Journal of

Background and aim: One of the most important technological advancements for monitoring patients -- especially in anesthesia, recovery, and Intensive Care stages -- is pulse oximetry which can measure the oxygen saturation of arterial blood (spo2) and show hypoxemia before it is clinically observable. Therefore, it is necessary for the individuals who are responsible for treating and taking care of patients in critical stages to have sufficient knowledge about it. If they lack the required knowledge, they should be trained using appropriate methods.

Materials and methods: Upon referring to the ORs and the ICUs, a questionnaire was distributed among the medical and paramedical staff (doctors, nurses, anesthesia technicians, etc.) to assess their knowledge of pulse oximetry. The questionnaire had a part for demographic data and 20 true/false items and was to be filled in by the subjects in 15 minutes. After the data were collected and analyzed, the subjects' level of knowledge about pulse oximetry was assessed in terms of age, sex, academic degree, their experience with the device, and how they had obtained information about pulse oximetry. The variable was measured on a 0-20 scale. The subjects would get one point for every correct response and the total number of correct responses would constitute each individual's score.

Results: The results of the study show that only 15.8% of the participants had a high level of knowledge of pulse oximetry. The figure was 61% for those having medium-level knowledge and 23.2% for the individuals with low knowledge. In other words, for the optimal use of the device, 84.2% of the subjects need training. The results also indicate that the subjects' level of knowledge is positively related to their sex, academic degree, and how they acquired their knowledge. In fact, female subjects, paramedical staff, and those who had obtained information from colleagues and the companies selling the device had a lower level of knowledge needed for using the device properly. However, no statistically significant difference was found between the subjects' knowledge of pulse oximetry and their age and experience with the device.

Conclusion: Based on the findings, it is necessary for the female members of paramedical staff to be trained in classes and/or be provided with pamphlets on the issue. 

Background and Aim: Acute promyelocytic leukemia (APL) is associated with the t(1517) ,fusing promyelocytic leukemia (PML) and retinoic acid receptor-a (RARa) genes. This disease is uniquely sensitive to treatment with all-trans retinoic acid (ATRA) and highly responsive to conventional chemotherapy. The t(1117)(q23q21) abnormality associated with a PLZF-RARa rearrangement is the commonest of the alternative translocations accounting for less than 1% APL. Blasts from PLZF-RARa cases have been found to be resistant to the differentiating effects of retinoids. In this study we aimed to determine the PLZF-RARa and fusion genes in patients with APL morphology who referred to Hematology-Oncology and BMT research center, Tehran Shariaty Hospital in 2006.

Materials & Methods: Peripheral blood and/or bone marrow samples were taken from 200 patients with APL morphology and 200 patients with other subtypes of AML. The mono-nuclear cells were enriched by centrifugation over a ficoll-isopaque gradient. RNA extracted by Trizol or TriReagent and then reverse transcribed to cDNA using random primers. PCR performed using specific primers for each fusion. PCR products electerophoresed on a 2% agarose gel containing 0.05% ethidiume bromide.

Results: In 2 (1%) patients with APL-morphology the RT-PCR analysis showed PLZF-RARa fusion transcripts.

Conclusion: It can be concluded that RT-PCR is a rapid and sensitive method for detection of abnormal fusion genes in leukemia and allows the definition of a correct strategy for treatment and subsequent minimal residual disease monitoring

Conflict management is a kind of management which could be administered the organization with the best ways and create balance between organization and staffs and  eliminates the conflict. Generally , conflict management is the process of conflict roles recognition between intergroups and intragroups and use of conflict techniques for eliminate or simulate conflict for organizational effectiveness.
This research is aimed to introduce conflict management and how to use its strategies to modify this phenomenon.
This research shows that organizational conflict have both instructive and destructive results. Managers should use conflict management in every organization. Most conflict management strategy used to control conflict is collaboration between managers and staffs. Conflict management has important role to make managers successful . Although, a minimum of conflict is appropriate in every organization but no managers agree with anarchism in his organization