Poly (lactic-co-glycolic acid) is a biodegradable polymer which has used in a different fields of medical applications. As PLGA is approved by FDA(food and drug administration) the range of this usage is increasing in comparison to the past. Particularly, PLGA are also developed for the dental field in the form of scaffolds, films, membranes, microparticles, or nanoparticles. PLGA scaffolds have been used to regenerate damaged tissues together with stem cell-based therapy. There is solid evidence thatthe development of PLGA microparticles and nanoparticles may be beneficial to a wide range of dental fields such as endodontic therapy, dental caries, dental surgery, dental implants, or periodontology. The aim of the current paper was to review the recent advances in PLGA materials and their potential uses in Dentistry via exploring related literature during 2004 till 2016 in Science Direct and PubMed.