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Effect of adding Matrix Metallo proteinase inhibitors on the degree of conversion of monomers to polymer an experimental bonding agent
M. Ghavam, M. Atai, M. Imani, M. Reshad,
Volume 22, Issue 2 (11-2009)
Abstract

Background and Aim: In spite of the achievements in the field of dental adhesives, we are facing challenges with dentine bonding resistance, strength and stability. According to recent studies the role of MMP inhibitors in association with bonding,s persistence and leakage reduction and restoration,s persistence is important. The aim of this study was to investigate the effect of doxycycline as a MMP inhibitor on the degree of conversion (DC) of an experimental dental adhesive.

Materials and Methods: In this experimental study, a new dental adhesive blend was prepared by mixing doxycycline monohydrate (in concentrations of 0.0, 0.25, 0.5, and 1 wt.%) with monomers. The monomers were composed of 12% Bis-GMA and 10% TMPTMA, 28% HEMA, and 50% Ethanol by weight for all groups. Comphorquinone and amines were chosen as photo initiator system. Degree of conversion of all adhesives was measured using FTIR spectroscopy. The results were analyzed using one-way ANOVA and Tukey post hoc tests.

Results: The results showed that addition of 0.25, 0.5, and 1 weight percent doxycycline did not significantly reduce the DC of the adhesives compared to 0.0% control group (p>0.05%).

Conclusion: According to the results of this study, adding doxycycline to the adhesives did not adversely affect the DC.


Production of an experimental bonding agent containing doxycyicline as matrix metalloproteinase inhibitor, and its release rate
M. Ghavam, S. Arami, M. Reshad, M. Imani, M. Ataei, M. Mirzaei, E. Yasini, M. Hasani Tabatabaei, A. Pahlavan, H. Kermanshah ,
Volume 22, Issue 4 (1-2010)
Abstract

Background and Aims: In spite of the advances achieved in the field of dentin adhesives, the longevity of bond to dentin is still a challenge. According to recent studies, Matrix Metaloproteinase (MMP) inhibitors can increase clinical longevity of bonding and decrease leakage. The aim of this study was to evaluate the amount and pattern of doxycycline release from an experimental dentin adhesive containing this MMP inhibitor.

Materials and Methods: In this experimental study, specimens containing 0.25 and 0.5 loading percent of doxycycline in an experimental monomer were prepared in cylindrical moulds of 12 mm diameter and 2 mm thickness. The adhesive monomer was composed of 12 wt% Bis-GMA, 10 wt% TMPTMA, 28 wt% HEMA and 50 wt% ethanol. Camphorquinone and amine were used as initiators.

Results: Addition of 0.25 and 0.5 w% doxycycline showed linear release in both groups. Increasing the loading percent of doxycycline caused more release. The release continued during the test period.

Conclusion: Doxycycline release was observed from the experimental adhesive. Further studies in this field will help in preparing adhesive systems with more clinical longevity.


Effect of different synthetic matrix metalloproteinase inhibitors on composite-dentin microtensile bond strength durability
Abdolrahim Davari, Alireza Daneshkazemi, Farnaz Frahat, Fatemeh Kohestani,
Volume 32, Issue 1 (7-2019)
Abstract
Background and Aims: Despite patient’s demand increased for tooth color restorations, the stable bond between dentin and composite is a challenge in dentistry. Dentin protease activation is responsible for dentin-resin bond failure. The aim of this study was to determine the best pretreatment agent to inhibit matrix metalloproteinase and increase resin-dentin bond durability.
Materials and Methods: After collecting 24 intact third molars, the dentin surfaces were exposed immediately under DEJ. After acid etching of dentin rewetting was done with CHX 2%, EDC 0.3 M for 60 and water (control group). Then the adhesive (Single bond, 3M ESPE, USA) and composite (Filtek Z250 XT, 3M ESPE, USA) were applied. 48 sectioned dentinal specimens were prepared. The specimens were divided into 3 groups. Each group was divided into 2 sub groups (n=8). In half of each group, the micro tensile bond strength test was done immediately and another part half 6 months. Then, the specimens were evaluated by stereomicroscope and SEM. Statistical analysis was performed using SPSS23 software, two-way ANOVA and multiple Tukey and T-test comparisons. P<0.05 was considered as a significant level.
Results: There were not significant differences between immediate micro tensile bond strength of CHX, EDC and control groups (P=0.97). However, there was significant differences between CHX, EDC compared with the control group (P≤0.0001). Comparison between the immediate and 6-month bond strengths in each group, only in EDC group, there was no significant after 6 months’ difference (P=0.64).
Conclusion: EDC and CHX t did not have any effect on the immediate microtensile bond strength. After 6 months, EDC prevented bond strength deterioration, but the bond strength was decreased after CHX usage.

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