inimunofluorescent on staining on it's paraffin sections
M. Eslami , K.  i'ayaz Moghadam , Sh. Shahrabi ,
Volume 12, Issue 2 (9-1999)
Abstract

Frequently, diagnosis of lichen planus as a relative common chronic inflammatory mucocutaneous disease, is difficult, therefor, direct Immunofluorescence (DIF) examination is recommended for definite diagnosis. In this study both an statistical analysis of files of oral and maxillofacial pathology department of Dentistry school and direct immunofluorescence examination using paraffin blocks with new method, were performed. According to analysis of 8026 cases, 262 (3.26%) cases were diagnosed as lichen planus most patients were in fourth decade of their life and most common affected region was buccal mucosa, (69.68%).
In direct immunofluorescence study of 14 cases (using firth's method) fibrinogen deposits in 6 cases and immunostaining of colloid bodies with various immunoglobulins (IgA, IgG, IgM), C3 and also fibrinogen (few values) in most of patients, were detected. In spite of the fact that density of staining was lower than routine method (using fresh-frozen tissue), except for fibrinogen immunostaining, these findings are compatible with previous studies. In spile of limitation of samples, this study suggests that using this technique needs more evaluation and this can be used for diagnosis purposes when fresh-frozen tissue is unavailable.


Evaluation of Serum TNF-a in Patients with Oral Keratotic Lichen Planus and Comparing with Healthy Cases
Sh. Jafari , M. Khatibi ,
Volume 13, Issue 1 (4-2000)
Abstract

: Oral lichen planus (OLP) is a chronic and common disease of the oral mucosa, which its etiology, phathogenesis and exact treatment is not definitely known. T-cell mediated immunity is the most probable factor in pathogenesis of OLP. Since TNF-a primarily, as a cytokine, interfers T-Cel mediated immunopathologic reactions, it may also interfere with pathogenesis of OLP.In an observational case- control study, the values of TNF-a in serum of OLP patients were measured and compared with the values of healthy cases. 30 OLP patients and 30 healthy controls have examined with ELISA technique. Data was obtained by observation questionnaire and examination.The mean value of TNF-a in case and control groups were 26.2 and 7.9 pg/ml, respectively, which showed significant difference (PO.005).Considering the TNF-a values with respect to sex and age did not show any significant difference,however the lower TNF-a value was obtained with increasing the age, and higher value observed in females. Higher values of TNF-a found in OLP patients compared with control group. It means TNF-a is an effective factor in OLP. Due to these findings new treatment protocols have been suggested.


A retrospective study of oral lichen planus in oral pathology department, Tehran University of Medical Sciences (1968-2002)
M. Khalili , M. Shojaee ,
Volume 19, Issue 3 (6-2006)
Abstract

Background and Aim: Oral lichen planus is a chronic mucocutaneous disease with various clinical expressions. The histopathologic features are not characteristic and may be seen in other diseases. The aim of this study was to determine the clinical and pathologic features of oral lichen planus in oral pathology department of dental school, Tehran university of medical sciences.

Materials and Methods: In this case series study, archive of oral pathology department from 1968 to 2002 was reviewed and cases diagnosed as lichen planus and related lesions selected. The diagnosis of oral lichen planus was confirmed by evaluation of microscopic slides. Clinical informations such as age, sex, site and duration of lesions and differential diagnosis as well as microscopic findings were recorded. Data were analyzed with SPSS software using t student, ANOVA, Chi-square and Post Hoc Tukey tests with p<0.05 as the limit of significance.

Results: From a total of 402 cases recorded as lichen planus and related lesions, 251 cases were confirmed for final analysis. The mean age of patients was 42 years (5 to 83 years). 50.4% of cases were men and 49.6% women. The most prevalent clinical type was the ulcerative form and the mean duration of disease was 18.4 months. Buccal mucosa was most frequently involved followed by the tongue and gingiva. A white patch, Wickham’s striae and mucosal erythema were the most prevalent clinical appearance and parakeratosis , orthokeratosis and eosinophilic band the most frequent microscopic features.

Conclusion: Based on the results of this study, the correlation of clinical and pathological findings in the proper diagnosis of oral lichen planus is emphasized.


Interobserver and intraobserver variability in the histopathologic assessment of oral lichen planus based on modified WHO criteria
Fereshteh Baghai Naini, Shiva Gandomi, Pouyan Aminishakib, Nazanin Mahdavi, Monir Moradzadeh, Mohamad Javad Kharazifard, Maedeh Ghorbanpour,
Volume 31, Issue 1 (6-2018)
Abstract
Background and Aims: In 1978 WHO (World health organization) formulated a histopathological definition for diagnosis of OLP (oral lichen planus). Previous studies showed that diagnosis of OLP with these criteria are not reproducible. In 2003 Van der Meij et al. represented new clinical and histopathologic definition for diagnosis of OLP known as modified WHO criteria. The purpose of this study was to evaluate the interobserver and intraobserver variability in the histopathological assessment of OLP based on the modified WHO criteria.
Materials and Methods: Fifty five microscopic slides which OLP and OLL (Oral Lichenoid Lesion) were recognized in their clinical differential diagnosis were given to 6 pathologists in two phases with 3 months interval. Each reviewing pathologist was asked to apply the modified WHO definition of OLP and to categorize each case as either OLP, or compatible with OLP. Then, the interobserver and intraobserver variability were assessed by calculation of repeatability coefficient and Kappa statistics.
Results: The results of this study demonstrated that interobserver variability based on modified WHO criteria was 0.77 (strong), while the intraobserver variability varied from 0.58 (moderate) to 0.82 (strong).
Conclusion: In the present study, the interobserver and intraobserver variability in the histopathologic assessment of OLP based on modified WHO criteria was stronger than previous studies which assessed WHO criteria. However, in order to propose the replacement of WHO criteria with modified WHO criteria, further studies with more cases and comparing the two methods is required.

The comparison between low level infra-red laser and triamcinolone acetonide mouth rinse in treatment of oral lichen planus lesions
Mandana Khatibi, Arash Azizi, Abbas Kamali, Soheila Mohammadian,
Volume 31, Issue 2 (9-2018)
Abstract
Background and Aims:The erosive and ulcerative forms of Oral lichen planus causes pain and irritation, affects the nutrition and biological quality of the patient. Considering the high prevalence of the disease, the complications of conventional treatments and the resistance to classical drug therapy, the aim of this study was to compare the effect of infrared low level laser and triamcinolone acetonide mouth rinse on treatment of oral lichen planus lesions.
Materials and Methods:In this double blind clinical trial, 24 patients were selected randomly according to the inclusion and exclusion criteria and divided into two groups of 12. Before and after the study, pain and burning sensation index (VAS), apparent shape and score of the lesion and size of the lesion were recorded in the patients. We treated the first group with low level infrared laser (810 nm) twice a week with 0.5-2 j/cm2 energy density and 300 mW/cm2 power density up to a maximum of 10 sessions. For the second group, we prescribed a mouth rinse of triamcinolone acetonide 0.2% four times a day with antifungal drugs for a month. Then, the study`s criteria were recorded after the completion of treatment. All data were statistically analyzed using the repeated measure ANOVA test to compare the quantitative changes over time, The Mann-Whitney U test was used to compare the rank variables between two groups at any time and Friedman test for each group between different times.
Results: There was no significant difference between the groups in terms of severity of pain (P=0.255), score and size (P=0.186), and appearance (P=0.178) of the lesions among two groups. Although the two groups showed a significant decrease in all three indicators.
Conclusion:Considering that in both groups, all three indices were improved and these improvements were similar, it seems that laser therapy can be effective. It could be used as a therapeutic alternative in treating patients with OLP (Oral Lichen Planus) especially in cases with contraindication in corticosteroid administration or lack of appropriate therapeutic response or when there is resistance to treatment.

Effectiveness of plaque control on improving gingival manifestation of oral Lichen planus: A review of literature
Yalda Elham, Neda Moslemi, Hoda Barati,
Volume 31, Issue 4 (1-2019)
Abstract
Background and Aims: Lichen planus is a chronic inflammatory mucocutaneous disease with unknown etiology. One of the most common manifestations of patients with oral lichen planus is gingival involvement in the form of generalized erythematous areas. The aim of this study was to review the articles evaluating the role of plaque control on the gingival manifestations of oral lichen planus.
Materials and Methods: Motor searches of Ovid Medline and EM base databases, PubMed, Google Scholar, and Science Direct were searched for article published between January 1990 and December 2017 using of relevant key words. After reviewing the abstracts of articles, 20 full articles were selected and among them, 7 relevant articles were reviewed in this study.
Conclusion: From the literature, it was concluded that effective plaque control is the main part of lesions treatment and improvement of symptoms and gingival manifestations of oral Lichen planus.

Comparison of vitamin D3 serum levels in patients with oral lichen planus and healthy individuals
Seyed Javad Kia, Mohammad Samami, Negin Sheykhlari, Fereshteh Najar Karimi,
Volume 36, Issue 0 (5-2023)
Abstract
Background and Aims: Considering the regulatory role of vitamin D3 in the immune system, this vitamin may be able to prevent autoimmune diseases by modulating the immune system, so this study was conducted with the aim of comparison of the serum level of vitamin D3 in patients with oral lichen planus and healthy persons.
Materials and Methods: In this case-control study, the serum vitamin D3 level of 80 people, including 40 patients referred to Guilan dental school who were suffering from oral lichen planus and 40 healthy individuals referred to the laboratory for routine check-up, after matching for age and gender, was investigated. Data based on the type of variable were analyzed using independent t-tests, Mann-Whitney, Chi-square test, and Fisher's exact test using SPSS26 software at a significance level of 0.05.
Results: In this study, 80 person participated, including 29 women (72.5%) and 11 men (27.5%) in each of two groups of patients with an average age of 52.17 ± 12.12 years and healthy people with an average age of 52.10 ± 12.23 years. The average serum level of vitamin D3 in the control group was significantly higher than the case group (P=0.006). There was no statistically significant relationship between the vitamin D3 serum level and different types of oral lichen planus, gender, duration of disease, and age.
Conclusion: Considering the significant lower mean serum level of vitamin D3 in people with oral lichen planus; vitamin D3 may be effective as a supplement in the healing process of patients' lesions.

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