Showing 7 results for Dehghani
Zahra Kashani Khatib , Ali Dehghanifard , Saeid Kaviani , Mehrdad Noruzinia , Momeneh Mohammadi , Fatemeh Mohammad Ali , Elham Roshandel , Sahar Mohammadi Fateh , Shaban Alizadeh,
Volume 8, Issue 3 (9-2014)
Abstract
Background and Aim: Understanding the molecular mechanisms involved in the increased levels of HbF inducing drugs should be advised for effective induction. The aim of this study was to investigate the molecular effects of the drugs thalidomide and sodium butyrate considered as HbF inducer agents.
Materials and Methods: In this experimental study, CD133+ cord blood stem cells carrying mutations of heterozygous β-thalassemia were isolated and differentiated into erythroid lineage. In order to evaluate the expression of the erythroid markers, CD71 and CD235a, was analysed. For this purpose, the RNA extracted from erythroid precursors at days 6 and 12 of erythroid differentiation and cDNA synthesized, and then the expression of these genes was performed by quantitative Real-time PCR technique.
Results: The results of this study showed the significant effect of thalidomide on erythroid proliferation as compared to sodium butyrate and control group (P<0.05). Also, thalidomide significantly increased CD71expression and decreased CD235a expression as compared to sodium butyrate and control groups (P<0.05).
Conclusion : Thalidomide may play its role on HbF induction by increasing the proliferation of early erythroid precursors.
Raja Al-Huthaifi, Ali Dehghanifard, Saeid Kaviani, Mehrdad Noruzinia, Samira Rezaei, Mehdi Azad, Maedeh Mashhadikhan, Saeid Solali,
Volume 9, Issue 6 (3-2016)
Abstract
Background and Aim: Different regulation processes have an effect on osteoblastic differentiation of mesenchymal stem cells (MSCs), and among them Wnt signaling pathway is particularly desirable. In Wnt signaling pathway, Adenomatous Polyposis Coli (APC) bind to β-catenin and induce its degradation, thereby acting as a negative regulator of canonical Wnt pathway. In this study, gene expression and DNA methylation of APC gene during osteoblastic differentiation were determined.
Materials and Methods: In this experimental study, after the isolation of MSCs, the induction of osteoblastic differentiation was done. To confirm osteoblastic differentiation, alizarin red staining together with the expression of Alkaline Phosphatase (ALP) and osteocalcin as specific osteoblastic markers was performed. APC gene methylation status by MSP (Methylation Specific PCR) and gene expression status of APC gene using Real-Time PCR technique during different times were evaluated.
Results: The results of alizarin red staining and the expression of ALP and osteocalcin confirmed osteoblastic differentiation. In addition, the results showed a significant decrease in the expression of APC gene on the 7th day of osteoblastic differentiation (P<0.05). Also, the results revealed hypermethylation status of APC gene promoter during osteoblastic differentiation.
Conclusion: It seems that the decreased expression APC gene will play an important role in Wnt signaling pathway regulation in different stages during osteoblastic differentiation of bone marrow-derived MSC. Also, according to the results, APC gene promoter methylation will play an important role in controlling gene expression.
Narjes Mirabootalebi, Maryam Ahmadi, Mohammad Dehghani, Shahram Khani, Mohsen Azad,
Volume 10, Issue 5 (1-2017)
Abstract
Background and Aim: Electronic Medical Record system collects and stores laboratory data, digital images and electronic versions. It plays a major role in reducing medical errors and duplication and health care providers immediate access to patient medical records. This study aimed to examine the viewpoints of Hormozgan University of Medical Sciences' administrators on the role of electronic Medical records system.
Materials and Methods: The study was a descriptive-analytical research to examine the viewpoints of Hormozgan University of Medical Sciences' administrators and physicians on the role of electronic medical records system. The study population consisted of 61 managers, matrons and health information managers of Hormozgan hospitals and 121 faculty physicians and residents. Data collection tool was a researcher-made questionnaire. The validity was determined and verified by content validity method and experts' views. Cronbach's alpha coefficient was used for assessing reliability, which was 83%. Data collected from the questionnaires was analyzed using SPSS software and descriptive statistics and analytical statistics.
Results: Results indicated that "data management" (N=146) with 77.5%, "job objectives and processes" (N=160) with 87.9%, "communication" (N=163) with 89.6%, "data privacy and security" (N=152) with 83.1% had the most important roles in the health system.
Conclusion: Generally, managers and physicians attitudes about the role of electronic medical records system in the health system was evaluated satisfactorily. According to the advantages of the system and removing major obstacles in its implementation, a new step would be taken in order to promote health.
Somaye Dehghanisanij, Ismaeil Mostafavi, Hamidreza Zarghami, Hojat Soleimani,
Volume 14, Issue 5 (Dec & Jan 2021)
Abstract
Background and Aim: The field of medical engineering is the flagship interdisciplinary approach in Iran, which, due to its attention to knowledge-based economy, takes a step towards prosperity and smoothing progress and development. The purpose of this study is to investigate the interactions between university, industry and government of Iran in scientific articles in the field of medical engineering using the triple helix model.
Materials and Methods: This is an applied research with a quantitative approach and uses scientometric techniques. The status of dynamic interactions of the main pillars of Iranian innovation in the field of medical engineering in WoS (Web of Science) database has been calculated using the .exe and the 4.exe softwares in the period of 2010-2019, and the transmission degree of uncertainty index in dual and national dimensions has been determined.
Results: The T-index ranking was assigned to university-government(23.38 mb), university-industry(8.47 mb) and industry-government (1.13 mb), respectively, and finally, national interaction(-12.48 mb) was obtained. The interaction between university and industry had an increasing trend and the strongest dual interaction belonged to the university-government. Over the last ten years, national interaction has always had a negative value, which indicates the existence of dynamics in interactions in the national dimension.
Conclusion: The dual university-industry interaction has been increasing in recent years; however, in the long run, the national interaction of the pillars has been facing a declining trend, according to which some science and technology policies, and research and industrial strategies have been proposed as a necessity to promote the university-industry-government innovation network in the field of medical engineering in Iran.
Simin Momenzadeh, Atefeh Zarei, Phd Seyed Ali Akbar Famil Rouhany, Leila Dehghani,
Volume 15, Issue 2 (Jun & Jul 2021)
Abstract
Background and Aim: This study aimed to propose a consistent architecture to design integrated and flexible information systems for the Vice-Chancellor for Research and Technology of Ahvaz Jundishapur University of Medical Sciences (AJUMS).
Materials and Methods: This applied research employed an integrated design based on business system planning (BSP) and James Martin's model for the design of information systems. The statistical population of this study included 27 managers and experts of AJUMS Vice-Chancellorship department for Research and Technology. Data collection was carried out using structured interview, observation, and document analysis. A contrast matrix was then used for data analysis.
Results: In total, 53 processes and 60 data classes were identified. Using a multi-layered architectural model (presentation, process, data and infrastructure), the results were presented in the form of a proposed architecture. In the proposed architecture, 12 subsystems and the relationships among them were identified; such subsystems as library, research activities, sabbatical leave, conference, fellowship, publication, innovation and technology, laboratory information, theses, budget and planning, social subsystem and knowledge-management networks. The results also showed that the level of coverage of the processes, data classes, and objectives by existing information systems were 53%, 50%, and 55%, respectively, and increased to full coverage in proposed or optimal modes.
Conclusion: By identifying the required information systems, it is possible to accurately plan and successfully use these systems in this study. The results of the present study can be used to implement the architecture of information systems of Research and Technology Departments of other universities of medical sciences (UMSs) in Iran, which can have a significant effect on saving cost and time.
Ashraf Dehghani, Maryam Ghanbari Khoshnood, Somayeh Amini Sarteshnizi, Arezoo Farhadi,
Volume 17, Issue 1 (3-2023)
Abstract
Background and Aim: The emergence and continuity of Corona has forced universities and higher education centers to change their educational strategy to take appropriate and consistent action to improve their educational programs. Due to the importance of e-learning and e-learning in response to these conditions, the present study investigated the experience of students of Hamadan University of Medical Sciences from e-learning in the Covid-19 crisis condition.
Materials and Methods: This was a qualitative research with an interpretive phenomenological approach. The purposeful sampling method was used. Semi-structured interviews were used to collect data. After the thirteenth interview, the theoretical saturation of the data was achieved and the interview process with the sixteenth person was completed. In order to analyze the text of the interviews, the Colaizzi method was used.
Results: From the analysis of the obtained data, three main themes: “Communication and interaction” with five sub-themes (lack of proper interaction between student/professor and student/student, lack of motivation, security and mental health, knowledge sharing and efficiency atmosphere in time and cost), “Management of time and learning style” with six sub-themes (low quality of teaching, stress, access and provision of resources, exam health, gaining experience and skills and opportunity to learn again and innovation in education) and “Infrastructure and technical facilities” were extracted with three sub-themes (weak support, ignoring educational equality and promoting media literacy). Weak interaction between professor and student, increasing level of anxiety and individual responsibility to achieve success in learning and weak technical and management infrastructure were the main challenges obtained from these three themes. Providing a platform for research, self-regulation and self-management in learning, increasing the knowledge and skills of information and communication technology are among the opportunities that are included in these themes.
Conclusion: The results of the current research require attention to the approach of interaction and communication between the learner and the learner, to review the methods of teaching and skill-learning, to improve the quality of electronic learning and to prepare suitable infrastructures for optimal use of electronic learning.
Soraya Sayar, Sara Noruzi, Seyed Mohammad Hossein Javadi, Mohammad Sabzi Khoshnami, Sanaz Dehghani, Maryam Pour Hosein, Mahnaz Zamyadi,
Volume 17, Issue 6 (2-2024)
Abstract
Background and Aim: Considering the role of social workers in the health system, the success and stability of organ transplantation, prevention of re-hospitalization of patients and reduction of imposed costs, this study aims to design a protocol for the specialized interventions of social workers in Iran’s medical centers in the transplant process and to create uniformity in practice. Comprehensive services have been provided to patients and their caregivers.
Materials and Methods: The study was conducted in two phases of resource review and qualitative. In the resource review phase, reliable databases were examined, and in the qualitative phase, in order to collect information from Delphi techniques and focused group discussion with the presence of fifteen officials and social workers working in the country’s hospitals and experts and experts. The areas of health and treatment assistants of the Ministry of Health, university professors, medical staff and experts in the field of transplantation and organ donation were carried out. The protocol was sent to eight experienced experts for final review and evaluation, and they were asked to review the protocol in terms of the goal and scope of interventions, stakeholders, development steps, clarity of presentation, accessibility and non-dependence in writing according to the checklist to evaluate.
Results: In this study, the work process of social workers was drawn in three stages before, during and after transplantation. Also, various roles were considered for social workers in three stages of work, including the role of defender, supporter, case manager, resource mobilizer, trainer, consultant, evaluator and guidance. Interventions such as finding informational support, facilitating the patient hospitalization process, providing psychosocial support to the family with the aim of empowering them for post-transplant care, providing counseling to family members to deal with stress and improving mental health of the patient, providing economic support, Accomodation conditions are provided through hospital companions and communication and interaction with the treatment team, including the doctor, in order to respond to the needs of the family, facilitate treatment and on time discharging.
Conclusion: the protocol of specialized interventions of social workers in the transplantation process created a new step and a different look at psychosocial support in transplantation and coordination teams, so that social workers in the field of organ donation and transplantation and working with caregivers, families and the survivors of the patients arrived.
