Journal of Dental Medicine

Background and Aims: Despite the significant improvement in dentistry, pain after endodontic therapy is still of concern for patients. Non-steroidal anti-inflammatory drugs are the most commonly prescribed oral analgesics used for dental pain relief after root canal treatment. The purpose of this study was to compare the effectiveness of Ibuprofen versus slow-released Diclofenac Sodium in controlling pain following root canal treatment.

Materials and Methods: In this randomized clinical trial, mandibular molars with irreversible pulpitis in 90 patients were selected. The patients were divided into three groups (Ibuprofen, slow-released Diclofenac Sodium and placebo). After examination patients filled in the consent form. Then they received one of the mentioned drugs. After inferior alveolar nerve block, access cavity was prepared and the root canals were prepared using passive step back method. The canals were dried and temporary filling material was placed. Then the pain evaluation form (visual analog scale) was explained and delivered to the patients. Data were analyzed using Repeated Measurement ANOVA, Kruskal-wallis and Man-Whitney U tests.

Results: The mean pain intensity in slow-released Diclofenac Sodium group was 0.87 0.95, 1.17 1.10 for Ibuprofen group, and 2.14  1.70 for placebo group. The differences between groups were statistically significant (P<0.001). The effect of Ibuprofen in controlling post endodontic pain in the first 2 hours was more than slow-released Diclofenac Sodium (P=0.01), but in 10, 18, and 36 hours after treatment, slow-released Diclofenac Sodium was more effective than Ibuprofen (P<0.001).

Conclusion: Premedication with single dose of slow-released Diclofenac Sodium can control post endodontic pain for a longer period of time compared with Ibuprofen.

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  Background and Aims: Postoperativee endodontic pain is an outstanding problem for dental patients. Therefore, a successful management of endodontic pain has become as one of the main dental objectives. The aim of the present study was to compare the postoperative endodontic pain in patients under general anesthesia versus local anesthesia.

  Materials and Methods: For conducting this clinical trial study, 50 patients having mandibular molars candidate for root canal therapy were selected. Twenty-five patients treated under general anesthesia because of their fear, anxiety or gag reflex. Other 25 patients treated under local anesthesia. All teeth were prepared using engine-driven rotary system in a crown-down technique and filled using lateral condensation technique. Heft- parker visual analog scale was used to measure the degree of pain at 6, 12, 24, and 48 hours after the treatment. Mann-Whitney, Chi-square, and T-tests were used to compare the intensity of postoperative pain between the groups.

  Results: The mean intensity of postoperative pain in local and general anesthesia groups at 6, 12 and 24 hours had statistically significant difference (P<0.05).

  Conclusion: Postoperative pain in patients who treated under general anesthesia was significantly less than the patients who treated under local anesthesia.

Background and Aims: Management of pain and inflammation after third molar surgery is an important challenge of this treatment. Various medications have been proposed for pain control after surgery. Comparing the effectiveness of various drugs used in this field can improve dentists' clinical decisions. The aim of this study was to compare the effect of Ketorolac and Gelofen on pain relief in patients undergoing third molar surgery.
Materials and Methods: This randomized single-blinded clinical trial was performed on 140 patients who were divided into two groups of 70 after receiving the ethical code. The first group was prescribed 400 mg Gelofen capsule for 1 week, while the second group was prescribed 30 mg ketorolac ampule for 1 week. Then, using the visual analog scale (VAS), the patient’s pain was recorded 48 hours, 1 week, and 2 weeks after surgery. Data analysis was carried out using SPSS20 software by descriptive analysis of the results. Ki-square, T-test, and variance analysis were also used for analysis of variables.
Results: The pain level in the ketorolac group after 48 hours, 1 week, and 2 weeks following surgery was significantly less than Gelofen group (P<0.01). Ketorolac effect on pain was irrelevant to the gender, age, and type of tooth variables.
Conclusion: From the results, it was concluded that Ketorolac had greater effect on pain relief after third molar surgery than Gelofen.