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Preparation and Study of Nano-Niosomes Containing Doxorubicin and Evaluation of its Toxicity on Acute Myeloblastic Leukemia Cell Line KG-1
Fatemeh Bahrami-Banan, Mohammad Hasan Sheikhha, Nasrin Ghasemi, Mohammad Majdizadeh, Bibi Fatemeh Haghiralsadat,
Volume 12, Issue 4 (Oct & Nov 2018)
Abstract
Backgrounds and Aim: One of the effective strategies for targeting chemotherapy in the treatment of cancer is the use of lipid nano-carriers. In this study, an optimal formulation of niosomal drug containing doxorubicin has been developed to better fight cancer cells.
Material and Methods: Niosomal vesicles were prepared using phosphatidylcholine (22%), span60 (52/5%), cholesterol (22/5%) and DSPE-PEG2000 (5%) by thin-film method. Doxorubicin were loaded into the niosomes using inactive loading method. Their physico-chemical features were assayed using Zeta-Sizer, FTIR and SEM, and drug release amount was calculated at 37° C and 44° C. At the end, the toxicity of the nano drug carrier system was measured on the KG-1 cell line of the bone marrow cancer by MTT method.
Results: Niosomal vesicles containing Doxorubicin showed the size of 160.37±65.2 nm, 94.18% drug encapsulation efficiency  -58.11± 1.24 mV of zeta potential and polydispersity index (PDI) of 0.234±0.02 The prepared niosomal system presented drug controlled release and FTIR investigation showed almost no interaction between nano-carrier containing drug and the drug itself. As well, morphological examination of nano-carriers using SEM microscopy revealed that they have spherical structures. Also, cellular studies showed that drug toxicity was higher in encapsulated conditions compared to non-encapsulated conditions.
Conclusion:The results of this study, meanwhile confirming the proper physicochemical characteristics of the system and being Slow-release system indicate that this nano-carrier anionic increases the toxicity of the drug for the KG-1 cell line of the bone marrow, thus, this niosomal nano-carrier can be a suitable carrier for drug delivery to cancer cells.

The Effect of Eight Weeks of Aerobic Training on Serum Lipid Profile and Serum Level of Fibrinogen in Middle-Aged Men with Heart Failure
Malihe Shamsizadeh, Seyed Mahmood Hejazi, Shima Minaee, Hoda Haghir, Laaya Rajayi,
Volume 14, Issue 1 (Apr & May 2020)
Abstract
Backgrounds and Aim: Cardiovascular diseases, especially atherosclerosis, are among the main causes of mortality in developing countries of Asia and West Asia. The purpose of this study was to investigate the effect of eight weeks of aerobic training on serum lipid profile and fibrinogen in middle-aged men with heart failure.
Materials and Methods: Twenty men with aged 50 to 60 years, with heart failure grade 1 to 3, and heart power of less than 45% were selected and then randomly divided into experimental and control groups. Aerobic exercise was included of eight weeks of aerobic training with intensity of 35-65% of maximal heart rate with a three-session frequency per week. Fasting blood samples were collected from participants before and after of eight weeks. Data were analyzed by Paired sample t-test and Independent sample t-test.
Results: The results showed that after eight weeks of intervention, mean changes of HDL, TC / HDL ratio and fibrinogen were statistically significant (P<0.05). On the other hand, mean changes in LDL, TG, TC and LDL / HDL ratio were not significant (P>0.05).
Conclusion: The results of this study indicate that performing aerobic exercises along with drug therapy can be useful as a good way to prevent cardiovascular disease in people with heart failure

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