Showing 4 results for Ansari
M. Ansari, A. Mazloumi, M. Abbassinia, S. Farhang Dehghan, S. M. Hossieni, F. Golbabaei,
Volume 4, Issue 2 (7-2014)
Abstract
Introduction: Heat stress is considered as one of the hazardous occupational agents in hot environments. Working under heat stress condition may lead to individuals’ health problems. Several studies have been shown that stress in the working environments can elevate stress hormones such as cortisol. Since heat stress is one of the serious stresses in hot industries including melting, this study was done to investigate the effect of heat stress on the cortisol concentration of workers in one of the melting industries.
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Material and Method: In this cross-sectional study, 70 workers in two groups of case and control (35 people in case group from foundry unit and 35 people in control group from casting unit without heat stress) were investigated. First, a demographic questionnaire was complete for each subject. Then in order to evaluate the changes in cortisol level, blood samples were taken from the participants during their working hours (9:30 to 10 AM) and the obtained levels were compared with the normal level of cortisol, provided at 7 to 10 AM. In order to assess environmental condition, WBGT (Wet Bulb Globe Temperature) index was measured at three highest including feet, waist and head. Moreover, noise and lighting were measured at the workers work station. Data were analyzed using SPSS software version 16.
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Result: Regarding WBGT, it was shown that mean WBGT index were 33 C and 16.7 C in case and control groups, respectively. Additionally, cortisol concentration in case group was significantly higher than control group (P<0.001).
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Conclusion: Results of the present study indicate that physical stresses of working environment can lead to changes in physiology of human body. Thus, variations in hormone level in its consequences in hot environment should be considered in occupational hygine.
Rabee Menhaje-Bena, Mohammad Kazem Koohi, Soroush Modabberi, Mmahmood Ghazi Khansari, Shahnaz Bakand,
Volume 11, Issue 1 (3-2021)
Abstract
Introduction: Particulate matter (PM) is known as the most common cause of air pollution in the world. Activities of sand quarries are known as one of the emission sources in Tehran. This study aimed at investigating the geological and environmental factors of airborne particles in an active quarry in the west of Tehran.
Material and Methods: Three methods of dust sampling were used. totally, 32 samples were analyzed by Scanning Electron Microscope-Energy Dispersive X-ray (SEM-EDX). The data were analyzed through Principal Component Analysis (PCA), Enrichment Factor (EF) and Geo-accumulation Index (Igeo).
Results: The results showed the presence of Si, Ca, Al, Na, Fe, K, Zn, Pb, P, S, Mg, Cu, Ti, Mn, Cl and V in dust of the quarry. Also, the elements of Mn, V, Zn, Cu and Pb were shown to have moderate to extremely enrichment and contamination from anthropogenic origin. The silicon and potassium were found to have a natural source originated from igneous and alluvial rocks.
Conclusion: In this study, it was shown that fugitive dust generated from sand quarries and related activities have higher concentration of elements than those in the Earth crust due to anthropogenic activities. Further studies on transfer of fugitive dust from sand and gravel quarries to Tehran and assessment of its health impact are suggested.
Esmaeil Karami, Zahra Goodarzi, Reza Chahardoli, Mahmoud Ghazi Khansari, Mehrafarin Kiani, Seyed Jamaleddin Shahtaheri,
Volume 12, Issue 2 (6-2022)
Abstract
Introduction: Although aluminum oxide nanoparticles (Al2O3-NPs) are the most widely used nanomaterials, limited studies have been reported on their toxicology. Therefore, the present study aimed to investigate the potential toxicity of aluminum oxide (alumina) nanoparticles and the protective role of aqueous extract of wormwood plant on nanomaterial-induced disorders in the lung of rats.
Material and Methods: Here, 36 male Wistar rats were randomly divided into six groups. Next, the rats were first exposed to 200 mg/kg of the aqueous extract of wormwood plant (by gavage) for 15 days and then received a dose of 30 mg/kg of aluminum oxide nanoparticles as an intraperitoneal injection for 14 days. Furthermore, various features of clinical signs, body weight, biochemical parameters, gene expression changes, lung weight ratio, histopathological observations, and metal content in lung tissue were evaluated during the experiment. Eventually, the ANOVA (Analysis of Variance) and Tukey’s range test were employed to analyze and compare the mean of the data.
Results: The results revealed that aluminum oxide nanoparticles at a concentration of 30 mg/kg body weight led to changes in antioxidant enzyme activities, e.g., T-SOD, CAT, GPx, and TAC, lipid peroxidation, and iNOS for exposed rats. Also, the above biochemical disorders were associated with altered expression of oxidative stress-related genes (HO-1, MT-1) and histological changes in the lung tissue. On the other hand, simultaneous intake of aqueous extract of wormwood plant and aluminum oxide nanoparticles in rats significantly improved the studied parameters (p <0.05).
Conclusion: Our findings showed that the γ-Al2O3 NPs were more toxic than α-Al2O3 NPs, which can be attributed to changes related to their size and shape characteristics. Also, it was observed that the wormwood plant could play a protective role against aluminum oxide nanoparticles-induced pulmonary toxicity in rats.
Peymaneh Habibi, Seyed Nasser Ostad, Ahad Heydari, Mohammad Reza Monazzam, Abbas Rahimi Foroushani, Mahmoud Ghazi-Khansari, Farideh Golbabaei,
Volume 12, Issue 4 (12-2022)
Abstract
Introduction: Climate change and hot processes in the workplaces has led to an increase in the effects of heat stress on employed people, which has become a major concern, especially in tropical and subtropical countries. Early detection of biomarkers in induction of heat stress-related DNA damage can be used in the identification and evaluation of health and safety, including occupational health professionals, as well as to prevent serious diseases caused by heat stress in various occupations with the nature of hot processes or to help different warm seasons of the year. Therefore, this review study was conducted to identify diagnostic biomarkers heat stress induced- DNA damage in occupational exposure.
Material and Methods: Databases such as PubMed, Scopus, Google Scholar, and Web of Science were systematically searched to meet the study’s goals. Moreover, references to relevant publications were examined. Finally, suitable articles were selected and analyzed using the inclusion (studies on different occupations, different biomarkers in hot work environments, all articles published without time limit until the end of April 2022 , and English and Persian language) and exclusion criteria.
Results: The results of search in databases showed that 9234 articles were found in the initial search. After removing duplicate and unrelated articles, 2209 eligible articles were selected. Based on abstract full-text screening, 7166 studies were excluded, and based on abstract full-text screening, 21 studies were not accessible. Finally, seven articles were selected to be reviewed. The evidence showed that diagnostic biomarkers included the measurement of 8-hydroxy-2-deoxyguanosine (8-OHdG), micronuclei semen quality, heat shock proteins (HSP70), and leukocytes were extracted to heat stress induced- DNA damage in occupational exposure.
Conclusion: Based on a review of studies, biomarkers identified are suitable for heat stress induced- DNA damage as a result of occupational exposure to extremely high heat climate conditions. Understanding and identifying appropriate biomarkers in inducing DNA damage can help health and safety professionals determine the amount and magnitude of heat stress responses in occupational exposure to different temperatures and take appropriate measures and interventions to control and reduce the hazard effects of thermal stress. This study can also be considered as a preliminary study for research in the future.
