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Ak. Khoshkhoonejad , Sh. Mohseni Salehi Monfared , Hr. Hassanjani Roshan ,
Volume 17, Issue 1 (4-2004)
Abstract

Statement of Problem: Chronic periodontitis is one of the most prevalent periodontal diseases in the world which may be treated through surgical or non-surgical approaches.
Purpose: The aim of this study was to compare the efficacy of Doxycycline and placebo following SRP in non-surgical treatment of chronic periodontitis.
Materials and Methods: This double blind interventional study was conducted on patients attended to the periodontology department of Tehran faculty of dentistry from 2002 to 2003. After SRP, 22 cases and 23 controls were received Doxycycline and placebo, 20 mg twice a day for 3 months, respectively. Bleeding on probing (BOP), pocket depth (PD)<6mm and PD>7mm, and also clinical attachment level (CAL)<6mm and CAL>7mm in cases and controls after 3 and 6 months were compared by student t-test.Results: BOP after 3 and 6 months in Doxycycline recipients following SRP were significantly lower than in placebo recipients (P^0.007 and P=0.045 respectively). PD<6mm, PD>7mm, CAL<6mm and CAL>7mm in 3 and 6 months after SRP in cases were much lower than controls.
Conclusion: This study showed that the administration of Doxycycline for 3 months after SRP resulted in improvement of clinical indices as compared with SRP alone. Therefore, Doxycycline administration is recommended for chronic periodontitis treatment after SRP.
Z. Kadkhoda , S. Sanjabi ,
Volume 17, Issue 3 (8-2004)
Abstract

Statement of Problem: Elimination of porphyromonas gingivalis (p.g) from subgingival area in order to successfully treatment out comes in patients with Aggressive periodntitis AP is necessary.

Purpose: The aim of this study was the evaluation of non-surgical treatment efficacy in reduction of bacterial population in deep pockets.

Materials and Methods: In this randomized clinical trial study we evaluated the result of non- surgical therapy on reduction of p.g count from deep pockets of patients with aggressive periodontitis that had at least one (p.g plus) deep pocket (>5mm) in each quadrant. At first stage of non-surgical treatment intra pocket irrigation with chlorhexidin was done after scaling and root planning for all patients. In second stage (one week later) antibiotics including amoxicillin- metronidazol prescribed for ten days. At base line, one, six and twelve weeks after beginning of therapy, microbial samples, plaque index, bleeding on probing index and probing pocket index were recorded.

Result: There was statistically important difference between one and six weeks after treatment with base line in colony count of p.g and all of clinical indices. But in 12 weeks after therapy just, PI and PPD had statistical difference with base line. In this stage, colony count and BOP was reduced but this reduction had not statistically important difference with base line.

Conclusion: Thus in present study our non- surgical strategy in elimination of p.g and clinical improvement was successful in short time but three month after therapy recurrence of disease happened in some patients.



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