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Effect Of HESA-A On Acute Promyelocytic Cell Line(NB4) 
Soodeh Namjoo, Fatemeh Nadali, Ahmad Kazemi, Hossein Dargahi, Hossein Rezaiezadeh, Shahrbanoo Rostami, Seyed Nasser Ostad,
Volume 6, Issue 3 (7 2012)
Abstract

Background and Aim: Acute leukemia is one of the main causes of cancer in the world. Now a days using natural materials as source of anticancer drugs is more recommended. HESA-A is a drug of herbal-marine origin (patented by Iranian researcher). HESA-A is composed of 50% inorganic substance، 45% organic substance (aminoenthraquinone) and 5% water. In this study effects of HESA-A، on NB4 cell line (Acute promyelocytic leukemia cells) was evaluated.

Materials and Methods: HESA-A was prepared in normal saline as a stock solution (80 mg/ml, PH=7.4), and then was sterilized. After culturing and proliferation of NB4 cell line, the cells were treated by doses of 1, 2, 4 and 8 mg/ml of HESA-A. Respectively after 72h, the percentage of viable and dead cells were counted by using Trypan blue staining in Neubanr hemocytometer. Then by MTTassay, the percentage of cell survival were determined by ELISA reader in 570nm. Finally the effects of HESA-A on apoptosis were evaluated by flocytometery.

Results: This invitro study shows that HESA-A has a cytotoxcic and antiprolifrative effects against NB4 cell line (Dose dependent).IC50 dose was 5mg/ml .HESA-A can result in apoptosis in 50% of the cells.

Conclusion: Although the mechanism of HESA-A cytotoxicity action is not known, yet this study shows that this drug may cause apoptosis of cells by dose dependent method.


The Effect of Information Technology (IT) in the Empowerment of Staff in Tehran University of Medical Sciences
Saied Ghaffari , Sholeh Zakiani , Zohreh Rezaie ,
Volume 11, Issue 6 (3-2018)
Abstract
Background and Aim: In each organization, there is a debate about the use of IT. Human development is one of the factors influencing the efficiency and success of any organization. The present study aimed to investigate the effects of information technology on empowerment of staff working in Tehran University of Medical Sciences.
Materials and Methods: This study was descriptive-survey research and applied in terms of purpose. A total of 274 staff members from the Tehran University of Medical Sciences were surveyed by sampling according to the Krejcie-Morgan table from among 950 employees. The tools used in the Ardalan questionnaire were divided into two parts of IT, including 10 questions and a staff empowerment questionnaire containing 23 questions. Data were analyzed by SPSS 13 software, Kolmogorov-Smirnov test and one-sample T-test.
Results: The research findings showed that the use of information technology on five dimensions of job empowerment including competency, improvement of quality of work, increased decision-making power, increasing self-control, and reducing job stress have a significant effect.
Conclusion: The most important task of managers of universities is to improve the ability and job satisfaction of employees, holding in-service training courses in the field of computers and the Internet and encouraging employees to use more computers in their related activities.

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