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Comparing The Effect Of Lactobacillus Aacidophilus And MRS Medium On Mesenchymal Stem Cells Proliferation
Mostafa Saberian , Elham Shahidi Delshad , Tahereh Naji , Ali Samadikuchaksaraei ,
Volume 9, Issue 3 (9-2015)
Abstract

Background and Aim: The use of probiotics has been surveyed in different studies. For example, many researches have been conducted on immunity, cancer and embryonic cells proliferation. Mesenchymal stem cells (MSCs) have a rather slower growth and a more limited number of passages. In this research, the effect of supernatant of Lactobacillus acidophilus (LS) as one of the most commonly used probiotics on the proliferation of mesenchymal stem cells has been studied with the aim of increasing their proliferation for the treatment of patients in need of transplantation using mesenchymal stem cells.

Materials and Methods: The MSCs separated from rats’ bone marrow were led to bone and fat levels in the second passage, and their mesenchymal state was confirmed. The cells were then treated by the supernatant of Lactobacillus acidophilus (LS) and MRS broth medium, which have been separated in advance. The number of cells was examined by MTT test equated with the standard.

Results: A curve was drawn for the cells’ growth in different amounts and the number of cells was obtained by converting the results of MTT test to a standard curve. For statistical analyses, SPSS and ANOVA were employed.

Conclusion: The findings show the double effect of LS on the weak effect of MRS broth medium. The use of supernatant of Lactobacillus acidophilus (LS) can be a practical and economical method for increasing the proliferation of MSCs isolated from bone marrow.


Expression Of CK19 Gene In Patients With Lung Cancer And Its Comparison With Carcinoembryonic Antigen In Peripheral Blood
Abdolreza Mohamadnia, Shirin Karimi, Reza Yadegar Azari , Seyed Alireza Naji, Adnan Khosravi, Naghmeh Bahrami, Massoud Saidijam,
Volume 9, Issue 5 (2-2016)
Abstract

Background and Aim: Lung cancer is the most common cancer among men around the world. The aim of this study was to determine the expression levels of CK19 mRNA marker in the affected patients’ peripheral blood.

Materials and Methods: Thirty patients with lung cancer (NSCLC type) were compared with 30 healthy controls. After taking peripheral blood samples and extracting total RNA, cDNA was synthesized and examined by Real-time RT-PCR technique. Then, the CEA antigen was measured by ELISA.

Results: The CK19mRNA was positive in 7 out of 30 lung cancer patients. Hence, its sensitivity was determined to be 23.3 %. The serum level of CEA antigen was positive in 11 out of 30 lung cancer patients. The mean serum level of CEA antigen markers was higher in patients than in controls; the difference was statistically significant (P< 0.001). The sensitivity of this test was determined to be 36.6 %.

Conclusion: This study showed that the sensitivity of CK19 mRNA in peripheral blood was low, but it had a high specificity for the diagnosis of primary lung cancer. Also, it was found that CEA antigen could be the specific marker for the early detection of lung cancer in patients’ peripheral blood.


A Bibliometric and Altmetrics Analysis of Highly Cited Articles in the Field of Infectious Diseases
Najibeh Shenavar, Hashem Atapour, Ameneh Shenavar,
Volume 15, Issue 5 (Dec 2021 & Jan 2022)
Abstract
Background and Aim: Infectious Diseases are among the diseases involved in public health and a high percentage of causes of death worldwide are attributed to these diseases. The purpose of this study was to investigate the status of highly cited articles in the field of infectious diseases based on bibliometrics and Altmetrics indicators.
Materials and Methods: This descriptive-analytical research was applied research that has been done using bibliometrics and Altmetrics methods. The research population included 687 highly cited articles indexed on the Web of Science (WOS) database between 2010-2020. Web of Science database and Bookmarklet tool was used for data collection and VOSviewer, Excel, and SPSS software were used for data analysis.
Results: The production process of highly cited articles have had an upward trend. The highest publication rate was in 2020 and the lowest in 2010. The United States published the largest number of articles with 49%, and Lisa Maragakis and Deborah Yokoe were among the most prolific writers. The Lancet Infectious Diseases Magazine and the Center Disease Control Prevention Institute have contributed the most to the publication of articles citing infectious diseases. Vocabulary: COVID 19, epidemiology, disease, mortality, and infection were the most widely used terms in the field of infectious diseases. Mendeley and Twitter were also among the most important social media sites that cited highly cited articles.
Conclusion: The results showed that there is a significant relationship between Altmetrics indices and the number of citations. Also, by identifying the characteristics of highly cited articles in the field of infectious diseases, an attempt has been made to provide a clear view of the top authors, countries, institutions, and journals, and of course, researchers can use the hot and emerging topics identified in this research in future research.

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