Volume 13, Issue 3 (Aug & Sep 2019)
payavard 2019, 13(3): 223-229 |
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Hajizadeh S, Choobineh H, Omidkhoda A, Alizadeh S, Sharifi M J, Kavosh Z. Study of Association between Factor XI Polymorphism and Recurrent Miscarriage in Iran Helal Infertility Center (Rouyesh) Patients. payavard 2019; 13 (3) :223-229
URL: http://payavard.tums.ac.ir/article-1-6815-en.html
URL: http://payavard.tums.ac.ir/article-1-6815-en.html
Sonia Hajizadeh1 
, Hamid Choobineh * 2, Azadeh Omidkhoda3 , Shaban Alizadeh4 , Mohammad Jafar Sharifi5 , Zeinab Kavosh1
, Hamid Choobineh * 2, Azadeh Omidkhoda3 , Shaban Alizadeh4 , Mohammad Jafar Sharifi5 , Zeinab Kavosh1
1- Master of Science in Hematology and Blood Banking, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran
2- Assistant Professor, Department of Laboratory science, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran ,hchobineh@tums.ac.ir
3- Assistant Professor, Department of Hematology and Blood Banking, School of Allied medical sciences, Tehran University of Medical Sciences, Tehran, Iran
4- Associate Professor, Department of Hematology and Blood Banking, School of Allied medical sciences, Tehran University of Medical Sciences, Tehran, Iran
5- Assistant Professor, Department of Immunology, Isfahan University of Medical Sciences, Isfahan, Iran
2- Assistant Professor, Department of Laboratory science, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran ,
3- Assistant Professor, Department of Hematology and Blood Banking, School of Allied medical sciences, Tehran University of Medical Sciences, Tehran, Iran
4- Associate Professor, Department of Hematology and Blood Banking, School of Allied medical sciences, Tehran University of Medical Sciences, Tehran, Iran
5- Assistant Professor, Department of Immunology, Isfahan University of Medical Sciences, Isfahan, Iran
Abstract: (2813 Views)
Background and Aim: Recurrent pregnancy loss(RPL) is known as two or three pregnancy losses before 20th week of pregnancy. RPL accounts for 5% of abortions in women and has a devastating effect on the marital status of families. One of the reasons for RPL is hemostatic complications; thus, we studied the correlation between factor XI polymorphism and RPL in patients who referred to Helal Infertility Center(Rouyesh).
Material and Methods: In this case-control study, 144 patients with a history of miscarriages(at least two) and 150 healthy female with a minimum of one successful birth and no abortion were enrolled. DNA extraction was taken from leukocytes of whole blood. To investigate the polymorphisms, polymerase chain reaction was run, and the presence of polymorphism was analyzed using RFLP method.
Results: Regarding FXI polymorphism, TT, CT, and CC genotype frequencies were 59.7%, 36.1%, and 4.2%, respectively. In healthy control group, the TT, CT, and CC frequencies were 45.3%, 49.4%, and 5.3%, respectively.
Conclusion: TT homozygote genotype could be an RPL risk factor(p<0.05); however, in its CT heterozygote form, C allele could have a protective role against RPL.
Material and Methods: In this case-control study, 144 patients with a history of miscarriages(at least two) and 150 healthy female with a minimum of one successful birth and no abortion were enrolled. DNA extraction was taken from leukocytes of whole blood. To investigate the polymorphisms, polymerase chain reaction was run, and the presence of polymorphism was analyzed using RFLP method.
Results: Regarding FXI polymorphism, TT, CT, and CC genotype frequencies were 59.7%, 36.1%, and 4.2%, respectively. In healthy control group, the TT, CT, and CC frequencies were 45.3%, 49.4%, and 5.3%, respectively.
Conclusion: TT homozygote genotype could be an RPL risk factor(p<0.05); however, in its CT heterozygote form, C allele could have a protective role against RPL.
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