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Parastoo Zakipour, Davoud Kianifard, Ghasem Akbari, Emad Khalilzadeh,
Volume 13, Issue 1 (Apr & May 2019)
Abstract

Background and Aim: Methylphenidate (MPH) is one of the commonly used drugs in the treatment of hyperactivity disorder in children. The use of MPH has been associated with increased activity of the central nervous system so may lead to the abuse of this compound. Nicotine is one of the compounds available in a wide range of people in various forms. The negative effects of nicotine on pituitary-testicular axis and spermatogenesis have been reported. In this study, the effects of long-term and simultaneous administration of methylphenidate and nicotine before and during pregnancy in mice on the microscopic structure of testicular tissue in newborn babies were evaluated.
Materials and Methods: Adult mice received nicotine and methylphenidate for eight weeks before and during pregnancy. Embryologic indices and microscopic structure of testicular tissue were evaluated in newborn babies.
Results: The results showed that embryologic and histologic indices in newborns from treated mice decreased in comparison to control group. A decrease of cellular population of seminiferous tubules and development of some structural changes in seminiferous tubules has been observed in treated groups.
Conclusion: The results of this study showed that the simultaneous administration of nicotine and methylphenidate before and during pregnancy could induce some structural alterations in testicular tissue in embryonic development and postnatal period.

Shahpar Zakipour, Behzad Farrokh Sersht, Mohammad Javad Taghipourian, Hasan Ali Aghajani,
Volume 14, Issue 3 (Aug & Sep 2020)
Abstract

Background and Aim: In recent decades, increasing productivity and reducing losses by improving abnormal behaviors in the workplace have attracted the attention of organizational behavior experts, especially health researchers. The purpose of the present research is to study the factors influencing the reduction of abnormal behaviors in health workplace.
Materials and Methods: By using meta-synthesis technique, the findings of the related internal and external studies were systematically analyzed using Sandelowski and Barroso seven-step method. The identified codes were classified, analyzed and interpreted by MAXQDA10. Kappa method and SPSS were used to measure reliability and quality control. The calculated kappa coefficient was 0.893, which indicated a good consistency.
Results: From 435 articles investigated in this field, 46 articles were selected, based on which 68 factors were identified. These factors were classified into 3 main categories and 11 pivotal codes. The influential factors identified in this study include individual factors(psychological, demographic, religious, and contextual), group factors(communication, appropriate reward system, and deterrent behaviors) and organizational factors(organizational space, organizational measures, organizational emotions, and job position perception).
Conclusion: The results of this study show that individual factors are the most important ones affecting the reduction of abnormal behaviors. Therefore, the findings of this study emphasize psychological, demographic, religious, and contextual factors in planning and managers’ interventions to increase productivity in health workplace.


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