Journal of

Background and Aim: In several KT plans the researcher self evaluation is basis of researchers KT activities measurement so the aim of this study was the validity of researchers self assessment about their own activities in KT.

Materials and Methods: The valid and reliable questionnaire was filled by 40 Golestan University of Medical Sciences researchers. In this questionnaire researchers were asked to give a score from 0 to 10 for their own activities in KT in a finished special project. Statistical analysis was performed using pair T test and Pearson correlation coefficient. The linear regression was used for assessing the effect of influential factors on KT self evaluation and activity scores.

Results: The mean score of researchers KT activity and self evaluation was 3.52 and 5.47 respectively which this difference was statistically significant (P<0.01). The correlation coefficient between researchers' activity and self evaluation score was 0.73 which is an indicator of good correlation. The influential factors on researchers' KT self evaluation score in regression model was male gender, having administrative responsibility and percent of total time allocated to research and the influential factors on researchers' KT activities score in regression model was male gender, type of research (clinical sciences research compared to basic sciences) and percent of total time allocated to research.

Conclusion : The results of this study shows that researchers overestimate their own activities in KT so adopting strategies like education about KT concepts and activities for increasing researchers knowledge and perception can fill research and action gap.

Background and Aim: Breast cancer is epidemiological and most important cause of death in women. Oxidative stress plays an important role in this disease. Antioxidants such as some vitamins has attracted the attention of scientists to deal with oxidative stress. The aim of this study was to determine the effect of vitamin supplements in reducing oxidative stress in breast cancer.

Materials and Methods: 38 BALB-C mice were used. They were created in the breast cancer by cell implantation procedure. Rats were divided into 4 groups: 4 mice were given vitamin supplements for 1 month, 4 mice vitamin A, 4 mice, vitamin D, and 4 mice were given vitamin E respectively. After a month mice had breast cancer. In the second group mice without vitamin supplements, were affected. In the third group, mice with vitamin supplements were not affected. In the blood serum of rats, the catalase, superoxide dismutase and total antioxidant capacity was measured by ELISA.

Results: Catalase activity in mice that received vitamin supplements was significantly increased and were diagnosed (P=0.049). But the increase was not significant with vitamin D supplement (P=0.287). Superoxide dismutase in mice that received vitamin supplements and were free of disease increased significantly (P=0.0249). But the increase was not statistically significant with vitamin D supplement (P=0.24).The total antioxidant capacity in mice that received vitamin supplements and were affected with breast cancer was significantly increased (P<0.0001). This increase was not significant with vitamin D (P=0.006).

Conclusion: The use of vitamin supplements with catalase, superoxide dismutase and total antioxidant capacity was significantly correlated and may increase the level of antioxidant markers.