Background and Aim: Multiple sclerosis (MS) is a demylinating disease that due to the involvement of multiple areas in central nervous system, including sensorimotor system can impair the patients' balance. The aim of the present study was to determine the balance, extremities muscular strength and disability rate in Iranian patients with MS and to investigate the relationship between these parameters. 

Materials and Methods: Sixty eight patients with MS participated voluntarily in this study. The berg balance scale (BBS), Motricity index (MI) and self report patient determined disease steps (PDDS) were used for assessing the balance, extremities muscular strength and patients' disability rate, respectively 

Results: Fifty six of patients showed balance impairment. Balance values were significantly correlated with muscular strength of upper (p=0.011) and lower (p<0.001) extremities in patients with balance impairment. But, the relation between balance and muscular strength in patients without balance impairment was not significant (p>0.05).There was a negative correlation between balance and disability rate (p<0.001).

Conclusion: The results of this study showed that more than 50% of patients have balance impairment. Furthermore, the importance of evaluating muscle strength in order to predict the falling risk in MS patients were identified.