Journal of

 Background and Aim: Due to certain problems including being away from their families, entering a large and full-of-tension environment, and having economic problems caused by lack of sufficient income, students are likely to lose their mental health. This study is aimed to investigate college students' conditions and lifestyle at Tehran University of Medical Sciences (TUMS).

 Materials and Methods: In this cross-sectional study, 120 students from School of Allied Medicine were selected through simple sampling. Data collection tools included demographic questions and a lifestyle questionnaire. After collecting the questionnaires and coding the questions, the obtained data were analyzed through such statistical tests as t-test and ANOVA using SPSS software version 18.

 Results: Students' scores on lifestyle test were in the intermediate range and far from a desired situation. A two-sample t-tests did not show a significant relationship between students' lifestyle and their gender and marital status (P>0.05). Moreover, ANOVA test didn't show a significant relationship between students' age and educational level on the one hand and their lifestyle factor on the other.

 Conclusion: The results of the study revealed that students' lifestyle scores were in the intermediate range and that the situation was far from good. Standard educational programs and interventions should be designed to change students' lifestyle. Nutritional and physical support systems and educational, cultural, and entertainment programs in the department of physical education can minimize the concerns and preoccupations of the studied population group.

Background and Aim: Obesity is now considered as one of the main risk factors of certain known diseases such as cardio-vascular diseases, non- insulin-dependent diabetes, and common cancers. Moreover, the increase of white fat tissue is known as a main factor in the obesity process, in terms of physiology and pathology. Therefore, the understanding of adipocytes differentiation processes is crucial.

Materials and Methods: In this study, mesenchymal stem cells (MSCs) were isolated from human bone marrow by ficol-gradient, and then, their surface markers were confirmed by flow cytometry. Osteoblastic and adipocytes differentiation were done by dexamethasone protocol and confirmed by staining. Then qualitative and quantitative expressions of PPARgamma (PPAR-γ) gene as an important transcription factor in the differentiation of fat were studied by RT-PCR and REAL TIME PCR before and after differentiation into adipocytes. For statistical analysis, paired t-test was performed, using pfaffl and graph pad software.

Results: PPAR-gamma gene expression showed a significant increase after differentiation of human bone marrow mesenchymal stem cells into adipocytes (p<0/05).

Conclusion: According to the results, the PPAR-γ gene acts as one of the important factors in the differentiation of MSCs into adipocytes. In brief, the inhibition of this gene's expression to prevent obesity is suggested as an idea for treatment in the future.

Background and Aim: One of the perennial questions for hospitals and insurance organizations are the real cost of g lobal surgery. The aim of this study was to compare the cost of global surgery bills with approved tariffs in hospitals affiliated to Tehran University of Medical Sciences Medical Sciences .

Materials and Methods: This was a cross – sectional study . The study population included all hospitalized patient bills eligible for global tariff at nine selected hospitals (include: Imam Khomeini, Shariati, Arash, Fatemeh Alzahra, Zanan, Cancer Institute and Razi) affiliated to Tehran University of Medical Sciences in 2012. Checklist was used for data collection. Data about the real costs of surgical procedures were collected from the patients' bills . Data were analyzed using descriptive statistics in SPSS version 16 software .

Results: The results showed that a total of 90 included global tariff surgical, 68 surgical procedures were performed in nine selected hospitals. Except seven surgical procedures in other cases (61 cases), the real costs of surgical procedures average 3 -312 percent more than approved global tariff. The surgical procedure "Septoplasty" had the most difference with global tariff.

Conclusion: The results showed that surgical global tariff are not real, and lead to the hospitals financial loss. Therefore, it is recommended that to prevent the hospital financial loss in the calculation of the g lobal t ariff factors such as patient age , presence or absence of comorbidity and complication, disease severity, length of stay and inflation rates in country to be considered .

Background and Aim: The use of probiotics has been surveyed in different studies. For example, many researches have been conducted on immunity, cancer and embryonic cells proliferation. Mesenchymal stem cells (MSCs) have a rather slower growth and a more limited number of passages. In this research, the effect of supernatant of Lactobacillus acidophilus (LS) as one of the most commonly used probiotics on the proliferation of mesenchymal stem cells has been studied with the aim of increasing their proliferation for the treatment of patients in need of transplantation using mesenchymal stem cells.

Materials and Methods: The MSCs separated from rats’ bone marrow were led to bone and fat levels in the second passage, and their mesenchymal state was confirmed. The cells were then treated by the supernatant of Lactobacillus acidophilus (LS) and MRS broth medium, which have been separated in advance. The number of cells was examined by MTT test equated with the standard.

Results: A curve was drawn for the cells’ growth in different amounts and the number of cells was obtained by converting the results of MTT test to a standard curve. For statistical analyses, SPSS and ANOVA were employed.

Conclusion: The findings show the double effect of LS on the weak effect of MRS broth medium. The use of supernatant of Lactobacillus acidophilus (LS) can be a practical and economical method for increasing the proliferation of MSCs isolated from bone marrow.

Background and Aim: Different regulation processes have an effect on osteoblastic differentiation of mesenchymal stem cells (MSCs), and among them Wnt signaling pathway is particularly desirable. In Wnt signaling pathway, Adenomatous Polyposis Coli (APC) bind to β-catenin and induce its degradation, thereby acting as a negative regulator of canonical Wnt pathway. In this study, gene expression and DNA methylation of APC gene during osteoblastic differentiation were determined.

Materials and Methods: In this experimental study, after the isolation of MSCs, the induction of osteoblastic differentiation was done. To confirm osteoblastic differentiation, alizarin red staining together with the expression of Alkaline Phosphatase (ALP) and osteocalcin as specific osteoblastic markers was performed. APC gene methylation status by MSP (Methylation Specific PCR) and gene expression status of APC gene using Real-Time PCR technique during different times were evaluated.

Results: The results of alizarin red staining and the expression of ALP and osteocalcin confirmed osteoblastic differentiation. In addition, the results showed a significant decrease in the expression of APC gene on the 7^th day of osteoblastic differentiation (P<0.05). Also, the results revealed hypermethylation status of APC gene promoter during osteoblastic differentiation.

Conclusion: It seems that the decreased expression APC gene will play an important role in Wnt signaling pathway regulation in different stages during osteoblastic differentiation of bone marrow-derived MSC. Also, according to the results, APC gene promoter methylation will play an important role in controlling gene expression.

Background and Aim: With regard to the effect of environmental health for employees, and with regard to the lack of a proper plan for identifying and controlling harmful occupational factors, it is necessary to create workplace health identification cards. The aim of this research is to design an identification card, which includes all the information about the workplace health of the employees of administrative section of a ministry, which could be updated in specific time intervals.

Materials and Methods: The present research was an applied, descriptive and  observational study which was conducted in 2015 in 100 work stations which were randomly selected in a governmental ministry through designing of two forms, including the information about workplace building, and the health information of the work station. The employees were also interviewed in order to collect data about each workstation regarding the machines for measuring the light, sound, temperature, ventilation, and rays. The opinions of four experts in the fields of environmental health, public health, occupational health, and civil health was used to analyze the data.

Results: A workplace health identification card was designed and determined through using the data obtained in this research. The following issues from this identification card, including standardizing the workplace of administrative employees, creating a data bank from the information, related to workplace health.

Conclusion: Workplace health identification card will be created and the standard management procedure will be designed for the purpose of health inspections of the workplace of administrative employees through the data extracted from this research.

Background and Aim: Evaluating and improving the employees’ quality of work life is one of the most important responsibilities of managers in each organization. The aim of this study was to design and prepare a questionnaire for evaluating the residents’ quality of work life and checking the validity and reliability of this tool.
Materials and Methods: We collected the questionnaires which were used for the employees’ quality of work life, and designed by Delphi method a comprehensive questionnaire for measuring residents’ quality of work life. This questionnaire was distributed two times with one-week interval between 14 residents of Tehran University of Medical Sciences and then the validity and reliability was assessed by α cronbach model. We used the 5 experts in the field of health care management, medical education and health economics to determine the validity of quality of working life questionnaire. The classification of cronbach's α for intra-rater reliability was: very good (0.9-1), good (0.8- 0.89), average (0.7- 0.79), bad (0.6-0.69) and very bad (under 0.59).
Results: The results of  αcronbach test for questions reliability and the result α cronbach test for internal consistency of each class of question indicated the rather high reliability and validity of these questions.
Conclusion: Regarding to the results of α cronbach test, we can deduce that our designed questionnaire encompass have satisfied validity and reliability and it can be used for future studies.

Background and Aim: The aim of this study was structural monitoring of the articles in knowledge and information science field in five Iranian journals. Today, the publication of papers constitutes one of the written scope among scientific broad cost productions.
Materials and Methods: The research method was analytical-survey. The articles were analyzed by the variables such as author distribution by sex, field of study, scientific notation, types of articles by original papers or translated papers, individual or group articles and their publication dates, and by statistical methods used in the articles in two periods from 2002-2006 and 2007-2011.
Results: The results showed that most of the articles were written as original. International cooperation between authors was minimal. Using qualitative research methods among the articles were low. Majority of the authors had masters degree. There was a significant relationship between the authors’ grades, number of authors and journals, and used statistical methods.
Conclusion: The written articles in the field of knowledge and information, followed by special patterns. The journals policies in publication of articles process is the most important issue. Also, lack of international cooperation between Iranian with foreign authors, type and format of the articles were similar according to mentioned variations.

Background and Aim: Cancer is one of the stressful problems of humans life. The concept of cancer will included a complex problems such as cancer pain, physical and psychological, social, and cultural pains. The aim of this study was to determine the relationship between the physical environment of hospital and quality of life in cancer patients.

Materials and Methods: In this mixed study (qualitative – quantitative), 60 cancer patients referred to Imam Khomeini hospital of Ardabil and Shahid Beheshti hospital of Hamadan in 2013 were selected randomly. The data were collected by interview and observation and using the SL-36 quality of life questionnaire and also structured questionnaires was used.

Results: The analysis confirmed that images of natural scenes and artificial plants in hospital rooms increase the quality of life. See watching the outside plant, even outside the room, increase the quality of life.

Conclusion: This study confirms the quality of life increasing properties of natural elements in healthcare environment.

Background and Aim: Cosmetic surgery rhinoplasty, has dramatically been increased during the last two decades. This study aims to explore its effects on the quality of life of individuals gone under the surgery.

Materials and Methods: This was a descriptive and analytical study which was performed as a cross-sectional study. From all plastic surgery clinics in Teheran, 25 clinics were selected randomly as the site of study. In the next step 110 patients undergone rhinoplasty were selected randomly from these clinics. Collected data was analyzed by Spss17.

Results: Findings revealed that, the mean score of quality of life before and after surgery was statistically significant. While mean score of general benefits increased the score of social support and physical health was decreased after the surgery. The most motivating factors for surgery were external factors. In addition there was a positive correlation between quality of life and the time of interview. Also the mean cost of surgery was increased.

Conclusion: Overall quality of life among study population was decreased. It could be because of unnecessary surgeries, medical errors, and etc. The reduction for social support may be resulted from unacceptable consequences of rhinoplasty particularly in terms of appearance. Physical health of respondents was negatively affected by rhinoplastiy surgery. Malfunctions of upper respiratory system after rhinoplastiy surgery is known as the main reason for it. Correlations between the times of surgery and interview suggest a long term assessment of impacts of such surgeries.

Background and Aim: Due to social development, population growth, industrialization of countries and require some work, most of the employees are working with program shift. The purpose of this study was determination of relationship between nurses shift rotation and personality characteristics and coping strategies in selected private hospitals in Tehran, Iran.
Materials and Methods: In this descriptive and cross-sectional study standard shift work questionnaire and Eysenck personality questionnaire was used. After confirming the validity and reliability (Cronbach's alpha 0.73), the questionnaire was distributed among 305 nurses and 6 non-governmental hospitals in Tehran on the cluster random sampling method. Descriptive and analytical methods were used for data analysis using SPSSv.22 software.
Results: 43.6 percent of nurses participating in the study were introverted and 56.4 percent were extroverted. The results showed that there was a meaningful statistical relationship between age and health (p=0.008), gender and physical health (p=0.015), education level and physical health (p=0.014), gender and physical-cognitive anxiety (p=0.006), age and family- socioeconomic status (p=0.001), marital status and family-socioeconomic status (p=0.001), second occupation and family-socioeconomic status (p=0.001). 
Conclusion: Planning according to nurses working hours standard and to avoid overtime, especially nurses who have more experience can prevent severe complications of shift work and improve health and the quality of care. 

Background and Aim: Research in the medical field requires large budgets, specialist human resources and modern equipment and instruments. Scientific collaboration is a way to overcome such problems. Main goal of this study was analyzing scientific collaboration of universities of medical sciences in different aspects.
Materials and Methods: In this research, by using scientometrics methods and social network analysis techniques, the Universities of Medical Sciences co-authorship network was mapped. Source of collecting Data, was Web Of Science database. For mapping and analyzing of scientific networks, we used Bibexcel, VOSviewer, Pajek and UCINET software.
Results: Shahid Beheshti University of Medical Sciences and Tehran University of Medical Sciences, with 933 co-authorship papers are in the first place in scientific collaboration among Iranian Universities of Medical Sciences. And at the international level, Shahid Beheshti University of Medical Sciences has more scientific collaboration than other Iranian universities with the University of Malaya. Tehran University of Medical Sciences, Shahid Beheshti University of Medical Sciences, Isfahan University of Medical Sciences, Tabriz University of Medical Sciences and Shiraz University of Medical Sciences, have significant position in terms of centrality index in co-authorship network.
Conclusion: Medical sciences researchers have very strong tendency to make scientific collaboration with Tehran University of Medical Sciences researchers. For this reason, scientific collaboration network has become a monopoly network around Tehran University of Medical Sciences. This form of collaboration prevents creation of opportunities for collaboration.