Showing 11 results for Mouth
J. Mahmoodian , A. Kowsari , B. Esmaeili ,
Volume 14, Issue 4 (1-2002)
Abstract
The goal of this investigation is to compare the extent of fluoride uptake by sound enamel following application of two commercial mouthrinses containing sodium fluoride (0.2%) and a topical gel containing APF (1.23%) produced in Iran with those of foreign standardized ones. Sixty extracted premolars were used. Each tooth was divided into two lingual and buccal halves, one half as control, the other one as experimental. Enamel biopsy technique (two- step acid etching) was used to determine the concentration of fluoride and calcium in each sample. For data comparison and fluoride uptake estimation, the depths of layers with the use of linear regression analysis were standardized to 25 and 50um. The analysis showed that in Iranian mouthrinse no. 1, there is linear correlation between fluoride concentration and enamel depth, in both control and experimental group at the first and second layers, while, in other groups, this correlation was observed just at the first layer (superficial enamel layer). The greatest fluoride uptake was seen at Iranian mouthrinse no.2 and the least was seen at foreign mouthrinse no. 3. From among two APF gels, the greatest uptake was observed at gel no. 1 (Iranian). The results showed that all three Iranian products increase fluoride content of enamel, moreover the level of fluoride uptake, while applying Iranian products, in comparison with foreign ones, shows considerable increase.
Z. Ataei , H. Abdollahi , M. Salarzadeh ,
Volume 18, Issue 4 (1-2006)
Abstract
Background and Aim: Chlorhexidine is a mouthwash with known antibacterial effect but its antifungal effect is not clear. The aim of this study was to compare the antimicrobial effects of nystatin and chlorhexidine mouthwashes (one Iranian product and the other, commercial) on Candida albicans under in vitro condition. Materials and Methods: In this experimental study, the strains of Candida albicans used consisted of one standard strain (PTCC 5027) and ten local isolates. The latter were obtained from patients referred to different dental clinics in Kerman city. The specimens were taken from the gum and palate area by sterile swabs and dipped into Stewards transport medium, transferred to the laboratory within one hour, and cultured on Sabauraud dextrose Agar. Colonies showing the characteristic appearance of Candida were further cultured and routine differential tests including germ tube formation were performed to confirm the diagnosis of
C.albicans. These were used to prepare a microbial cell suspension of 0.5 Mc Farland concentration. Each cell suspension was inoculated over duplicate plates of SDA and 4 wells of 5 mm diameter were made using sterile cork borers. Each previously coded mouthwash was placed in corresponding well and incubated for 24-48 hours and the diameter of inhibition zone was measured with ruler. The minimum inhibitory concentration (MIC) of each mouthwash for each isolate of Candida albicans was determined using dilution tube technique. Data were analyzed by SPSS package using proper statistical tests with P<0.05 as the limit of significance.
Results: There was a significant difference between the antimicrobial effects of the four tested mouthwashes. The results indicated that Iranian nystatin mouthwash had the greatest effect and the average inhibition zone from the highest to the lowest was associated with Iranian nystatin, foreign nystatin, Iranian chlorhexidine and foreign chlorhexidine respectively. The MIC determination revealed that generally nystatin was more effective than chlorhexidine. No statistical difference was seen between the Iranian and foreign samples.
Conclusions: Despite the antifungal effects of chlorhexidine, more investigations on different strains of C.albicans is required before recommending its cilinical application.
M. Saghazadeh , Ao. Navidi ,
Volume 19, Issue 4 (1-2007)
Abstract
Background and Aim: Although toothbrushing is still the most effective method in plaque reduction, it is insufficient for total plaque removal. Considering this limitation, it is suggested that toothbrushing could be aided by chemical methods. For this purpose, it is advised to use some kind of mouthrinses before toothbrushing to increase the rate of microbial plaque removal. Several prebrushing mouthrinses are available in the market and comparing their efficiency is valuable for dentists. The aim of this study was to investigate and compare the effect of two prebrushing mouthrinses, Plax and Irsha, on dental plaque reduction.
Materials and Methods: This clinical trial was carried out as an interventional and triple blind protocol, using completely random block design. For this purpose, questionnaire and initial examination chart was filled for 50 healthy volunteers between the age of 18 and 40 years and finally 30 individuals were selected based on the inclusion/exclusion criteria. If scaling and polishing was necessary, it was performed at least 2 weeks before starting the main program. Then, each volunteer participated in a 4 steps program, including one step toothbrushing without use of mouthrinse and three steps toothbrushing after use of one of the mouthrinses (Plax, Irsha, Placebo). Data were analyzed by SPSS software using factorial analysis, ANOVA and Tukey’s multiple comparison tests with p<0.05 as the limit of significance.
Results: Toothbrushing without use of mouthrinse decreased the amount of plaque, significantly (P<0.0001). Use of mouthrinse without toothbrushing decreased the amount of plaque significantly (P<0.0001). The amount of plaque reduction after use of various mouthrinses (Plax, Irsha, Placebo) showed no statistical differences (P=0.761). Use of the mouthrinses before toothbrushing, had no statistically significant effect on the final results after toothbrushing (P=0.331).
Conclusion: According to the findings of the present study, although using mouthrinses decrease the amount of dental plaque significantly, but the prebrushing mouthrinse didn't show statistically significant effect on final result after toothbrushing.
P. Deyhimi, M. Nikbakht Dastjerdi, F. Morsali, Sh. Kazemi,
Volume 21, Issue 1 (10-2008)
Abstract
Background and Aim: A single nucleotide polymorphism at codon 72 of the p53 gene alters the p53 protein structure and affects its activity. This polymorphism depends on geographic regions and race. Also its association with some cancers has been reported. The aim of this study was to investigate this polymorphism in well differentiated oral SCC and normal population in the city of Isfahan.
Materials and Methods: In this case-control study, 20 paraffin blocks of non metastatic and well differentiated oral SCC were selected from the archive of oral pathology department of dental school between 2001 and 2005. 20 whole blood samples from normal people were considered as control group. After DNA extraction, p53 codon 72 polymorphism was determined by polymerase chain reaction (PCR) technique using specific primers of Arg and Pro and agarose gel electrophoresis. Data were analyzed by Fisher's exact test with p<0.05 as the level of significance.
Results: The prevalence of Arg/Arg , Arg/Pro and Pro/Pro genotypes in case group were 45%,45% and 10% respectively compared to 45%,50% and 5% in controls. There was no statistical significant difference in p53 codon 72 genotypes distribution between case and control groups.
Conclusion: Based on the results of this study, p53 polymorphism could not be considered as a genetic predisposing factor for oral SCC development in Isfahan.
Elham Zajkani, Habib Zeighami, Alireza Zaeefjou,
Volume 30, Issue 1 (6-2017)
Abstract
Background and Aims: Dental caries is an infectious disease transmitted by multiple factors in the mouth and one of the most common chronic diseases in the world that requires a lot of treatment expenses. The aim of this study was to evaluate the effect of fluoride 0.2% and Fuchs mouthwash (a combination of xylitol and fluoride 920 ppm) against two bacterial growths (Streptococcus mutans and Lactobacillus acidophilus).
Materials and Methods: In this in vitro study, first the well diffusion method and then MIC method (minimum inhibitory concentration) were used. Data were analyzed with Excell (2016).
Results: The results of the MIC method showed inhibitory effect of both mouthwashes in pure concentration (128 μg/ml). However, fluoride was effective in concentration higher than 32 μg/ml for Streptococcus mutans and higher than 2 μg/ml for lactobacillus acidophilus. Fuchs was effective for both bacteria at concentration higher than 64 μg/ml and in lower concentration it was ineffective. The results of the well diffusion test showed the inhibition of fluoride mouthwash in pure concentration on the Streptococcus mutans was (17 mm) and on the lactobacillus acidophilus 24 mm was obtained. In Fuchs mouthwash was zero and it represented effectiveness of fluoride on bacteria and ineffectiveness of Fuchs.
Conclusion: The fluoride mouthrinse in different concentrations, because of having a good inhibitory effect in both methods on Streptococcus mutans and Lactobacillus acidophilus was more effective compared with that of Fuchs mouthrinse.
Ladan Ranjbar Omrani, Masumeh Hasani Tabatabaei, Soma Faridi, Elham Ahmad,
Volume 30, Issue 3 (10-2017)
Abstract
Background and Aims: The aim of this study was to evaluate the effects of two fluoride containing mouth rinses on the color stability of two different resin composites.
Materials and Methods: 27 specimens (2×4×5 mm) were prepared from each of the following materials: a micro filled composite (Gradia, GC) and nanohybrid (Grandio). The specimens were polished by Soflex fine and superfine disks and then incubated in artificial saliva at 37°C for 24 h. The baseline color values (L, a, b) of each specimen were measured using an Easyshade spectrophotometer according to the CIELab color scale. The specimens were immersed in 20 mL of each mouth rinse and stored in an incubator at 37°C for 12 h. After incubation, the color values of all specimens were measured again, and the color change value (ΔE) was calculated. Data were analyzed by a 2-way analysis of variance at a significance level of 0.05.
Results: None of the mouth rinses created clinical significant color changes in the samples. There was no statistically significant difference among color susceptibility between resin composites (P=0.330). The interaction between the effect of mouth rinses and type of restorative materials was not statistically significant (P>0.05).
Conclusion: Accordance to the results of this study, the fluoride containing mouth rinses does not create color change in resin composites.
Mandana Khatibi, Arash Azizi, Abbas Kamali, Soheila Mohammadian,
Volume 31, Issue 2 (9-2018)
Abstract
Background and Aims:The erosive and ulcerative forms of Oral lichen planus causes pain and irritation, affects the nutrition and biological quality of the patient. Considering the high prevalence of the disease, the complications of conventional treatments and the resistance to classical drug therapy, the aim of this study was to compare the effect of infrared low level laser and triamcinolone acetonide mouth rinse on treatment of oral lichen planus lesions.
Materials and Methods:In this double blind clinical trial, 24 patients were selected randomly according to the inclusion and exclusion criteria and divided into two groups of 12. Before and after the study, pain and burning sensation index (VAS), apparent shape and score of the lesion and size of the lesion were recorded in the patients. We treated the first group with low level infrared laser (810 nm) twice a week with 0.5-2 j/cm2 energy density and 300 mW/cm2 power density up to a maximum of 10 sessions. For the second group, we prescribed a mouth rinse of triamcinolone acetonide 0.2% four times a day with antifungal drugs for a month. Then, the study`s criteria were recorded after the completion of treatment. All data were statistically analyzed using the repeated measure ANOVA test to compare the quantitative changes over time, The Mann-Whitney U test was used to compare the rank variables between two groups at any time and Friedman test for each group between different times.
Results: There was no significant difference between the groups in terms of severity of pain (P=0.255), score and size (P=0.186), and appearance (P=0.178) of the lesions among two groups. Although the two groups showed a significant decrease in all three indicators.
Conclusion:Considering that in both groups, all three indices were improved and these improvements were similar, it seems that laser therapy can be effective. It could be used as a therapeutic alternative in treating patients with OLP (Oral Lichen Planus) especially in cases with contraindication in corticosteroid administration or lack of appropriate therapeutic response or when there is resistance to treatment.
Seyyed Amirhossein Mirhashemi, Sahar Jahangiri, Mina Mahdavi Moghaddam, Rashin Bahrami,
Volume 32, Issue 4 (1-2020)
Abstract
Background and Aims: All metal components of orthodontic appliances are somewhat corroded in the oral environment due to some changes in chemical, mechanical, thermal, microbiological and enzymatic factors which facilitates ion release. Ionic release can result in a discoloration of the surrounding soft tissue or allergic reactions in sensitive patients or even local pain in the area. In general, ions can cause toxic and biological side effects if their values reach the threshold, so the release of ions from the metal components of orthodontic appliances is important to us. The aim of this review article to determine the rate of orthodontic appliances ion release in different solutions.
Materials and Methods: A review of the literature was carried out in Pubmed, Google Scholare and Web of science database using selected key words (Saliva/ Titanium/Normal Saline/ Ion release Orthodontic appliance/Mouth wash/ Nickel/ Chromium). These searches were limited to the articles published from 2005 to 2018. According to the inclusion and exclusion criteria, 25 articles were obtained.
Results: Because of conflicts in the reported results, it was necessary to synchronize the measurement methods and also to use artificial saliva medium with normal pH as a control to achieve better systematic comparison.
Conclusion: There was significant differences in the ion release between mouthwashes. In all studies, the effect of pH and acidity has been shown to increase the release of these ions. In addition, stainless steel (SS) instruments had the least biocompatibility among all types of alloys evaluated.
Pegah Palizban, Neda Kargahi, Forouz Keshani,
Volume 33, Issue 2 (8-2020)
Abstract
Background and Aims: Pre-cancerous lesions of the oral mucosa as important malformation need acceptable knowledge of dentists. The purpose of this study was to determine the knowledge of Isfahan city general dentists about pre-cancerous lesions of oral cavity.
Materials and Methods: This descriptive cross-sectional study based on validated questioner form was performed in 115 general dentists in Isfahan City in 2019, associated with sex and year of graduation from general dentistry course. The mean score was in the range from 0 to14. Data were recorded in Microsoft Excel and then analyzed by SPSS. In order to compare quantitative variables, independent T–Test, One-Way ANOVA and Mann-Whitney was used. P≤0.05 was considered as significant.
Results: The mean age in the participants of: lower than 5 years, between 5-10 years, and more than 10 years of graduation were 28.6±4.9, 30.6±4.0 and 47.9±10 years old, respectively. In total population, the mean score of knowledge was 5.97±2.79. There was not any significant difference between the mean score of knowledge in women when compared to men (5.96±2.99 versus 5.98±2.6; P=0.58). The mean knowledge score in the participants of: lower than 5 years, between 5-10 years, and more than 10 years, of graduation were as follow: 7.8±2.2 versus 5.8±2.9 versus 4.4±2.1, correspondingly (P≤0.05).
Conclusion: For the early diagnosis of pre-cancerous lesions of the oral cavity, retraining program based on oral cavity pathology courses is recommended for the dentists in Isfahan city.
Fereshteh Naser Alavi, Ashkan Salari, Seyedeh-Maryam Tavangar, Reza Tayefeh Davalloo, Farideh Darabi, Zahra Farzi,
Volume 36, Issue 0 (5-2023)
Abstract
Background and Aims: The white color of teeth is one of the most essential factors in smile esthetics. Therefore, various whitening agents such as bleaching mouthwashes have been produced in response to the people’s high demand for having whiter teeth. The present study evaluated the efficacy of three whitening mouthwash products on tooth enamel whiteness.
Materials and Methods: In the present in vitro study, 32 bovine incisors were assigned to four groups in terms of the mouthwash used (n=8): control (C); Xenon Smart White (ZSW), containing pyrophosphate and triphosphate; Signal White Now (SWN), containing Blue Covarine; and Pasta Del Capitano whitening mouthrinse (PCW), containing Plasdone. Colorimetry was carried out using a spectrophotometer at the baseline and 2, 4, 8, and 12 weeks after treatment with mouthwashes. Data were analyzed using CIELab parameters with ANOVA, RM two-way ANOVA, and post hoc Tukey tests (α=0.05).
Results: The results showed that the whiteness created by the SWN mouthwash was clinically visible (ΔE>3.3). However, the functions of all the mouthwashes were statistically similar with no significant differences from the control group (P>0.05).
Conclusion: Although, Blue Covarine-containing mouthwash was somewhat effective in whitening of tooth enamel, none of the mouthwashes had significant efficacy compared to distilled water.
Seyed Javad Kia, Mohammad Samami, Negin Sheykhlari, Fereshteh Najar Karimi,
Volume 36, Issue 0 (5-2023)
Abstract
Background and Aims: Considering the regulatory role of vitamin D3 in the immune system, this vitamin may be able to prevent autoimmune diseases by modulating the immune system, so this study was conducted with the aim of comparison of the serum level of vitamin D3 in patients with oral lichen planus and healthy persons.
Materials and Methods: In this case-control study, the serum vitamin D3 level of 80 people, including 40 patients referred to Guilan dental school who were suffering from oral lichen planus and 40 healthy individuals referred to the laboratory for routine check-up, after matching for age and gender, was investigated. Data based on the type of variable were analyzed using independent t-tests, Mann-Whitney, Chi-square test, and Fisher's exact test using SPSS26 software at a significance level of 0.05.
Results: In this study, 80 person participated, including 29 women (72.5%) and 11 men (27.5%) in each of two groups of patients with an average age of 52.17 ± 12.12 years and healthy people with an average age of 52.10 ± 12.23 years. The average serum level of vitamin D3 in the control group was significantly higher than the case group (P=0.006). There was no statistically significant relationship between the vitamin D3 serum level and different types of oral lichen planus, gender, duration of disease, and age.
Conclusion: Considering the significant lower mean serum level of vitamin D3 in people with oral lichen planus; vitamin D3 may be effective as a supplement in the healing process of patients' lesions.
