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The Effect Of -401CT And -401CT Polymorphisms Of GGH Gene On Methotrexate Serum Level And Toxicity In Iranian Children With Acute Lymphoblastic Leukemia (ALL) Under Treatment In Ali Asghar Hospital In Tehran
Abolfazl Kalantari , Farhad Zaker, Shahla Ansari Damavandi , Heydar Sharafi , Seyed Amir Yazdanparast ,
Volume 8, Issue 5 (1-2015)
Abstract

Background and Aim: Acute lymphoblastic leukemia patients show differences in serum levels and toxicity associated with methotrexate after its treatment. Pharmacogenetics is an important determining factor for these differences. In this study, the effect of +452 C / T and -401C / T polymorphisms of GGH gene on serum levels and toxicity associated with methotrexate was studied. The aim of this study was to evaluate the effect of +452C / T and -401C / T polymorphisms of GGH gene on methotrexate level in serum and its associated toxicity in patients with acute lymphoblastic leukemia. Furthermore, the frequency of the above polymorphisms was investigated for the first time in Iran.

Materials and Methods: The prevalence of these polymorphisms was assessed in 83 Iranian patients with ALL using PCR and RFLP. The relationship between the polymorphism and serum methotrexate levels and its toxicity was estimated by calculating the Odds Ratio.

Results: No correlation was found between +452CT polymorphism and serum levels of methotrexate and methotrexate-related toxicity. -401CT polymorphism was found to be correlated with methotrexate-related toxicity leading to thrombocytopenia (95% CI= 0.009-0.019, odds ratio=0.265) and leukopenia (95% CI = 0.021-0.042, odds ratio = 2.182) in consolidation phase of the treatment.

Conclusion: Evaluation of patients for methotrexate-related polymorphism of GGH gene may be useful in selecting the appropriate dose of methotrexate and reducing the toxic side effects associated with its administration.


Information Seeking Behavior of Postgraduate Students of Qazvin University of Medical Sciences for Retrieval of Specialized Images and Videos
Atefeh Kalantari, Abdolrasool Jowkar , Hassan Jahani Hashemi ,
Volume 11, Issue 4 (12-2017)
Abstract
Background and Aim: Technical videos and images are of great importance in learning different topics of medical sciences. This study is conducted to determine the effect of videos and images in learning from students’ point of view and also their problems in accessing them.
Materials and Methods: This is a survey study. Data were collected by a self-made questionnaire and the population included postgraduate students of Qazvin University of Medical Sciences in the first semester of 94-95.
Results: More than half of the students stated that images and videos have an average or more-than-average effect on their learning achievements. There is no significant relationship between students’ fields of study and their feeling the need for specialized images and videos. To get advice, they refer more to their professors or classmates than to librarians. A large number of responding students had not heard even the names of specialized image-and-video databases or they had never used them before. Low-speed internet and filtering of sites are the most important factors in students’ failure to access their required images and videos while students themselves have ranked ‘unfamiliarity with specialized databases’ as the fourth important factor.
Conclusion: The students know the importance of images and videos in learning achievements, but since they don’t know the professional databases and don’t have an appropriate interaction with librarians, they resort to general search-engines and, as a result, they face with blocked sites and are deprived from what they really want.

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