Journal of Health and Safety at Work

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Introduction: Toluene is considered as a group of chemical contaminants, causing problems for people’s health. Due to the high rate of evaporation and rapid emission in the surrounding environment, it leads to the exposure of many employees and people at risk and, subsequently, its irreparable effects on their health in different jobs. Therefore, its removal is very important. In the present study, this contaminant was removed using the copper metal-organic framework (MOF) under different operating conditions. 
Material and Methods: In this study, the copper MOF was synthesized using the one-pot and in situ method. Physical and morphological properties of the adsorbent were investigated using BET, XRD, FTIR and SEM techniques. The efficiency of the adsorbent in removing toluene from the air stream under the dynamic adsorption system was investigated by examining the effect of the variables of adsorbent mass, pollutant concentration and humidity. Isotherm, thermodynamics and kinetics equations were used to evaluate the data.
Results: The results of experiments determining the properties of the metal-organic framework showed the formation of pure Cu-BDC crystals with mean and particle size distribution of 1.95 nm. The specific surface area calculated by the BET method for the mentioned sample was 686 m2 g-1 and the total volume of structural pores was 0.335 g3 cm3. The presence of micropores increased the dynamic adsorption capacity of toluene. The findings follow the Langmuir isotherm model and the Pseudo-second order kinetic model. Based on the results of thermodynamic studies, entropy change (ΔS°) and enthalpy change (ΔH°) were equal to -0.44 kJ mol-1 K-1 and -15.67 kJ mol-1, respectively. Gibbs free energy change (ΔG°) was also calculated negatively, indicating that the adsorption process was spontaneous and exothermic. The regeneration of the adsorbent was 77% after three cycles.
Conclusion: According to the results of this study, the microporous copper MOF can be used as a result of cheapness, high access, high adsorption capacity and appropriate regeneration rate in different operating conditions for adsorption of toluene.

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Introduction: Toluene, benzene, xylene, and ethylbenzene (BTEX) belong to the class of monocyclic aromatic hydrocarbons and are identified as toxic volatile compounds due to their harmful properties. The reliable biomarkers for occupational exposure to these toxic compounds are hippuric acid (HA), trans,trans-muconic acid (tt-MA), mandelic acid (MA), and methylhippuric acid (MHA), which correlate with toluene, benzene, ethylbenzene, and xylene, respectively.
Material and Methods: A novel magnetized imine-linked covalent organic framework (Fe3O4@TFPA-Bd) was synthesized, marking its inaugural use as a sorbent in microextraction by packed sorbent (MEPS). The synthesis of Fe3O4@TFPA-Bd was executed in a straightforward and efficient manner, using Fe3O4 nanoparticles as the magnetic core and benzidine (Bd) and Tris (4-formyl phenyl) amine (TFPA) as the structural building blocks. This newly produced sorbent was tested for the microextraction of hippuric acid (HA), mandelic acid (MA), trans, trans-muconic acid (tt-MA), and m-methyl hippuric acid (m-MHA) from urine samples, which were then analyzed using high-performance liquid chromatography (HPLC). In order to optimize the extraction performance, parameters like sample volume, elution volume, extraction cycles, pH, and sample solution temperature were thoroughly adjusted. The synthesized adsorbent underwent thorough characterization via scanning and transmission electron microscopy (SEM and TEM), Fourier transforms infrared spectrometer (FTIR), and X-ray diffraction (XRD).
Results: The developed method showcased promising attributes: low detection limits (0.02 µg/ml for tt-MA, S/N=3), low quantification limits (0.06 µg/ml for tt-MA, S/N=10), a solid linear range (0.5-320 µg/ml for MA, R > 0.99), and commendable intra- and inter-day precision (2.4%-4.3% and 3.1%-7.8%, respectively) for volatile organic compound (VOC) biomarkers. Furthermore, the method demonstrated recoveries in the 81-87.5% range for spiked samples, indicating its practicality and effectiveness.
Conclusion: The developed procedure was suitable for the determination of BTEX biomarkers from urine samples and can be an alternative to previous methods.

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Introduction: Due to uncertainties regarding the risks of engineered nanomaterials for human health and the environment, different organizations and researchers have developed various management frameworks and assessment tools to mitigate hazards during the procedures and applications of engineered nanomaterials. However, most of these techniques do not meet all the individual requirements. This study provides a review and introduction to the techniques developed for the management of safety, health, and environmental risks associated with engineered nanomaterials.
Material and Methods: In order to find pertinent documents on the safe handling of engineered nanomaterials, a search was conducted using the following keywords: “Engineered nanomaterials”, “Framework”, “Tool”, “Risk management”, “Occupational exposure”, “Environment”, “Risk assessment”, and “Nanotechnology”. The search was conducted on various databases, including Scopus, Web of Science, NIOSH, ECHA, and ISO. Among the search results, tools and frameworks that specifically focus on the safety, health, and environmental risk management or assessment of engineered nanomaterials were selected.
Results: Among the search results, 17 frameworks and 11 developments in the field of managing occupational, environmental, and toxicological risks associated with engineered nanomaterials were discussed. Various frameworks and tools for identifying, evaluating, and managing the potential risks of engineered nanomaterials vary in terms of their scope, goals, risk assessment approaches, and output, offering diverse applications.
Conclusion: Various tools and frameworks, each with unique properties, applications, and limitations, can assist organizations in achieving their goals related to safety, health, and environmental issues in the field of nanotechnology. Currently, there is no consensus on the optimal approach for assessing the risks of nanomaterials, underscoring the necessity for additional research, development, and collaboration in this field.
 

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Introduction: Fire safety in healthcare centers is crucial due to the limited evacuation capacity of the occupants and the necessity of not disrupting the operation in these centers. In this study, the fire risk of a public hospital was evaluated using the Fire Risk Assessment Method for Engineering (FRAME). Additionally, the factors affecting fire safety in the hospital were analyzed quantitavely, and fire control strategies were presented. 
Material and Methods: First, the fire risk assessment checklist was filled in all the hospital departments. Then, the values of the factors affecting fire safety were obtained. In the next step, the fire risk for the building, occupants and activities were estimated using Excel software-FRAME. Finally, control strategies and intervention measures were presented based on the value of these factors. 
Results: In the hospital under study, 22% of the departments posed an undesirable fire risk to the building and its property. On the other hand, 90% of the departments had risk levels that were undesirable for the occupants. The results of the initial risk (R0) showed that a balance between potential fire risk and risk acceptance can be established by implementing manual fire extinguishing systems and automatic detectors in all departments. 
Conclusion: ased on the condition of the hospital studied, a balance between potential fire risk level and risk acceptance level was not established. Therefore, there is a need for fire control measures, especially fire safety measures for the occupants. The results of this study can be useful for readers and experts in interpreting fire risk assessments and presenting detailed control measures based on the risk assessment and the value of the parameters.

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Introduction: Nanomaterials are widely applied across diverse scientific and industrial sectors; however, their emergence has introduced a new generation of occupational hazards for workers. Concurrent with discussions on the adverse effects of nanomaterials on human health, researchers have sought to develop methods for assessing occupational risks associated with these materials. Accordingly, this study aims to propose a general framework for the development of such methods.
Material and Methods: This is a critical analysis study designed to evaluate existing methods for assessing occupational risks related to nanomaterials and ultimately propose a modified framework for refining these methods. By examining current approaches and identifying their strengths and weaknesses, the authors have proposed an improved framework for occupational risk assessment of nanomaterials.
Results: The proposed framework is based on two key dimensions: “Severity/Hazard” and “Probability/Exposure.” The first dimension determines the potential risk level arising from exposure to nanomaterials, with the most critical factors being the intrinsic properties and toxicology of the nanomaterial itself, parent materials, and similar substances. The second dimension describes the likelihood and nature of exposure to nanomaterials during work activities, with the most influential factors being worker, job tasks, and workplace environment characteristics.
Conclusion: The lack of sufficient data and numerous uncertainties regarding bio-nano interactions make quantitative risk assessment (the traditional occupational health approach) difficult, less reliable, and in some cases unfeasible for nanomaterials—given current knowledge. Qualitative and semi-quantitative approaches, such as Control Banding, despite demonstrating positive aspects, have faced significant criticism. The framework-based method proposed herein appears capable of partially overcoming these challenges.

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Introduction: With the advancement of industries and increased use of metalworking fluids, controlling pollutants generated by machining operations has become increasingly challenging. This study aimed to address these challenges by designing an air filtration system designed specifically for this purpose.
Material and Methods: A local exhaust ventilation system was developed based on the VS-80-12 ACGIH standard, tailored to the working conditions and air sampling of the environment. The filtration system includes an aluminum pre-filter, an E11 class filter, and a nanofiber filter incorporating a metal-organic framework. The performance of the system was evaluated by measuring the numerical concentration of particles and the mass concentration of oil mist at both the inlet and outlet. The results were then compared to those obtained from an E1 class filter.
Results: The results obtained from XRD and FTIR analyses showed that ZIF-8 had high crystallinity and was successfully incorporated into the structure of the fibrous media filter containing metal-organic framework. The evaluation revealed that the filtration system effectively removed pollutant particles at their source. Notably, the initial efficiency for larger particles reached 100%, while the average removal efficiency for particles smaller than 2.5 microns was 99%.  
Conclusion: In conclusion, the combination of nanofiber filters with a metal-organic framework and aluminum pre-filters presents an effective solution for controlling particulate pollutants from machining operations. However, further research is necessary to comprehensively assess the system’s performance, particularly regarding dust loading capacity. Future studies should also explore the effects of various factors, such as airflow rate and the type of metalworking fluid, on the system’s efficacy.

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Introduction: Hospitals represent a critical fire safety challenge. The presence of patients with limited mobility, specialized staff, and invaluable infrastructure makes them seriously vulnerable. Further, toxic smoke inhalation, as a primary product of fire, is a leading cause of mortality. To address this concern, our study intended to conduct a comprehensive fire safety assessment of a teaching hospital in Tehran (2023-2024) by integrating risk assessment with numerical modeling.
Material and Methods: This study was conducted in a teaching hospital following three consecutive steps: risk assessment, fire scenario design, and fire and smoke modeling. First, vulnerable zones were identified using the FRAME method. Next, fire scenarios and control strategies were designed based on the identified risk factors and a review of the relevant literature. Ultimately, fire and smoke transport was modeled using the CFAST software to ascertain the performance of the proposed strategies.
Results: The risk assessment pinpointed two wards with unacceptably high occupant risk levels: the inpatient ward on the 10th floor, owing to a cluster of unsafe behaviors, and the basement warehouse, owing to improper storage and inadequate emergency exit access. Fire and smoke modeling was performed for these two zones, comparing the “current situation” against a proposed “risk control strategy.” The modeling results revealed that the control strategy positively affected key life safety indicators, significantly ameliorating the Fractional Effective Dose (FED) and Heat Release Rate (HRR).
Conclusion: According to this study, a fire risk assessment provides a clear and detailed perspective on a hospital building’s fire safety. Integrating the results of the FRAME assessment with CFAST simulations results in a comprehensive understanding of the facility’s safety status. These data can be utilized to design effective emergency plans and calculate the Required Safe Egress Time (RSET), thereby preventing life-threatening harm to occupants against toxic gases.