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Showing 3 results for Squamous Cell Carcinoma
Investigation of p53 codon72 polymorphism in oral squamous cell carcinoma (SCC) specimens and normal population by PCR
P. Deyhimi, M. Nikbakht Dastjerdi, F. Morsali, Sh. Kazemi,
Volume 21, Issue 1 (10-2008)
Abstract

Background and Aim: A single nucleotide polymorphism at codon 72 of the p53 gene alters the p53 protein structure and affects its activity. This polymorphism depends on geographic regions and race. Also its association with some cancers has been reported. The aim of this study was to investigate this polymorphism in well differentiated oral SCC and normal population in the city of Isfahan.

Materials and Methods: In this case-control study, 20 paraffin blocks of non metastatic and well differentiated oral SCC were selected from the archive of oral pathology department of dental school between 2001 and 2005. 20 whole blood samples from normal people were considered as control group. After DNA extraction, p53 codon 72 polymorphism was determined by polymerase chain reaction (PCR) technique using specific primers of Arg and Pro and agarose gel electrophoresis. Data were analyzed by Fisher's exact test with p<0.05 as the level of significance.

Results: The prevalence of Arg/Arg , Arg/Pro and Pro/Pro genotypes in case group were 45%,45% and 10% respectively compared to 45%,50% and 5% in controls. There was no statistical significant difference in p53 codon 72 genotypes distribution between case and control groups.

Conclusion: Based on the results of this study, p53 polymorphism could not be considered as a genetic predisposing factor for oral SCC development in Isfahan.


Evaluation of microvascular density by CD34 in squamous cell carcinoma of the tongue and its relationship with cervical lymph node metastasis
N. Eshghyar, P. Motahhary, S. Rahrotaban,
Volume 21, Issue 4 (1-2009)
Abstract

Background and Aim: Angiogenesis plays a central role for development and progression of malignant tumors.It is considered as an important factor for predicting of malignant tumor's behavior such as metastasis to lymph nodes and other clinicopathologic factors. However , it is still a controversial factor especially in oral squamous cell carcinoma.The aim of this study was to evaluate the correlation between angiogenesis and clinicopathologic parameters such as presence of metastatic cervical lymph node in the tongue squamous cell carcinoma.

Materials and Methods: In this cross-sectional study, 40 cases of squamous cell carcinoma of the tongue were selected from the archive of cancer institute of Tehran University of Medical Science. Sections were prepared from paraffin blocks and immunohistochemically stained with antibody against CD34. Stained vessels were counted in 4 fields ,the most vascular areas at low magnification, in each areas of intratumoral ,peritumoral and nontumoral adjacent tissue in two groups with metastatic lymphnodes (N+) and without (N-). The average counts from the four most vascular areas were recorded as the mean microvascular density (MVD). Data were analyzed by 3wayANOVA and Independent T- test with p<0.05 as the level of significance.

Results: High mean MVD-CD34 was significantly correlate with positive cervical lymph node metastasis in intra tumoral and peritumoral areas but there was no significant correlation between mean MVD-CD34 and age, gender, and differentiation of tumor.

Conclusion: Based on the results of this study, CD34 can help us to determine the presence of cervical lymph node metastasis and may also determine the outcome of a primary squamous cell carcinoma of the tongue.


Treatment and care for oral cancer patients at Shariati hospital in Tehran in 2003-2013
Katayoun Sargeran, Amir Jalal Abbasi, Faegheh Fazeli,
Volume 30, Issue 2 (8-2017)
Abstract

Background and Aims: In modern societies, the incidence of oral cancer is increasing. It may be due to the increased population, life expectancy, and exposure to risk factors. This increase can particularly be seen in women and in our own country, Iran. The aim of the present study was to explore the status of care and treatment of patients with oral cancer referring to Shariati educational hospital in Tehran, during the years 2003-2013.
Materials and Methods: The present study was a cross-sectional descriptive survey on oral cancer patients attending the Shariati hospital in Tehran during a ten-year period. Data were collected through patient records and statistically analyzed by SPSS21 software.
Results: Regression analysis was performed in 5 models, where variables such as age, gender, location of the tumor, stage and grade was entered as independent variables and delay in treatment (time interval from diagnosis to treatment) entered as the dependent variable. The analysis showed that the elapsed time from diagnosis to treatment had a positive association with age of the patients. It means that the higher the age, the more delay in treatment (P<0.05). No relationship was found between the treatment delay and gender, tumor location, grade, and stage.
Conclusion: Considering the consequences of oral cancer for patients, there was necessity to formulate plans for preventing, early detection and improving quality of life in oral cancer patients.
 

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