Search published articles


Showing 3 results for Mahmodi
The effect of zoledronic acid on BSP expression and methylation during osteoblastic differentiation of mesenchymal stem cells
M Farsh Dusty Hagh, M Nowrozi Niya, Y Mortazavi, M Soleymani, S Kaviyany, M Mahmodi Niya Meymand,
Volume 5, Issue 1 (26 2011)
Abstract

Background and Aim: Bone sialoprotein (BSP) is a specific marker of osteoblastic differentiation. In this research, the effect of Zoledronic Acid on BSP expression and methylation status during osteoblastic differentiation of mesenchymal stem cells (MSCs) was evaluated.

Materials and Methods: In this experimental study, MSCs were isolated from human bone marrow. For osteogenic differentiation, hMSCs were pulse treated with zoledronic acid, and were incubated in osteogenic differentiation medium for 3 weeks. The DNA and RNA were extracted after the first, second and third weeks of culture and also from undifferentiated MSCs. After Sodium bisulfate (SBS) treatment, gene specific methylation analysis for BSP was carried out using Methylation Specific PCR technique.

Results: BSP expression was observed in osteoblastic differentiated cells whereas it was not seen in MSCs. MSP showed that BSP was unmethylated during osteoblastic differentiation.

Conclusion: BSP was expressed from the first week of differentiation. This confirms that zoledronic acid accelerates osteoblastic differentiation. Unmethylation status of BSP indicates that zoledronic acid does not have any effect on BSP methylation status. Other genetic or epigenetic mechanisms may control BSP expression during osteoblastic differentiation induction by zoledronic acid.


Comparison of Quality of Life Before and After Cosmetic Rhinoplasty among People Who Attended Plastic Surgery Clinics and Estimating Its' Cost in Tehran
Marita Mohammadshahi , Abolghasem Pourreza , Aboali Vedadhir , Parvaneh Heidari Orojlo, Mahmod Mahmodi, Feizallah Akbari,
Volume 10, Issue 3 (7-2016)
Abstract

Background and Aim: Cosmetic surgery rhinoplasty, has dramatically been increased during the last two decades. This study aims to explore its effects on the quality of life of individuals gone under the surgery.

Materials and Methods: This was a descriptive and analytical study which was performed as a cross-sectional study. From all plastic surgery clinics in Teheran, 25 clinics were selected randomly as the site of study. In the next step 110 patients undergone rhinoplasty were selected randomly from these clinics. Collected data was analyzed by Spss17.

Results: Findings revealed that, the mean score of quality of life before and after surgery was statistically significant. While mean score of general benefits increased the score of social support and physical health was decreased after the surgery. The most motivating factors for surgery were external factors. In addition there was a positive correlation between quality of life and the time of interview. Also the mean cost of surgery was increased.

Conclusion: Overall quality of life among study population was decreased. It could be because of unnecessary surgeries, medical errors, and etc. The reduction for social support may be resulted from unacceptable consequences of rhinoplasty particularly in terms of appearance. Physical health of respondents was negatively affected by rhinoplastiy surgery. Malfunctions of upper respiratory system after rhinoplastiy surgery is known as the main reason for it. Correlations between the times of surgery and interview suggest a long term assessment of impacts of such surgeries.


Psychological Empowerment and the Factors Affecting it on the Staff of Medical Sciences Universities of Tehran in 2018
Nayereh Sadat Roohollahi, Iravan Masoudi Asl, Somayeh Hessam, Mahmoud Mahmodi,
Volume 12, Issue 6 (Feb & Mar 2019)
Abstract
Background and Aim: With empowerment of employees, organizations can take very effective steps in the path to growth and development, which is possible through examining the factors affecting it. This study aimed to determine psychological empowerment and factors affecting it on the staff of medical sciences universities of Tehran.
Materials and Methods: This cross-sectional analytical descriptive study was conducted in 2018 among the personnel of selected medical sciences universities of Tehran (Tehran, Iran, and Islamic Azad University). The universities were randomly selected using cluster sampling, and sample members were chosen from each university in an accessible manner. The sample included 410 individuals. The research instrument was a researcher-made psychological empowerment questionnaire. Validity and reliability (α=0.89) of the questionnaire were confirmed. Data were analyzed by SPSS version 22, Chi-square test, and Pearson correlation coefficient. P<0.05 was considered as a significant level.
Results: Of the 410 subjects, 290 (70.7%) were female. The highest percentage (51.4%) of employees in all three universities had moderate ability. Pearson's correlation coefficient showed a direct and meaningful statistical relationship between employees' ability and the factors affecting it such as sense of competence, sense of meaningfulness, and sense of the right to choose (p<0.001). The highest correlation (r=0.654) was found between significant sensory factor and employees' ability (p<0.001).
Conclusion: The results showed that the psychological empowerment of staff in medical sciences universities is moderate. Also, there are many factors such as sense of meaningfulness, sense of being effective, sense of the right to choose, and sense of competence in their psychological empowerment.

Page 1 from 1     

© 2024 , Tehran University of Medical Sciences, CC BY-NC 4.0

Designed & Developed by: Yektaweb