Mohsen Sadeghi Yarandi, Farideh Golbabaei, Ali Karimi, Ali Asghar Sajedian, Vahid Ahmadi,
Volume 10, Issue 3 (8-2020)
Abstract
Introduction: 1,3-Butadiene is a carcinogenic compound that can be emitted to the atmosphere from several sources like petrochemical industry. One way to determine the level of carcinogenic and health effects of respiratory exposure to pollutants in the workplace is to use risk assessment methods. The aim of this study was to comparative assessment of carcinogenic risk of respiratory exposure to 1,3-Butadiene in a petrochemical industry by the US Environmental Protection Agency and Singapore Health Department methods.
Material and method: This cross-sectional study was carried out in 2018 in a petrochemical industry that producing copolymer ABS (acrylonitrile, butadiene, styrene) in Iran. Occupational exposure to 1,3-Butadiene was measured according to the NIOSH 1024 method. Cancer risk assessment was done according to the United States Environmental Protection Agency (USEPA) and Singapore semi-quantitative methods.
Results: The average occupational exposure to 1,3-Butadiene during work shift among all participants was 560.82 ± 811.36 µg.m-3 (0.253 ± 0.367 ppm) and in all cases was below the occupational exposure limit. The average lifetime cancer risk in USEPA method in the present study was 2.71 × 10-3, Also in this method 82.2% of all exposed workers were in the definite carcinogenic risk level and 17.8% were in the probable carcinogenic risk level. The results of the Singapore health department method showed that 91.2% of all subjects were in the probable carcinogenic risk level and 8.8% were in the definite risk level.
Conclusion: The findings of the present study showed that the results of the Singapore semi quantitative risk assessment method are not in good agreement with the results of the quantitative risk assessment method proposed by the US Environmental Protection Agency. Therefore, given the high accuracy and thoroughness of the US Environmental Protection Agency's risk assessment methodology as a worldwide reference method for assessing the carcinogenic and health risk of exposure to chemicals, it is recommended to use this method instead of the Singapore method in future studies.
Azin Najafi, Farideh Golbabaei, Mohsen Sadeghi Yarandi, Mehdi Yaseri, Reza Jahani, Seyedeh Reyhaneh Shams, Saba Kalantary,
Volume 15, Issue 3 (10-2025)
Abstract
Introduction: Occupational exposure to volatile organic compounds (BTEX) and heavy metals in industrial settings poses significant health concerns. These substances may lead to toxic, carcinogenic, and hematobiochemical effects. This study aimed to assess the health risks associated with exposure to these pollutants in a power equipment manufacturing industry over a 10-year period and to compare the accuracy of quantitative (USEPA) and semi-quantitative (Singapore) risk assessment methods.
Material and Methods: This cross-sectional study was conducted across six occupational groups. Personal air sampling of BTEX and heavy metals was performed according to NIOSH protocols. Carcinogenic and non-carcinogenic risks were estimated using the USEPA method and the Singapore semi-quantitative approach. Additionally, hematological and biochemical indicators of exposed workers were analyzed.
Results: Nickel had the highest cancer risk, and the highest hazard quotient (HQ) values were related to xylene, benzene, and nickel. While the semi-quantitative method classified most risks as negligible to low, the USEPA method identified several cases with definite health risks. Significant effects were observed on SGOT, SGPT, fasting blood sugar, creatinine, and blood pressure among exposed groups.
Conclusion: The USEPA method demonstrated higher sensitivity and reliability in identifying occupational chemical hazards and should be prioritized in future assessments. Furthermore, the findings underscore the importance of preventive measures to reduce chronic exposure to BTEX and heavy metals in similar industrial settings.
