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Hojjat Rahmani, Sadegh Moradi, Nayeb Fadaei Dehcheshmeh,
Volume 18, Issue 4 (10-2024)
Abstract

Background and Aim: The fundamental right and most valuable asset for all strata of society is the enjoyment of health. Individuals residing in nomadic settings face geographical, social, cultural, and linguistic barriers when seeking access to essential services. The provision of healthcare services to nomads has become a complex issue due to the nature of the lifestyle. The aim of this study was to assess the challenges in the provision of healthcare services among the nomads in the Khuzestan province.
Materials and Methods: This study uses a qualitative approach, involving seventeen managers and staff from health centers affiliated with Ahvaz University of Medical Sciences. The data collection approach was inductive. Data were gathered through individual interviews, and participants’ opinions were recorded. The data were analyzed using the conventional content analysis method with a mixed approach (deductive and inductive). The credibility and quality of the data were assessed using the Guba and Lincoln method.
Results: The challenges in providing healthcare services in nomads were identified in nine categories and three overarching themes. The themes encompassed the nature and characteristics of the non-sedentary populations, the healthcare system, and the responsibilities of other sectors. The nature and characteristics of the nomads were categorized into five categories: demographic, cultural, climatic-geographic, socio-ethnic-tribal, and lifestyle. The healthcare delivery comprises of two aspects: structural and procedural. Additionally, the duties of other development sectors were categorized into two categories: infrastructures and inter-sectoral collaborations. The results showed that nomads face barriers to receiving healthcare due to the inherent characteristics of them, the healthcare system, and the performance of other organizations. The unstable population, cultural diversity, scattered distribution of the population, and their ethnic and migration-based lifestyle are among the inherent characteristics of nomads that impact the provision of services.
Conclusion: The provision of health services to nomads is influenced by recipients’ and providers’ characteristics. Decision-makers and managers, considering the unique conditions of life in the design and implementation of health programs, decision-makers and managers should prioritize strengthening healthcare networks in hard-to-reach areas. Given the limited resources and infrastructure weaknesses in settlements, inter-sectoral collaboration and the development of resources and infrastructure (applying the One Health approach) are important.

Saeed Pirmoradi,
Volume 18, Issue 5 (11-2024)
Abstract

Background and Aim: One of the ways to control high blood pressure is to deactivate the renin-angiotensinogen-aldosterone RAAS system. Renin, also known as angiotensinogenase,It is a type of enzyme that is produced in the afferent arterioles of the kidney by special cells called juxtaglomerular cells and secreted into the bloodstream and converts angiotensinogen protein into angiotensin type 1, which is very effective in causing high blood pressure. Inhibition of renin as the rate-limiting step of this cycle is an effective way to stop it, which plays a role in the treatment of some diseases related to the heart and blood vessels and blood pressure. The purpose of this study is to use new and different methods based on software to discover newer medicinal compounds with less side effects and cost and in a shorter time to discover based on a reference drug for the treatment and control of blood pressure disease.
Materials and Methods: By selecting the inhibitory reference compound of renin enzyme by bioinformatics tools such as PHARMIT, ZINCPHARMER during virtual search through the structural and pharmacophoretic properties of the reference inhibitory compound, a number of new ligands were obtained. Then the docking process was performed and the selected top ligands in terms of toxicity, allergy, toxicity and ADME prediction were examined with the help of tools such as molsoft, PKCSM, way2drug and swiss ADME.
Results: Among the four final top ligands obtained, one of the ligands had the most interaction with different residues and with a higher docking binding energy (vina score=-9.7) than the others, and then the other two ligands had a favorable binding energy.Among the effective interacting residues, Asp215, Asp32 and Leu114 were bound to renin enzyme in superior ligands, such as the reference compound.
Conclusion: In general, the selected inhibitory ligands showed a good ability to interact with residues involved in substrate selectivity and catalytic activity and inhibition of renin enzyme activity according to the analysis of bioinformatics tools and their confirmation requires clinical studies.


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