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Investigating the Relationship between Factors Affecting Hip Fracture and Its Consequences in Imam Khomeini Hospital Complex during 2017-2020
Mahya Jafarnejad, Esmaeil Mohammadnejad, Leila Sayadi, Shima Haghani, Reza Ghanei Gheshlagh, Afzal Shamsi,
Volume 16, Issue 3 (Aug 2022)
Abstract
Background and Aim: Fractures and dislocations of the femur are a common and disruptive public health problem worldwide. One of the most common ways is to identify the factors associated with common outcomes that increase mortality, length of hospital stay, and postoperative complications. By identifying these factors, the adverse outcomes of elderly hip fractures can be prevented. Therefore, the aim of this study was to determine the relationship between factors affecting hip fracture and its consequences. 
Materials and Methods: The present study was a descriptive cross-sectional observational study. The study population in this study included patients with hip fractures. Patients’ information was examined between 2017-2020 years. Data were analyzed by SPSS applying descriptive statistics, Fisher Exact test, chi-square, independent t-tests, and analytical regression.
Results: The results showed that in this study, the majority of patients with hip fracture had an underlying disease (73.9%). The most common underlying diseases in patients included high blood pressure (20.7%), diabetes (13.2%) and heart diseases (10.5%). The most common causes of death was include old age (40.4%), prevalence of covid-19 (20.2%), heart attack (11.7%), pulmonary embolism (10.6%) and surgical wound infection (10.6%). The most common cause of hip fracture was osteoporosis (26.3%) and falling from a height (24.7%). Also level of education (P=0.0001), causes of fracture (P=0.001), type of anesthesia (P=0.001), history of hospitalization in special wards (P=0.001), readmission (P=0.0001), age (P=0.001) and level of self-care (P=0.001) were significantly associated with elderly mortality. There was a significant relation between type of surgery (P=0.038), history of hospitalization in intensive care units (P=0.001), history of blood transfusion (P=0.021) and level of self-care (P=0.001) with length of hospital stay of fractured elderly hip.
Conclusion: It can be concluded that by identifying the factors affecting the length of hospital stay, surgical wound infection and mortality of the patients with hip fractures, witness better surgery results, shorter hospital stay, less postoperative complications and reduced death. Some factors such as osteoporosis are preventable, which can be prevented with timely education.

Hematological Evaluation of the Interaction of Broncho T.D® and Isoproterenol in Experimental Study
Keivan Keramati, Sina Adib, Mahmood Ahmadi Hamedani, Leila Mohammadnejad Nasrabadi,
Volume 19, Issue 2 (7-2025)
Abstract
Background and Aim: BronchoT.D is an Iranian herbal drug manufactured for human consumption and has anti-cough and expectorant properties. Isoproterenol is a non selective agonist of beta-adrenergic receptors that although has been used as a drug in cases such as bradycardia, but based on the results of some studies, it has been determined that isoproterenol can also lead to tissue damage and hematological changes. The aim of this research was hematological evaluation of the interaction of BronchoT.D® with isoproterenol.
Materials and Methods: This was an experimental study. Eighteen male wistar rat were used in 3 experimental groups (each group 6 rats) including control, recipient of isoproterenol and normal saline and recipient of isoproterenol and BronchoT.D. There was no intervention in the control group. Isoproterenol was administered via twice injection and normal saline and BronchoT.D were administered five times orally. Finally, blood was collected from the rats and White Blood Cells (WBC), Red Blood Cells (RBC), Hematocrit (Hct), Hemoglobin (Hgb), Mean Corpuscular Volume (MCV), Mean Corpuscular Hemoglobin Concentration (MCHC) and Platelets (Plt) were measured. Statistical analysis of data was performed through one-way analysis of variance using SPSS software. 
Results: In terms of WBC, the difference between the experimental groups was not significant. The isoproterenol and normal saline receiving group had a significant increase in terms of RBC, Hct, Hgb and Plt as compared to the control group. The difference between the isoproterenol and BronchoT.D receiving group was not significant in terms of RBC, Hct and Plt as compared to the control group. In terms of Hgb and MCHC, the isoproterenol and BronchoT.D receiving group had a significant increase as compared to the control group. In term of MCV, the difference between experimental groups was not significant. The isoproterenol and normal saline receiving group did not differ significantly in comparison with the control group in term of MCHC. 
Conclusion: Based on the findings of this study, it can be concluded that BronchoT.D not only prevents some hematological changes caused by isoproterenol, such as an increasing of RBC and plt, but can also increase the oxygen-carrying capacity of blood through a significant increase in Hgb and MCHC. BronchoT.D probably causes such effects by counteracting oxidative stress or by directly affecting the bone marrow, although additional researches are necessary to investigate such probablities.

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