Showing 9 results for Bahar
H Ghafari , P Karimzadeh , B Chahardouli , K Alimoghdam , A Ghavamzadeh , H Dargahi , B Bahar , Gh Togeh , F Nadali ,
Volume 3, Issue 2 (21 2009)
Abstract
Background and Aim: The JAK2 is an acquired mutation that is observed in majority of patients with classical Philadelphia-negative Myeloproliferative neoplasms that include polycythemia vera (PV), essential thrombocythemia (ET), primary myelofibrosis (PMF). This acquired mutation is characterized by a G to T transversion at nucleotide 1849 in exon 12 of the JAK2 gene, leading to a substitution of valine to phenylalanine at amino acid position 617(V617F) of the JAK2 protein, and result in constitutive JAK2 activation that promotes hypersensitivity to growth factors and cytokines.
Materials and Methods: In this study we evaluated RNA from 58 patients with MPNs and statistical analysis was done with mann whitney test. The mutation detected by AS-PCR. In addition, 3 samples were sequenced in Mille gen company.
Results: 46 patients:86.6%(26/30) of those with polycythemia vera, 53.3% (8/15) of those with essential thrombocythemia,61.5% (8/13) of those with idiopathic myelofibrosis polycythemia vera patient carrying the mutation displayed higher levels of WBC (p=0.03). on the other hand,16 out of 26 JAK2V617F positive patients were female there is a demonstrate correlation between the presence of a mutant allele and female gender. The difference in other groups were not significant.
Discussion and Conclusion: The JAK2V617F mutation has been detected in the vast majority of patients with polycythmia vera (65-95%) and in a lower frequency in patients with essential thrombocythemia (23-57%), idiopathic myelofibrosis (23-57%) and chronic myeloid leukemia 19% (3/16 CML Ph-). Detection of the mutation is helpful in differential diagnosis, prognosis, and prediction of therapeutic response.
Roohollah Askari, Reza Goudarzi, Hossein Fallahzadeh, Bahareh Zarei, Arefeh Dehqani Tafti,
Volume 6, Issue 3 (7 2012)
Abstract
Background and Aim: Paying attention to efficiency of cost and performance in hospitals as the largest and the most costly performing unit of the health care systems is very crucial. This study aimed to assess the efficiency of hospitals related to Yazd University of Medical Sciences (YUMS).
Materials and Methods: In this study, the efficiency of Hospitals of YUMS was assessed by Data Envelopment Analysis method during years 2000- 2008. The variables were of two types: output variables including the percentage of occupied beds, inpatient days and the number of surgical procedures and input variables were number of active beds, nurses, medical staff and other personnel. The data was analyzed using Deap2.1 software.
Results: Average of technical, management and scale efficiency of hospitals was 0.958, 0.986 and 0.963 respectively. We concluded that the capacity of efficiency promotion in hospitals is increasable up to 5%. In addition, the nurses as one of the most important input variables, had the most apparent slack inputs.
Conclusion: Although the level of efficiency was optimal and there was little unused capacity for increasing efficiency in hospitals, however, managers should plan to increase the efficiency. Finally, assessing the effect of variables such as service quality and patient satisfaction on hospitals efficiency is recommended.
Farzad Faraji Khiavi , Mansour Zahiri , Kambiz Ahmadi Angali , Bahareh Mirzaei , Mohammad Veisi, Marjan Arab Rahmatipour ,
Volume 8, Issue 2 (7-2014)
Abstract
Background and Aim: Information literacy is a set of skills
required to identify rightful information resources and access to them. These skills are empowering goal oriented use of information
resources. This study aimed to determine the ability rate of information
literacy among health services administration students in Jundishapur University of Medical
Sciences based on SCONUL seven pillars model.
Materials and
Methods: This cross-sectional
descriptive-analytic study was conducted using a questionnaire developed based
on SCONUL information literacy seven pillars model. Validity of the
questionnaire was confirmed through content analysis and coefficient of
Chronbach’s alpha was 0.93. The study population included students of health services
administration in Ahvaz Jundishapur University of Medical Sciences in 2013. The
sample size included 40 cases collected randomly. Data
analyzed through SPSS descriptive
statistics and non-parametric statistical tests.
Results: The mean score for the
studied components of information literacy abilities among the study population
was 0.5±0.43. Information Literacy score among freshmen was significantly
different from other students (P<0.03). Students who passed Computer Basics
and Research Methodology educational courses showed significant differences
from other students in the information management (P<0.01).
Conclusion: Given the increasing development in information
technology, the need to develop information literacy skills is considerable
especially among those who are going to be engaged in the health sector.
Although studied students’ information literacy estimated relatively well, it
seems necessary to take measures to improve their information literacy in all
components.
Seyed Mohsen Tabatabaei , Masumeh Habibi Baghi, Seyedeh Bahareh Kashian, Mahmood Biglar,
Volume 9, Issue 5 (2-2016)
Abstract
Background and Aim: Employees are an organization's greatest assets and organizational performance is dependent to employee’s performance. Presence of inefficient employees can make other employees to be less productive. To improve inefficient employees to high performance level, it is necessary to analyze the performance of employees. This study aims to identify and determine poor performance dimensions and cluster inefficient staffs.
Materials and Methods: This study was an analytical and descriptive research. The research made questionnaire developed for data collection and Principal Component Analysis (PCA) and Cluster Analysis (CA) techniques in SPSS used to analyze the research data.
Results: The PCA results showed that six poor performance dimensions were behavioral problems, low results, lack of self-efficacy and creativity, sabotage, postponing, and individualism. The CA results declared that poor performers can be classified to five clusters include poor behavior, lazy, jobber, poor ability, marginal, managers believed that root of employees’ in inefficiency attributed jobber, poor ability, and lazy employees to internal causes, and attributed bad behavior and marginal employees to external causes.
Conclusion: The type of inefficiency and its dimensions should be identified in order to make effective decisions for inefficient employees. Employees clustering propose a new attitude toward inefficiency differentiation comparing to literature, and this five group clustering based on empirical data expected to be more applicable in practice.
Seyedeh Bahareh Kashian, Abbas Afrazeh, Seyed Mohsen Tabatabaei, Mahmood Biglar,
Volume 10, Issue 5 (1-2017)
Abstract
Background and Aim: Modeling of organizational knowledge creation process is one of the key areas of research in knowledge management. The aim of this paper was to determine solutions for developing and improving evolutionary knowledge creation model based on the model validation results in real world.
Materials and Methods: This study was an analytical and empirical research that was done by multi case study and simulation strategy. The committee was formed to collect information from various source of data including organizational documents and interview with senior managers about knowledge creation history for 5 years in Development and Planning Management department of Tehran University of Medical Sciences. Data analysis was done using descriptive statistics and qualitative analysis. Also, the mathematical formulation was analyzed using simulation in Excel.
Results: In most of analyzed knowledge creation cases, knowledge absorption from external source through changing managers or employing consultant following integration with exist knowledge was occurred. Also, simulation results show that, mathematical relations were not well defined and changing them makes results more acceptable.
Conclusion: Knowledge grow in organization has occurred through three ways including planned knowledge creation based on managerial decisions, planned knowledge absorption based on managerial decisions, and random knowledge creation mechanism, and all of them have impact on essential knowledge contents.
Arman Bahari, Behnoosh Moody,
Volume 15, Issue 4 (oct & Nov 2021)
Abstract
Background and Aim: Increasing the use of smartphones, improving the state of World Wide Web, and also the need for flexibility in the education process have made the implementation of e-learning in human society inevitable, eliminated time and space limitations, and provided equal education. However, the pace of its creation and development, especially in universities and higher education centers in developing countries such as Iran, is very slow. Therefore, the present study aims to investigate the factors affecting the creation and development of e-learning from the viewpoint of students of Zahedan University of Medical Sciences.
Materials and Methods: This is an applied and descriptive-survey study. The sample includes 313 students studying at Zahedan University of Medical Sciences during 2016-2017, who were selected by simple random sampling. Data were collected using a researcher-made questionnaire and analyzed using statistical tests and SPSS software.
Results: The findings show that the six selected factors of this study affect the creation and development of e-learning from the viewpoint of Zahedan University of Medical Sciences students. From the highest to the lowest effect, these factors include the quality of information and content (4.25), learners’ willingness (4.11), system quality (4.10), facilitators (4.05), student-professor interaction (3.98) and professor quality (3.84).
Conclusion: According to the findings of the present study, it can be concluded that policy makers and university administrators, considering the importance of each factor, invest and develop e-learning to provide better services to students and faculty.
Seyed Amir Reza Nejat, Mahmoud Bigler, Seyedeh Bahareh Kashian,
Volume 16, Issue 1 (3-2022)
Abstract
Background and Aim: Intellectual capital, with its basic knowledge nature, is an intangible, strategic, unique and competitive advantage resource. The purpose of this study is to investigate the current state of intellectual capital maturity in the field of management and planning of Tehran university of medical sciences.
Materials and Methods: This research was applied in terms of purpose and with a quantitative approach in 1400 and a questionnaire was used to collect information. The statistical population is the middle and basic managers of the Vice Chancellor for Resource Management Development and Planning. Using Morgan table, 57 people were randomly selected and analyzed by t-test and non-parametric statistical tests using SPSS software. Has been. The content validity of the questionnaire was obtained by examining the research background and obtaining the opinions of experts, and the Cronbach’s alpha coefficient was used to assess the reliability, the value of which was 0.874.
Results: Statistical tests show that the five levels of intellectual capital management maturity follow a nonlinear pattern and the level of realization of the initial level characteristics, ie lack of intellectual capital structure, is higher than acceptable, but the statistical test of other levels of maturity Included; Managed, defined, quantified and optimal management is not significant at the significance level of 0.05.
Conclusion: The current situation of intellectual capital in the study population indicates that management is unaware of the importance of intellectual capital and no action has been taken to implement the knowledge capital management process. Although there is a lot of necessary infrastructure in the Vice Chancellor, however, insufficient understanding of the capabilities of intellectual capital management as a strategic resource is evident in this research. To reach the defined level and the next levels, the organization needs to identify, activate and direct the intangible source and then quantify, standardize and manage quantitatively and analyze the strengths and weaknesses and finally the continuous improvement of processes and Focus on innovation.
Omid Ali Gholami, Jamil Sadeghifar, Bahareh Kabiri, Shabnam Ghasemyani, Sadegh Sarhadi, Reza Jorvand,
Volume 17, Issue 4 (10-2023)
Abstract
Background and Aim: Health literacy is recognized as a key determinant of health and is a central focus of public health policy strategies. The present study aimed to assess the health literacy level and identify the factors influencing it among the clients of comprehensive health service centers in Ilam city.
Materials and Methods: In 2022, a descriptive-analytical study was conducted to examine 429 clients aged 18-65 years who visited comprehensive selected health service centers in Ilam city. For adults the data collection tool used was the Helia health literacy questionnaire. Sampling was conducted in nine clusters, with each cluster consisting of 50 samples. The data was analyzed using SPSS software, which included descriptive statistical tests, Pearson’s correlation coefficient, and one-way analysis of variance, with a significance level set at 0.05.
Results: Based on the results, the average health literacy score was 80.16 ± 16.50. In terms of health literacy, 18.97% of people had inadequate or not very adequate health literacy, while 44.39% of the participants had excellent health literacy. The average health literacy scores across different dimensions are as follows: access to health information 65.74, comprehension of information 81/81, reading information skills 12.74, evaluation of information 05.75, and decision making and behavior based on information 61.92. A significant relationship was observed between job, education, and income variables and various dimensions of average health literacy (p-value≤0.001). However, there was no significant relationship between general health literacy and age, gender, and place of residence (P≤0.05).
Conclusion: The results of the present study demonstrate that vulnerable groups have significantly lower literacy levels. Furthermore, given the impact of education on enhancing people’s health literacy, it is advisable to leverage mass media, social networks, and educational centers to enhance literacy levels as a potential factor in community health.
Seyedeh Nasim Mirbahari, Sina Salari, Shabnam Shahrokh, Mohammadreza Zali, Mehdi Totonchi,
Volume 18, Issue 1 (3-2024)
Abstract
Background and Aim: Oncolytic viruses, as novel and advanced tools in the field of treating various types of cancer, have played a very important role in medical developments. The term “oncolytic” refers to the ability of these viruses to destroy and damage cancer cells while preserving the surrounding healthy cells.
Materials and Methods: To conduct this study, a total of 270 initial results were collected through searching in the PubMed, Scopus, and Google Scholar databases from 2012 to 2024. The primary researcher reviewed 68 relevant articles, extracted and summarized the contents, and finally compiled the findings.
Results: The findings from this review study demonstrate that cancer cells possess distinct characteristics that differentiate them from normal cells, including continuous growth signaling, resistance to anti-growth signaling, evasion of apoptosis, increased angiogenesis, and invasion into other body parts. Oncolytic viruses utilize these distinctive features to selectively target and infect cancer cells. Most oncolytic viruses directly eliminate host tumor cells, resulting in viral replication and induction of host antiviral responses. Moreover, these viruses can destroy cancer cells through the production of specific proteins. The cytotoxic potential of oncolytic viruses depends on viral type, genetic manipulation, optimal virus dosage for injection, natural and induced viral tropism, and cancer cell sensitivity to various forms of cell death. The mechanism driving the selective replication of oncolytic viruses in cancer cells likely relates to defects in signaling pathways specific to tumor cells. Phase III clinical trials have demonstrated significant improvements in the treatment outcomes of various cancers, including head and neck cancer, melanoma, glioblastoma, and bladder cancer, through the use of H101 (Oncorine), T-Vec, ECHO-7, and Teserpaturev (Delytact) viruses.
Conclusion: Oncolytic viruses are constructed from various types of viruses and are currently being evaluated in laboratory, preclinical, and clinical stages. The use of these viruses for the treatment of cancer as a new and targeted approach has been proposed, which requires further investigation and achievement of more precise mechanisms for their better performance.
