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PPAR-γ Gene Expression In Differentiated Adipocytes Derived From Mesenchymal Stem Cells Of Human Bone Marrow
Shadi Esmaeili, Saeid Kaviani , Mehrdad Norouzinia, Amir Atashi , Masoud Soleimani, Saeid Abroun, Seied Rasoul Razavi Babaheidari , Zahra Zonoubi, Fakhreddin Saba,
Volume 8, Issue 6 (3-2015)
Abstract

Background and Aim: Obesity is now considered as one of the main risk factors of certain known diseases such as cardio-vascular diseases, non- insulin-dependent diabetes, and common cancers. Moreover, the increase of white fat tissue is known as a main factor in the obesity process, in terms of physiology and pathology. Therefore, the understanding of adipocytes differentiation processes is crucial.

Materials and Methods: In this study, mesenchymal stem cells (MSCs) were isolated from human bone marrow by ficol-gradient, and then, their surface markers were confirmed by flow cytometry. Osteoblastic and adipocytes differentiation were done by dexamethasone protocol and confirmed by staining. Then qualitative and quantitative expressions of PPARgamma (PPAR-γ) gene as an important transcription factor in the differentiation of fat were studied by RT-PCR and REAL TIME PCR before and after differentiation into adipocytes. For statistical analysis, paired t-test was performed, using pfaffl and graph pad software.

Results: PPAR-gamma gene expression showed a significant increase after differentiation of human bone marrow mesenchymal stem cells into adipocytes (p<0/05).

Conclusion: According to the results, the PPAR-γ gene acts as one of the important factors in the differentiation of MSCs into adipocytes. In brief, the inhibition of this gene's expression to prevent obesity is suggested as an idea for treatment in the future.


Evaluation of Oxidative Stress and DNA Damage Indicators Following A Long Period of Resistance Training in Sedentary Older Men
Javad Norouzi, Afsaneh Khosravi, Babak Hooshmand Moghadam, Abbas Ali Gaeini,
Volume 15, Issue 1 (Apr & May 2021)
Abstract
Background and Aim: Excessive production of free radicals and the accumulation of oxidative damages play an important role in accelerating the aging process. However, one of the ways to fight against aging and related diseases is through physical activity. The aim of the present study was to investigate the effect of 12 weeks of resistance training on oxidative stress indicators (8-iso-prostaglandin-F2α: 8-iso PGF2α) and oxidative DNA damage (8-hydroxydeoxyguanosine: 8-OHdG) in elderly men.
Materials and Methods: In this quasi-experimental study, 30 elderly men were selected voluntarily and purposefully as a statistical sample and were randomly divided into experimental (n=15) and control (n=15) groups. Participants of the experimental group performed resistance exercises three sessions per week for 12 weeks. At the beginning and end of the study, serum levels of 8-iso PGF2α and 8-OHdG were measured by ELISA method. Correlated and independent t-tests were used to compare intragroup and intergroup means, respectively.
Results: Serum values of 8-iso PGF2α (P=0.007) and 8-OHdG (P=0.013) decreased significantly after 12 weeks of resistance training. Also, there was a significant difference between the experimental and control groups in serum values of 8-iso PGF2α (P=0.009) and 8-OHdG (P=0.02).
Conclusion: It seems that 12 weeks of resistance training reduces the values of oxidative stress (8-iso PGF2α) and oxidative DNA damage (8-OHdG) indicators in older men. Therefore, regular resistance training can play an important role in preventing injuries caused by oxidative stress, especially in old age.

Assessment of the Quality of Smartphone-Based Applications and Games for Teaching Medical Terminology Using the Mobile Application Rating Scale (MARS)
Seyyedeh Fatemeh Mousavi Baigi, Reyhaneh Norouzi Aval, Masoumeh Sarbaz, Khalil Kimiafar,
Volume 18, Issue 4 (10-2024)
Abstract
Background and Aim: Proficiency in medical terminology is a basic competency of most medical students, which ensures communication with other healthcare providers. Facing the lack of motivation and involvement of students, applications, and games based on smartphones are considered as a possible educational option. Due to the rapid expansion of these applications, a correct evaluation of their quality is often not provided. This study investigated and evaluated the quality of smartphone applications and games for teaching medical terminology.
Materials and Methods: A systematic review was conducted in August 2024, in the official stores of Bazaar and Google Play applications. The two main keywords “medical terminology” and “medical vocabulary” were searched in Persian and English. Two evaluators independently downloaded and evaluated smartphone-based applications and games for teaching medical terminology. The same checklist was used for data extraction. The quality of apps was measured using the Mobile App Rating Scale (MARS). The points of each section, the final score of the retrieved applications, and the mean and standard deviation were obtained.
Results: In total, eighteen programs were included in this study, four of which were games. The average quality of the programs was between 2.70 and 4.30 (average 3.80) on a scale from 1 (inadequate) to 5 (excellent). The best scores are in performance (mean: 3.91), followed by information quality (mean: 3.15). Aesthetics (mean: 2.56) and mental quality of the program (mean: 2.58) had the lowest scores. Two applications offered data privacy, and four had privacy statements. The game ‘Dean Vaughn’ and the application ‘MediTerm’ received the highest overall scores.
Conclusion: This study provides an analysis and description of smartphone-based applications and games for teaching medical terminology to help students and users choose high-quality applications that suit their needs and tastes, and on the other hand, it provides the possibility of identifying research and operational gaps to strengthen and design more effective and better applications for the developers of these applications. The applications evaluated were generally of good overall quality, particularly in terms of functionality and information. However, some applications need to improve aspects such as aesthetics and subjective quality to increase their impact on users and ensure better security and privacy.

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