M Farsh Dusty Hagh, M Nowrozi Niya, Y Mortazavi, M Soleymani, S Kaviyany, M Mahmodi Niya Meymand,
Volume 5, Issue 1 (26 2011)
Abstract
Background and Aim: Bone sialoprotein (BSP) is a specific marker of osteoblastic differentiation. In this research, the effect of Zoledronic Acid on BSP expression and methylation status during osteoblastic differentiation of mesenchymal stem cells (MSCs) was evaluated.
Materials and Methods: In this experimental study, MSCs were isolated from human bone marrow. For osteogenic differentiation, hMSCs were pulse treated with zoledronic acid, and were incubated in osteogenic differentiation medium for 3 weeks. The DNA and RNA were extracted after the first, second and third weeks of culture and also from undifferentiated MSCs. After Sodium bisulfate (SBS) treatment, gene specific methylation analysis for BSP was carried out using Methylation Specific PCR technique.
Results: BSP expression was observed in osteoblastic differentiated cells whereas it was not seen in MSCs. MSP showed that BSP was unmethylated during osteoblastic differentiation.
Conclusion: BSP was expressed from the first week of differentiation. This confirms that zoledronic acid accelerates osteoblastic differentiation. Unmethylation status of BSP indicates that zoledronic acid does not have any effect on BSP methylation status. Other genetic or epigenetic mechanisms may control BSP expression during osteoblastic differentiation induction by zoledronic acid.
Zahra Jalali, Hasan Ashrafi-Rizi, Mohammad Reza Soleymani, Mina Afshar,
Volume 11, Issue 4 (12-2017)
Abstract
Background and Aim: Functions and services of academic libraries have been affected very much by the entrance and the development of information technology (IT) in university libraries. Since the main mission of academic libraries is advance of educational and research programs of university, the authorities should deploy expertise with technical skills to be able to fulfill their most important job. The aim of this study was to identify factors influencing the adoption of information technology by librarians of governmental academic libraries based on the Technology Acceptance Model (TAM).
Materials and Methods: This was a survey research and the tool was a questionnaire based on TAM. The study population consisted of 151 librarians and census method was used. The validity was confirmed by experts in library and information sciences and also IT. Reliability obtained 0.89 using Cronbach's alpha. Statistical method was descriptive, inferential and data analysis was done via software SPSS20.
Results: Determination coefficient 0.282 shows that TAM is applicable in research population. This means that the applicability of the TAM was relatively appropriate for study about librarians of university libraries. Priorities effects of TAMs variables on the actual use of IT shows the most effective variable are intent to use (0.39), perceived ease of use (0.21), perceived usefulness (0.15) and attitude to use of IT (0.12).
Conclusion: Provision of required IT infrastructure and training for effective use should be considered for librarians. In addition to that, courses of introduction to library information technology should be included in the library and information science curriculum.
Azra Daei, Mohammad Reza Soleymani, Hasan Ashrafi-Rizi,
Volume 17, Issue 6 (2-2024)
Abstract
Background and Aim: The role of information in improving the health of society and reducing healthcare costs is undeniable. However, in practice, there exists insufficient and incomplete information among healthcare providers. This lack of comprehensive information among market players leads to inefficiencies and failure in market performance. The main goal of the current research was to investigate health information asymmetry and inadequacy within the health information market.
Materials and Methods: This article is a narrative and unsystematic review. Studies were retrieved from the Scopus, PubMed, Web of Knowledge, Magiran, Sid and Google Scholar databases by using the keywords of information inadequacy, Asymmetry of health information done in the fields of article title, abstract and keywords. Subsequently, according to the purpose of the study, the researchers selected relevant resources and summarized their findings.
Results: 18 paper were selected for this research. In this research, we specifically address health information inadequacies across three key sections: patients, doctors, and insurance. At the end of each section, ways to solve these deficiencies were mentioned. Results Showed patients faced with the phenomenon of injustice in accessing health information, and the continuation of this injustice leads to the poverty of health information, and due to the lack of proper access to health information, the asymmetry of information between the doctor and the patient was created. Doctors, on the other hand, faced challenges in accessing up-to-date and evidence-based information for patient care. Asymmetric information could be exploited, resulting in induced demand. Insurances face the problems of inappropriate selection, moral hazard and demand induction by the supplier or consumer.
Conclusion: Information asymmetry has seriously penetrated the health field and there is a high level of unconfident and uncertainty in it. One of the ways to overcome the health information asymmetry and insufficiency of the health information market is the access of all stakeholders to the information.
