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The relationship between platelet glycoprotein VI T13254C polymorphism and acute myocardial infarction (MI)
A Fatemi, A Kazemi, Mm Peighambari, N Givtaj, H Bakhshandeh,
Volume 5, Issue 2 (20 2011)
Abstract

Background and Aim: Myocardial infarction (MI) is a major cause of morbidity and mortality worldwide. Epidemiological studies indicate that MI results from complex interactions between long-term environmental influences, concomitant disorders, and genetic susceptibility factors. Identification of genetic risk factors, particularly in premature MI, is very important. Since thrombosis plays a critical role in the pathophysiology of MI, recent studies focus on coagulation genetic polymorphisms. The critical role of platelets and their surface glycoproteins in the formation of occlusive thrombus leading to acute myocardial infarction is now well accepted. Platelets have two major receptors for collagen, glycoprotein I/IIa (integrin α2β1) and glycoprotein VI. In the present study, platelet GP VI T13254C polymorphism was chosen due to its potential association with altered platelet reactivity. The aim of the present study was to determine whether or not GP VI T13254C polymorphism was associated with premature acute myocardial infarction.

Materials and Methods: One hundred patients with premature acute myocardial infarction and 100 age-matched controls with normal coronary angiograms were studied. Genotyping was done using PCR followed by RFLP. Statistical analyses included chi-square, t-test and logistic regression model.

Results: The findings of the present study showed that the prevalence of T13254C polymorphism did not differ much between patient (38%) and control (33%) groups and that polymorphism was not associated with premature acute MI (P=0.46). Logistic regression analysis also indicated no association between this polymorphism and premature acute MI (P=0.20).

Conclusion: This study showed that there was no significant association between GP VI T13254C polymorphism and premature acute MI.


The Current Situation and Estimation of Human Resources in the Field of Biology and Vector Control of Diseases in Iran
Mahboubeh Fatemi, Mohammad Reza Yaghoobi-Ershadi, Yavar Rassi, Mohammad Mehdi Sedaghat, Hassan Vatandoost, Mahboubeh Bayat, Mehrdad Zarabi, Fatemeh Nikpoor, Amir Ahmad Akhavan,
Volume 18, Issue 5 (11-2024)
Abstract
Background and Aim: Training and proper distribution of human resources are essential for maintaining and promoting society’s health. The first step in any health-related planning is to assess the current situation to draw a clear picture of the future to balance demand and supply. This research was conducted to assess the current situation of medical entomology and vector control/biology and vector control of the diseases in the country and determine the required human resources till 2025.
Materials and Methods: In this study, a “modified and combination model” was used, including the Hall model, which is location-based, and the Australian health workforce estimation model, which is a needs-based approach. The research was carried out in multiple stages, which included collecting the required data (number of faculty members, students, and graduates), the number of private companies providing spraying, and pest control services in all cities of the country and finally holding meetings with the board members of Biology and vector control of diseases and experts to estimate the human resources required in this field.
Results: Based on the data collected and face-to-face interviews conducted during six sessions with the experts in this field, it has been estimated that a total of 985 graduates have been trained in this discipline to date, while there is a requirement for 1,338 graduates in this area. Consequently, it is essential to train an additional 353 individuals in this field by the year 1404. In light of the country’s sixth five-year development plan, which allocates 30 percent of the total student population to postgraduate studies, it is imperative to prepare 35 individuals at the doctoral level, 71 at the master’s level, and 247 at the undergraduate level.
Conclusion: It seems that by accepting an average of 9 people at the Ph.D. level, 18 people at the master’s level, and 62 people at the bachelor’s level, in addition to matching the amount of demand and supply, there will be no problem for the employment of the graduates of this field.

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