Parastoo Zakipour, Davoud Kianifard, Ghasem Akbari, Emad Khalilzadeh,
Volume 13, Issue 1 (Apr & May 2019)
Abstract
Background and Aim: Methylphenidate (MPH) is one of the commonly used drugs in the treatment of hyperactivity disorder in children. The use of MPH has been associated with increased activity of the central nervous system so may lead to the abuse of this compound. Nicotine is one of the compounds available in a wide range of people in various forms. The negative effects of nicotine on pituitary-testicular axis and spermatogenesis have been reported. In this study, the effects of long-term and simultaneous administration of methylphenidate and nicotine before and during pregnancy in mice on the microscopic structure of testicular tissue in newborn babies were evaluated.
Materials and Methods: Adult mice received nicotine and methylphenidate for eight weeks before and during pregnancy. Embryologic indices and microscopic structure of testicular tissue were evaluated in newborn babies.
Results: The results showed that embryologic and histologic indices in newborns from treated mice decreased in comparison to control group. A decrease of cellular population of seminiferous tubules and development of some structural changes in seminiferous tubules has been observed in treated groups.
Conclusion: The results of this study showed that the simultaneous administration of nicotine and methylphenidate before and during pregnancy could induce some structural alterations in testicular tissue in embryonic development and postnatal period.
Mostafa Roshanzadeh, Mina Shirvani, Ali Tajabadi, Mohammad Hossein Khalilzadeh, Somayeh Mohammadi,
Volume 16, Issue 2 (Jun 2022)
Abstract
Background and Aim: Clinical learning is an important part of the health field, where the student interacts with the environment and applies the learned concepts in practice. Clinical environments such as operating rooms are challenging for students due to their special complexity and can have a negative impact on their learning process. In order to identify students ‘learning challenges in the operating room environment, the present study was conducted to explain students’ experiences in the field of clinical learning challenges.
Materials and Methods: The present qualitative study was performed by contract content analysis method in 2022 in Shahrekord University of Medical Sciences. Fourteen surgical technology students were purposefully selected and data were collected using in-depth semi-structured individual and group interviews and analyzed using the Granheim and Landman approaches.
Results: The participants were interviewed over a period of 5 months. 9 face-to-face interviews were conducted with 14 participants. There were 6 individual interviews and 3 group interviews. The average duration of the interview was 30 minutes. The interviews continued until data saturation and when no new themes or categories were obtained from the interviews. The findings included a theme of “unfavorable learning environment” and three categories of “confusion in learning educational content, improper professional behavior of staff and insufficient self-confidence”. The main challenge that students faced in the field of clinical learning was the unfavorable learning environment. Conditions such as confusion in learning educational content, improper professional behavior of staff and insufficient self-confidence experienced by the students in the operating room, cause the students to find the learning atmosphere in the operating room unfavorable.
Conclusion: Improving the behavior and performance of staff and physicians in accordance with the standards of professional and ethical behavior and its regular evaluation from the perspective of students and other colleagues can play an effective role in maintaining professional conditions. Also, using experienced instructors who have the role of facilitating communication and learning of students in the operating room environment will play an effective role in reducing fear and controlling inappropriate behaviors of staff towards students. Educational officials are advised to solve the existing problems in order to improve the educational atmosphere of the operating room.
