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Showing 3 results for Hassani

Mohammad Sabbaghi , Ahmad Kazemi , Saeed Hassani, Kamran Alimoghaddam, Ardeshir Ghavamzadeh, Seyed Hamidollah Ghaffari ,
Volume 8, Issue 4 (11-2014)
Abstract

Background and Aim: Acute promyelocytic leukemia (APL) is a distinct type of leukemia which is caused due to a blockage in myeloid cells normal maturation. The most important therapeutic strategies include the use of ATRA and Arsenic trioxide. Although ATRA is generally well tolerated, some patients develop Retinoic acid syndrome. Some of the symptoms of this syndrome are directly or indirectly related to elevated WBC counts. This study aims to determine the effect of ATRA and BIBR1532 combination on WBC count as a factor leading to the formation of ATRA syndrome.

Materials and Methods: To investigate the effect of BIBR1532 and ATRA combination, NB4 cells were cultured in the presence of 30μ M and 1 μM densities of the drugs. To study the effect of drugs on living cells count, proliferation activity, and metabolic activity of the cells, Trypan blue, Brdu and MTT tests were used, respectively.

Results: The results of Trypan blue, MTT and Brdu suggest that the combination of ATRA and BIBR1532 is more effective than ATRA alone on the reduction of viable cell count, metabolic activity and proliferation of leukemic cells in the first five days of treatment.

Conclusion: The results suggest that the combination of ATRA and BIBR1532 is probably more effective in the treatment of APL patients. It seems that such improvement in results is more obvious especially among the patients who are at a higher risk of ATRA syndrome. 


Hossein Hassani, Maryam Arab-Moorchegani, Narges Parsaie, Mahshid Rezaei, Khadijeh Mirzaei, Hossein Imani, Mir Saeed Yekaninejad,
Volume 16, Issue 2 (Jun 2022)
Abstract

Background and Aim: Currently, utilizing different nutritional indicators to investigate the association between diet and various diseases is considered in previous studies, which is related with some chronic diseases. However, no studies have studied the connection between the indicators with the rate of metabolism at rest (RMR). Therefore, the present study aimed to determine the relationship between dietary index and insulin load with resting metabolic rate (RMR) in overweight and obese women
Materials and Methods: A total of 280 healthy overweight and obese women (aged 18-50 years) who were referred to community health centers of Tehran University of medical sciences were included. In this study anthropometrics measurements such as weight, height, waist circumference, waist to hip ratio, body mass index, fat percentage, and fat-free mass were evaluated for every participant. Data on dietary intakes were collected using 147 semi-quantitative food frequency questionnaire (FFQ). DII and DIL were calculated using food insulin index values published earlier. To assess the RMR, indirect calorimetry was used. 
Results: Mean age of study participants was 36.4±8.38 years. Although a significant association was seen between DII and RMR in a crude model (P=0.04); adjusting for different confounders made this significant relationship between DII and RMR insignificant. In addition, the dietary insulin index had no significant relationship with the amount of RMR/kg (p=0.63) and RMR/FFM (p=0.73).
Conclusions: Based on the results of this cross-sectional study, it seems that the insulin index and insulin load of the diet are not associated to the rate of resting metabolism. However, due to the limitations of this study, findings can only confirm or reject the hypothesis under further studies. It is also necessary to determine the role of dietary insulin indicators on human health, especially with a Study Prospective Design

Samira Sadat Pourhosseini, Vahid Yazdi-Feyzabadi, Mohammad Hossein Mehrolhassani,
Volume 19, Issue 6 (3-2026)
Abstract

Background and Aim: Identifying and transferring lessons learned from past disasters can significantly improve future disaster management performance. Although the general principles of disaster management are similar across events such as earthquakes, context-specific factors, including geographical location, scale and severity of the event, timing, and local characteristics, can shape distinct challenges and, consequently, different management approaches. Therefore, conducting case-based studies that account for the unique conditions of each disaster is essential for effective learning. This study focuses on the Kuhbanan earthquake and aims to identify management challenges arising from the specific characteristics of this region.
Materials and Methods: This study employed a qualitative design using a directed content analysis approach. The study population consisted of experts, decision-makers, and frontline practitioners directly involved in managing the Kuhbanan earthquake. Using purposive sampling with maximum variation, 15 participants were selected from key organizations, including the University of Medical Sciences, the Iranian Red Crescent Society, the Provincial Crisis Management Center, and non-governmental organizations active in rescue and relief operations. Data were collected through in-depth semi-structured interviews, with questions developed based on the dimensions of the STEEPV framework (Social, Technological, Economic, Environmental, Political, and Values). Interviews continued until data saturation was achieved. Data analysis was conducted using MAXQDA software.
Results: Data analysis led to the identification of 42 initial codes, 14 subcategories, and six categories aligned with the STEEPV framework. In the social dimension, key challenges included deficiencies in public and professional training systems (3 codes), weak intersectoral communication and coordination (6 codes), and inadequate responsiveness to community health needs (4 codes). In the technological domain, major limitations were observed in information management (2 codes) and the capacity of technological infrastructure (2 codes). From an economic perspective, financial constraints (5 codes) and welfare-related barriers (3 codes) were identified as influential factors. In the environmental dimension, specific geographical and climatic conditions including mountain topography, fault proximity, and mining operations (4 codes), along with unsuitable physical spaces for disaster management (3 codes), posed major challenges. In the political sphere, a noticeable gap between the government and the public (2 codes) and weak performance of some executive institutions (2 codes) were evident. Cultural and values-related challenges included specific local beliefs (1 code), inappropriate behaviors among communities and relief teams (2 codes), and insufficient consideration of regional culture in rescue and relief operations (3 codes).
Conclusion: This study demonstrated that despite the relatively small scale of the Kuhbanan earthquake, many structural and managerial challenges previously observed in larger disasters were repeated. This finding highlights a chronic weakness in institutional learning and process improvement within the disaster management system. The application of comprehensive analytical frameworks such as STEEPV can assist managers and planners in understanding the complexity and interconnections of different crisis dimensions, moving beyond fragmented and reactive approaches toward more informed decision-making, enhanced stakeholder coordination, and ultimately greater community resilience. It is recommended that the findings of this study be used as a roadmap for revising national disaster management policies and for designing an integrated disaster lesson-learning system.


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