Farshad Nadri, Ali Khavanin, Farahnaz Khajehnasiri, Masoud Ghanbari Kakavandi, Zohreh Mazaheri,
Volume 9, Issue 2 (6-2019)
Abstract
Introduction: Due to the high prevalence of noise and vibration in workplaces and focused of Previous studies on the auditory and musculoskeletal effects of these two harmful factors, The aim of this study was to determine the protective effect of cinnamon extract on sex hormones levels, body weight and testis weight of adult rats exposed to noise and vibration.
Material and Methods: 64 male Wistar rats were randomly assigned to eight groups of 8 each. Group 1; treated with distilled water (Control), group 2; treated with 75 mg kg-1 cinnamon extract, group 3; exposed to noise(100 dB), 8 h/day(23:00-7:00) and group 4; exposed to noise and treated with 75 mg kg-1 cinnamon extract, group 5; exposed to vibration(1 m/s2), 8 h/day (23:00-7:00), group 6; exposed to vibration and treated with 75 mg kg-1 cinnamon extract, group 7; exposed to noise and vibration, 8 h/day (23:00-7:00) and group 8; exposed to noised and vibration and treated with 75 mg kg-1 cinnamon extarct by gavage. Fifty days later, the rats were anesthetized, blood samples to determine the amount of sex hormones were collected, and the testis was removed for weight determination. Data was analyesd by SPSS.
Results: Noise stress decreased the level of three hormones (LH, FSH and Testosterone) while vibration decreased testosterone levels merely (P<0.05).Combined exposure to noise and vibration was able to create a significant difference with control group in testosterone and LH hormone levels (P<0.05). The three factors of noise, vibration and combine of them were able to create a significant difference with control group in final body weight (P<0.05). Cinnamon extract increased the level of sex hormones compared to control group (P<0.05).
Conclusion: Cinnamon extract (due to antioxidant properties) has a protective effect on sex hormone levels in rats exposed to noise and vibration. It’s suggested further studies to determine the mechanism of cinnamon extract (in different doses) in human and animal samples.
Narges Karimtaheri, Shokoufeh Hassani, Seyed Jamaleddin Shahtaheri, Monire Khadem,
Volume 15, Issue 2 (7-2025)
Abstract
Introduction: The rising daily consumption of gasoline has increased human exposure to its vapors. Direct contact with these vapors, due to their toxic properties, can adversely affect various organs, including the heart, lungs, skin, liver, and kidneys. Cinnamon, a widely utilized medicinal plant, is rich in antioxidants and exhibits protective effects on liver and kidney health, alongside therapeutic potential for various diseases. Therefore, this animal study aimed to investigate the protective effects of cinnamon extract against oxidative stress induced by gasoline inhalation in rat kidneys.
Material and Methods: Thirty adult male Wistar rats weighing 160–180 grams were randomly divided into five groups (n=6 per group): (1) Control, (2) Cinnamon extract only, (3) Gasoline exposure only, (4) Gasoline exposure plus 100 mg/kg of cinnamon extract, and (5) Gasoline exposure plus 200 mg/kg of cinnamon extract. After four weeks of exposure, the rats were weighed and euthanized. Serum samples were collected for biochemical, serological, and enzymatic analysis, and kidney tissues were examined for histopathological changes.
Results: Gasoline exposure significantly increased kidney function markers (BUN and cystatin C) and oxidative stress markers (MDA) while reducing endogenous antioxidant activities (GSH and GPx). Histopathological analysis revealed significant kidney damage, including hemorrhage, necrosis, and tubular degeneration in the gasoline-exposed group. Cinnamon extract notably alleviated gasoline-induced kidney toxicity by reducing kidney function markers and MDA levels while enhancing endogenous antioxidant activity. Histopathological findings further confirmed the protective effects of cinnamon extract, showing reduced tissue damage in treated groups.
Conclusion: Cinnamon extract significantly reduces kidney toxicity caused by gasoline, suggesting it may protect against gasoline exposure. Its antioxidant and anti-inflammatory properties likely support this protective effect.
