Showing 15 results for Amiri
R Gholamnejad, Mr Khoramizadeh, A Razavi, A Salehinodeh, Mm Amiri, V Molakazemiha, Sa Mirshafyei,
Volume 2, Issue 4 (29 2009)
Abstract
Background And Aim : Nowadays, many inflammatory diseases such as rheumatoid arthritis (RA) and Multiple sclerosis (MS) and many other autoimmune inflammatory diseases has involved the people of different communities and cure for them so far has not been provided. Many waste irreparable these diseases caused by overexertion and chronic inflammatory cells and effects of destructive enzymes. Proteolysis like matrix Mtaloproteinazes (MMPs). Hence in this study was discussed effect of drug 4 - amino pyridine (4-AP) to Progress of inflammation in a experimental model of inflammatory response.
Materials and Methods: In this study were used, 48 Out bred rat race, all female Sprague Dawely about 200-150 gr Weight and ages 6 to 8 weeks to induce inflammatory response experiment By bovine Serum albumin (BSA) + adjuvant complete Freund (CFA). Rats were in six groups of 8 each, including: Normal group, patient group, groups of Treatment-1,Treatment-2 , Prevention-1 and Prevention-2. drug 4-AP at different concentrations (400 and 800 micrograms) to groups of Treatment-1, 2 and Prevention-1, 2 rate (0 / 1 microliter) were injected and 48 to 72 hours after injection dosage reminder (only BSA) studied and were compared severity of inflammation.
Results: 48 Rats that were studied, eight rats (66/16%), no inflammatory signs, histopathology and production of antibody anti-BSA did not show and this same group were normal. 8 rats (66/16%) clear signs of severe inflammation showed that were our patient group.32 rats (66/66%), showed less severe signs of inflammation than patients that were the same groups of Treatment-1, 2 and Prevention-1, 2 that they had been received different concentrations of 4-AP.
Discussion and Conclusion: The difference in the severity of inflammation and diffuse infiltration of inflammatory cells in Evaluation clinical, radiology, histopathology and rate of antibody anti- BSA shows that the drug 4-AP reduces the severity of inflammation in the Groups receiving medication than normal and the patient group (p <0.05). Although statistical analysis showed 4-AP Has no effect on production rate of MMPs. The groups of rats had received high concentration the drug (Prevention2 and Treatment2) than groups that low concentration of the drug (Prevention-1 and Treatment-1) showed lower signs of inflammatory.
Mm Amiri, Z Jadali, Sa Mirshafie, A Sarrafnezhad, M Rasoolinejad, M Ravanbakhsh, M Rohani , Ma Boyer, Ar Salehi Nodeh,
Volume 3, Issue 3 (25 2010)
Abstract
Background and Aim: The present study was designed to compare the cell death, circulating levels of tumor necrosis factor-α and tumor necrosis factor type-I receptor in Iranian patients with sepsis and normal controls.
Materials and methods: Twenty-two patients with sepsis were included in this study. After blood collection, the serum circulating levels of TNF- and TNFRI measured with ELISA kits. The PBMCs isolated from blood samples and proportion of apoptotic cells measured by flowcytometry at the time of blood draws (0 time) and after 24-h incubation. PBMCs incubated at 37°C in culture (spontaneous apoptosis) and in the presence of rTNF that is capable of inducing apoptosis in activated T cells expressing the TNF family of receptors.
Results: PBMCs obtained from the patients showed significantly higher (P<0.001) proportion of apoptotic cells than PBMCs of controls at 0 time, indicated that a higher fraction of PBMCs were undergoing apoptosis in vivo in patients but not in controls. After 24-h incubation, spontaneous ex vivo apoptosis of PBMCs was nearly as high as that of TNF- induced apoptosis, indicating that activated T cells had been preprogrammed in vivo to die.
Discussion and Conclusion: The circulating levels of both TNF- and TNFRI showed significantly higher in patients (P<0.001) than controls and this increase is proportional (r=0.908) in both indicating that TNFRI may have a protective effect in the early stage of sepsis.
Sh Alizadeh, S Kaviani, M Soleimani, Aa Pourfathollah, N Amirizadeh, F Kouhkan, S Abroun, M Noruzinia,
Volume 4, Issue 3 (20 2011)
Abstract
Background and Aim: MicroRNAs (miRNA) are small noncoding RNA molecules that transcribed by RNA polymerase II. After biogenesis, these molecules act by incorporation into the RNA-induced silencing complex (RISC). MiRNAs are involved in multiple physiological and pathological processes such as proliferation, differentiation, apoptosis and cancer.
Recently several studies reported down regulation of mir-150 during erythropoesis. Since hemoglobin expression is valuable indicator of erythroid differentiation we evaluated the mir-150 downregulation effect on alpha chain expression by Quantitative RT-PCR.
Materials and Methods: K562cells were grown in RPMI1640 in standard condition. K562 cells were transfected by microRNA 150 Inhibitor using transfection kit .Mir-150 downregulation was confirmed by miRNA Real time PCR, followed by Q-RT-PCR to investigate the alpha chain expression changes.
Results: By relative QRT-PCR the alpha chain expression was increased 10 folds in comparison to untransfected and scramble cells. Furthermore, the differences were statistically significant (P<0.05)
Conclusion: Elevation of alpha chain expression in our study showed that mir-150 downregulation has a crucial role in erythroid differentiation and can introduce as a novel marker in alpha thalassemia. Further researches to find out the detail mechanism and miRNAs genes target could improve our knowledge about miRNAs potential in management of diseases and their applications in gene therapy and regenerative medicine.
Esmaeel Masoudian, Jamil Sadeghifar, Yusef Masoudian, Moslem Salehi, Mojgan Amiriyan Zadeh, Meysam Mousavi,
Volume 6, Issue 5 (13 2013)
Abstract
Background and Aim: Hospital internal evaluation is considered as one of the most important steps in strategic planning. Therefore, besides the recognition of the weaknesses and limitations of the organization, especially affecting issues on the performance, the responsibility of the organization will be defined. This study was performed for the assessment of internal environment of the Gachsaran's Shahid Rajai Hospital based on Weisbord Organizational Diagnosis model.
Materials and Methods: In a cross-sectional study, 123 hospital staff were selected using random sampling formula. Data was collected using Weisbord Questionnaire which consisted of 35 questions in seven areas. Data analysis was conducted using SPSS statistical software and the t-test.
Results: Among six variables studied, variable communication with 3/15 ± 1/25 mean and standard deviation has the best situation and reward mechanism with the mean and standard deviation of 4/59 ± 1/32 was the worst. There was a meaningful difference among all variables except for the leadership variable.
Conclusion: Based on the findings of this study, Gachsaran's Shahid Rajai hospital has strength in the fields of goals, organizational structure, coordination, and internal organizational communication
Hossein Dargahi, Fardin Amiri , Mahsa Akbari, Reza Dehghan,
Volume 7, Issue 4 (11-2013)
Abstract
Background and Aim: Employees suggestion plan (ESP) is designed to encourage and improve employees’ participation in developmental planning. The establishment of this system needs cultural, individual and structural preparedness. This study is aimed to determine organizational preparedness in Tehran University of Medical Sciences (TUMS).
Materials and Methods: This research was a cross-sectional, descriptive and analytical study conducted in TUMS headquarters in Tehran, Iran. The heterogeneous sample of this study consisted of 155 employees. They were asked to fill out a researcher-made questionnaire to assess their attitude towards organizational preparedness for ESP establishment. The validity and reliability of the questionnaire were confirmed. The data were analyzed by SPSS, and descriptive results were presented. The data were also analyzed by Friedman and ANOVA statistical methods.
Results: Most of the employees had a positive attitude towards the existence of individual and cultural preparedness for ESP establishment in TUMS. However, they believed the desired structural preparedness for this process did not exist.
Conclusion : The desired organizational preparedness for ESP establishment exists in TUMS, although structural preparedness is not desirable. Therefore, it is suggested that necessary modifications should be made in TUMS organizational structure for effective ESP implementation.
Mohammad Rasoul Tohidniya, Fatemeh Amiri, Karim Khoshgard, Zeinab Hormozi Moghadam,
Volume 10, Issue 6 (3-2017)
Abstract
Background and Aim: More than 80% of patients need to take x-rays during their diagnosis and treatment stages. Due to the biological effects of ionizing radiation, observance of radiation protection principles are necessary. The observance of radiation protection principles in intensive care units at Imam Reza hospital of Kermanshah in 2014 was evaluated in this study.
Materials and Methods: In this cross-sectional study which was performed by census method, performance of 38 radiographers working in target center was investigated regarding the following of the principles of radiation protection in respect of patients, nurses, radiographers, and other clients in intensive care units. Data collection tool included a questionnaire and a checklist of 31 principles of radiation protection.
Results: The overall level of observance of radiation protection principles in intensive care units was at an appropriate level (94.7%) in 36 radiographies. The highest and lowest levels of principle observance of radiographers were in respect to themselves (94.7%) and nurses in the intensive care units and other clients (26.3%), respectively.
Conclusion: According to results in this study, radiation protection principles observance by radiographers during portable radiography examinations respect of themselves is appropriate but respect of other nurses is not satisfactory. It seems that it can be improved to 100% of the optimum level by equipping intensive care units to protective equipment, setting some obligations to use them, and controlling and continuous monitoring of protective measures of radiographers.
Sajjad Sistani, Mahdieh Raeeszadeh , Ali Akbar Amiri,
Volume 11, Issue 3 (9-2017)
Abstract
Background and Aim: Due to the importance of infertility caused by oxidative stress induced by nicotine, this study was to evaluate the effect of alfalfa extract in contrast with the nicotine on ovarian tissues in rats.
Materials and Methods: Twenty-four adult female rats were randomly divided into 4 groups. Control group received no treatment; nicotine (0.2 mg/kg) was injected to T1 subcutaneously; and nicotine plus hydroalcoholic extract of alfalfa was prescribed to T2 and T3 orally for 25 days at 250 and 500 mg/kg, respectively. On the last day, the animals were weighed. After euthanizing the animals, their ovaries were removed and weighed. Right ovary was used for MDA measure and left ovary was fixed and stained to count the primary, secondary, graafian, and atretic follicles and corpus luteum (CL).
Results: Body weight in T1 (219 gr) decreased by 10 percent, and the average compared with that of the control group, T2 and T3 was significant. The highest ovarian weight was observed in T3 group (146.66±8.94mg). In T3, the average of primary and graafian follicles and CL was higher than that of T1, but atretic follicle was lower than that of T1 group. The MDA concentration in the control group (0.35±0.01 µmol/ml) was less than that in the other groups, but the TCA in T3 (821.18±3.25 µmol/ml) was significantly more than that in T1 group (708.85±12.44).
Conclusion: The hydroalcoholic extract of alfalfa can reduce the oxidative stress caused by nicotine on ovarian tissue and probably improve fertility status.
Alireza Ahmadnezhad, Mohamad Sadegh Sangari, Ali Bozorgi-Amiri ,
Volume 11, Issue 6 (3-2018)
Abstract
Background and Aim: Nowadays, e-procurement systems have provided many opportunities to improve supply and procurement activities in healthcare industry through Internet-based electronic communications for supplier-buyer interactions. Considering the fact that the implementation of these systems is not successful in many cases, extensive preparation in relevant areas is necessary before implementation. This paper aims to present a framework of key readiness factors of hospitals for the adoption of e-procurement system.
Materials and Methods: This study was an applied descriptive survey. The framework of readiness factors was developed based on an extensive review of literature and e-readiness models as well as opinions of experts in the field of information technology, procurement, and healthcare systems. The proposed framework was applied in a case study of a specialty hospital located in Tehran in 2016. The data were collected using a questionnaire, and Fuzzy Cognitive Map (FCM) method was used for modeling and analysis of the identified factors.
Results: In this research, a comprehensive framework of critical readiness factors of hospitals for e-procurement adoption was developed comprising five main components: management, technology, process, human resource, and environment. Environmental and managerial factors were identified as the most important readiness determinants of the case hospital, and among various factors, managers' expertise in IT, IT infrastructures of hospital, and continuous monitoring of system's performance are of higher priority.
Conclusion: This paper provides guidance for more accurate planning to improve readiness and successful adoption of e-procurement systems in hospitals by identifying the most important influential readiness factors.
Arash Rashidian, Efat Mohamadi, Taraneh Yousefinezhadi, Elham Dadgar, Sedigheh Salavati, Zahra Beigom Seyed Aghamiri,
Volume 12, Issue 5 (Dec & Jan 2019)
Abstract
Background and Aim: The starting point for any research is the problem-solving and Research Needs Assessment is needed to identify the underlying issues. This study was conducted to determine the research priorities of the Deputy of Health of Tehran University of Medical Sciences.
Materials and Methods: The present study was an applied study that was designed and implemented in five stages; 1. holding a workshop to teach nominal group technique; 2. Carrying out interviews and the primary extraction of research priorities; 3. Conducting the first round of nominating sessions; 4. holding the second round of nominal group meetings, 5. Finalizing research prioritization titles. Data were analyzed by Excel and Spss version 19 software.
Result: This study was conducted with the participation of 38 people. At first, 1039 minutes of interview, 258 original research titles were extracted. Initial research titles were scored during the 4 sessions. At the end, 75% of the participants rated the 21 study points as 7-9, which were considered as research priorities. The titles "Investigating the root causes of maternal death" was the most priority and "the assessment of the effectiveness of the screening of hypothyroidism" was the least priority.
Conclusion: According to findings, there is consensus among stakeholders on research priorities that require investment in generating knowledge related to health goals. Managing the research resources of the organization towards implementing these priorities will lead to a rational allocation of resources for the production of knowledge and applied products, and ultimately to improve the health of the population.
Elahe Behmani, Rastegar Hoseini, Ehsan Amiri,
Volume 14, Issue 6 (Feb & Mar 2021)
Abstract
Background and Aim: Multiple sclerosis (MS) is a progressive disease of the central nervous system, of which the symptoms and problems reduce the quality of life. Recent research has identified sport exercises as an important part of healthy lifestyle in reducing the symptoms of the disease and improving the quality of life; however, the most effective type of exercise is not yet clearly known. The aim of this study was to provide information about the beneficial effects of exercise in MS patients and guidelines for prescribing exercise programs for them.
Materials and Methods: This article is an overview of the ways different sport exercises affect MS. To access scientific articles, databases of PubMed, SID, Google Scholar, and Mag Iran, and the keywords including multiple sclerosis (MS), aerobic training, resistance training, and combined training were used.
Results: Recent reports show that different types of sport exercises lead to a significant increase in the improvement of MS symptoms, although there are many discrepancies between researchers in prescribing different exercise programs (various training protocol, duration, and intensity). However, according to the results of studies, regular moderate-intensity exercise training leads to the functional benefits and improvement and control of the disease process without exacerbation of inflammation through various physiological mechanisms. thus, contrary to popular belief, modulated exercise training can have beneficial effects on MS patient.
Conclusion: Based on the findings of the present study, regular exercises (aerobic, resistance and combination) with moderate intensity improve the symptoms of MS and increase the quality of life.
Nazli Ebrahim Netaj, Maryam Rezaei Dastjerdi, Saham Ansari, Kamran Amirian Chayjan, Mahdi Sepidarkish, Jalal Jafarzadeh, Akbar Hossein Nejad, Mojtaba Taghizadeh Armaki,
Volume 16, Issue 4 (Oct 2022)
Abstract
Background and Aim: Denture stomatitis is the most prevalent oral mucosal lesion among denture wearers. Because there have been multiple reports of resistance of Candida species to antifungal drugs in the last two decades, if the antifungal properties of Achillea millefolium and Trachyspermum ammi are validated, these compounds may be a suitable adjuvant drug along with the use of common antifungal drugs. Therefore, the current study aimed to assess the antifungal activity of alcoholic extracts of Achillea millefolium and Trachyspermum ammi against Candida albicans isolated from denture stomatitis.
Materials and Methods: Antifungal sensitivity of 50 isolates of C. albicans with the origin of denture stomatitis to the alcoholic extracts of Achillea millefolium and Trachyspermum ammi plants as well as the antifungal drugs miconazole and nystatin was determined by broth microdilution method and according to CLSI-M27S4 guidelines. The range of dilution for all compounds was 0.016-16 μg/ml. A concentration of compounds that showed at least 50% growth inhibition as compared to the positive control group was considered MIC (minimum growth inhibitory concentration). Statistical analysis was done using SPSS software and the significance level was considered as P<0.05.
Results: The MIC ranges in microbroth dilution method for the antifungal drugs miconazole, nystatin, as well as the alcoholic extracts of Achillea millefolium and Trachyspermum ammi plants on C. albicans, were close to each other, indicating that their effectiveness against C. albicans species does not differ significantly (P<0.05). The Achillea millefolium methanolic extract had the highest and lowest MIC values, with an average of 2.67±2.55 μg/ml and 0.067±0.057 μg/ml, respectively. A significant difference (P<0.001) was observed when the MICs outcomes the herbal alcoholic extracts and antifungal drugs were compared.
Conclusion: Based on the obtained MICs, Achillea millefolium and Trachyspermum ammi alcoholic plant extracts have a lesser efficacy than the antifungal drugs, but even though they may have a lower MIC and more effectiveness than other chemical drugs.
Saeed Nateghi, Ali Ganjali Khan Hakemi, Soheila Damiri, Samira Raoofi, Elham Haghshenas, Sara Akhavan Rezayat, Shamsi Ekhtiyar, , Maryam Radin Manesh,
Volume 16, Issue 5 (Dec 2022)
Abstract
Background and Aim: Effective monitoring and evaluation of human resources in countries require an agreed set of indicators and measurement tools. Due to the existence of different payment mechanisms, this study aimed to identify performance evaluation indicators in hospitals affiliated with the Tehran University of Medical Sciences.
Materials and Methods: A qualitative phenomenological study was conducted in 2022. Data were collected using semi-structured interviews, purposive sampling, and participation of 23 members of the Senior executives and financial team of hospitals affiliated to Tehran University of Medical Sciences and analyzed by content analysis method using MAXQDA-10 software.
Results: Twenty-three experts participated in this research, 78.2% were men and 21.7% were women, and a total of 526 final codes were identified and according to the balanced scorecard management tool in 4 main themes of finance, customers, internal processes, and growth and Development. Also 8 sub-themes of resource efficiency with 86%, medical tourism with 52%, professional ethics with 65%, satisfaction with 78%, accreditation with 48%, diagnosis and treatment with 78%, education with 56% and The research was categorized with 78%.
Conclusion: The provision of optimal medical services requires managers to be aware of the performance of subordinate personnel, which makes it possible to choose the appropriate criteria, develop performance evaluation systems and conduct correct evaluation, informing Doctors regarding the indicators considered for more accurate evaluation are among the suggestions that can be a solution to the existing problems. Another important point considering the limited available resources is the role of doctors in the field of health tourism to which attention will lead to an increase in financial resources.
Fardin Amiri, Arash Khajehvand, Sedigheh Hannani, Nemamali Azadi,
Volume 16, Issue 5 (Dec 2022)
Abstract
Background and Aim: Surgical site infection (SSI) is one of the most common health-care associated infections. Using proper antiseptic solutions for preoperative surgical site skin preparation (skin prep) is one of the methods to reduce SSIs. The purpose of this study was to compare the effect of preoperative surgical site skin preparation with povidone-iodine and chlorhexidine-gluconate on the rate of SSI in laparotomy patients.
Materials and Methods: A total of 70 Laparotomy surgery patients who referred to Firoozgar hospital in Tehran from May to September of 2021 were included in this clinical trial. Patients were randomly allocated into two groups which were treated with povidone-iodine(PVI) or chlorhexidine-gluconate (CHG) for surgical site skin prep. Skin prep was done with standard rotational method in two steps by the researcher for each group by using of PVI and CHG. SSI incidence was assessed by a researcher-made check list and also over post-surgical follow up visits by the surgeon. We used Fischer’s exact test, t-test, Chi-square and Cochrane’s Q-test to analyze the collected data.
Results: SSI was seen in five patients (14.29%) of PVI group and one patient (2.86%) of CHG group. Although the SSI incidence in PVI group was 5.54 times more than CHG group, still the difference wasn’t statistically significant (P=0.198). Comparing the incidence of SSI’s in 24 hours after surgery (0%) and 30 days after surgery (8.57%) in both groups revealed that using these antiseptics for skin prep was effective in preventing SSI (P<0.001). SSI incidence was also associated with two days of patient’s hospital admission time (P=0.001).
Conclusion: The result of this study revealed that the occurrence of SSI in PVI group was 5.54 times more than CHG group. However, the difference was not statistically significant. So both of these antiseptics can be used for surgical site skin prep.
Erfan Amiri, Hossein Hooshyar, Hossein Nazemorraaya, Mohammadreza Shiee, Sima Rasti, Gholam Abbass Moosavi,
Volume 17, Issue 5 (12-2023)
Abstract
Background and Aim: Toxoplasma gondii is one of the important food-borne parasitic pathogens that infect humans and a wide range of warm-blooded animals. Consumption of poultry meat, especially chicken, is a potential risk of transmission of toxoplasmosis to humans. This study aimed to determine the prevalence of T. gondii infection in industrial broilers referred to the Kashan poultry abattoir, Iran, in 2023.
Materials and Methods: This cross-sectional study was performed on 114 brain and heart samples of industrial broilers were randomly collected from Kashan poultry abattoir. Two prepared direct smears from each sample were stained with Giemsa stain and examined microscopically for the presence of tissue cysts of T. gondii. The genomic DNA was extracted using a commercial kit. PCR method was used for detection of the B1 genome of T. gondii using specific primers. The PCR product was evaluated by electrophoresis on a 1.5% agarose gel. The results were analyzed with descriptive statistics using SPSS software.
Results: Of 114 chicken samples, 65 (57%) and 49 (43%), were male and female respectively. Totally, 12 samples (10.5%) were positive for T. gondii infection. T. gondii DNA fragments were detected in 8 (7.06%) of the samples. Microscopy examination revealed T.gondii in 6 (5.26%) samples. All infections were related to brain samples, and no infection was detected in heart muscle samples.
Conclusion: Infection with T. gondii is considerable in broilers in the Kashan region. Therefore, preventive measures such as training people to properly cook meat before consumption and avoiding eating raw or under‑cooked poultry meat products are recommended to prevent human infection to T. gondii. In order to stop life cycle of this parasite, avoiding using raw bird meat for feeding pets such as cats is recommended.
Sedigheh Hannani, Parsa Farmahin Farahany, Fardin Amiri,
Volume 18, Issue 3 (5-2024)
Abstract
Background and Aim: The usual trainings are not enough to acquire the knowledge and skills of operating room students to play the role of scrub and mobile person, especially in complex and specialized surgeries. This research was conducted with the aim of determining the effect of designing, implementing and evaluating the protocol before, during and after Whipple surgery and its effect on the knowledge, attitude and clinical skills of surgical technology students of Iran University of Medical Sciences.
Materials and Methods: This research was a semi-experimental study of pre- and post-intervention type, during which 50, fifth and seventh semester undergraduate students of surgical technology were selected and trained using the designed protocol. The content of the protocol included the latest principles of Whipple surgery technology in the field of surgical anatomy, pathology of the digestive system and pancreas, diagnostic procedures and preparations before Whipple surgery, the procedure of Whipple surgery and the post-surgery phase and the recovery period of Whipple surgery. Before and after the training, the amount of knowledge, attitude and clinical skills of the students were evaluated and compared using a questionnaire and an observational checklist. The data were analyzed using paired t-test, non-parametric Wilcoxon test and analysis of covariance test in SPSS software.
Results: The results of this study showed that after using the designed educational protocol, the knowledge, attitude and clinical skills of surgical technology students increased. That is, the use of the designed educational protocol was effective on the level of knowledge, attitude and especially the clinical skills of the students. So that a statistically significant difference was observed in the average scores of the knowledge, attitude and clinical skill test of the students before and after training (P<0.05).
Conclusion: Based on the results of this study, designing and using educational protocols is an effective method in the process of teaching and evaluating the level of knowledge, attitude and clinical skills of students in complex and specialized surgeries such as Whipple surgery. Therefore, the use of educational protocols designed in the process of teaching students is recommended to all professors and educational officials of surgical technology.
