F Nabatchian, N Einollahi, N Dashti, Af Sarrafnejad, Ghr Vatani,
Volume 4, Issue 3 (3-2011)
Abstract
Background and Aim: The balance between ROS generation and antioxidant activity is critical to the pathogenesis of oxidative stress related disorders. In this study the prooxidant - antioxidant balance and its correlation with lipid profile and uric acid was determined to evaluate the PAB as a prognostic factor for CAD.
Materials and Methods: Seventy - two patients and sixty eight healthy volunteers were enrolled in this study. The values of PAB were determined by using standard solutions and ELISA method.
Triglyceride, total cholesterol, LDL- cholesterol, HDL - cholesterol and uric acid were measured by enzymatic method.
Results: The PAB values of CAD patients and control group were 70.01±3.36 (HK unit) and 66.40 ± 2.84 (HK unit) respectively. There was no significant difference between PAB values among the two groups (P= 0.41). There was no significant difference between uric acid levels among the two groups (P= 0.46). There was a significant correlation between the uric acid values among patients and healthy volunteers and PAB values (P <0.01). There was a significant correlation between the TG, values among patients and healthy volunteers and PAB values (P<0.05).
Conclusion: This study showed oxidative stress could be used as a significant risk predictor in the coronary artery disease patient
Fariba Nabatchian, Nahid Einollahi, Mohammad Ali Boroomand, Sakineh Abbasi,
Volume 7, Issue 2 (7-2013)
Abstract
Background and Aim: Oxidative interactions such as the formation of oxygen, peroxy radicals and LDL-cholesterol oxidation are involved in the development of atherosclerosis process
This study aims to examine the relationship between serum bilirubin levels and the incidence of coronary artery disease.
Materials and Methods: Eighty-five patients and ninety-two healthy volunteers were enrolled in this study. Total and direct bilirubin levels were measured using diazo method. Besides, triglycerides and total cholesterol were determined by enzymatic method, HDL-Cholesterol by polyanionic method, and LDL-Cholesterol by direct method. For statistical analysis of data, SPSS 17 was applied. For qualitative variables, Chi-square and for quantitative variables, t-student tests were used. The significance level was set at P=0.05.
Results: Direct, indirect and total bilirubin levels were 0.213, 0.375, 0.588 mg/dl for control group and 0.228, 0.365, 0.593 mg/dl for patient group, respectively. No significant difference was observed between the mean values for direct, indirect and total bilirubin in the two groups. Furthermore, there was no significant difference between triglycerides and total cholesterol level figures in the two groups. However, there was a significant difference between HDL-Cholesterol levels (P=0.001), smoking (P=0.031), family history (P=0.006), and mean blood pressure (P<0.001) of the two groups.
Conclusion: The results of this study indicate that measurement of bilirubin as a marker for predicting coronary artery disease may be important. In the end, it should be mentioned that the findings of this study are consistent with some previous studies, but incompatible with others in this area.
Parichehr Hanachi, Zahra Ghaseminya, Khosro Sadeghniyat, Abolfazl Golestani,
Volume 12, Issue 3 (9-2018)
Abstract
Background and Aim: Obstructive sleep apnea (OSA) is one of the most common sleep disorders that, despite the high prevalence, most people are unaware of it. The reason for this disorder is obstruction of the respiratory tract, which reduces blood oxygen as a result of frequent waking during the night. In this study, the status of antioxidant defense was considered as one of the most important mechanisms involved in preventing the consequences of this complication.
Materials and Methods: The 35 subjects of OSA were selected and categorized according to the apnea-hypopnea index (AHI) in two groups: Mild OSA (n=17) and severe OSA (n=18). The fasting blood samples were taken in order to evaluate the antioxidant defense status of the glutathione peroxidase activity (GPx) and glutathione (GSH) content.
Results: The results showed the mean values for GPx in patients with mild and severe apnea were 36.6±2.2 and 35.3±3.7 (u/gHb), respectively. Also, the mean values for GSH content in patients with mild and severe apnea were 0.54±0.1 and 0.68±0.1 µM, respectively that showed a 23% increase (P˂0.05) in severe apnea patients.
Conclusion: There was no significant difference in the GPx activity of mild apnea, however, patients with severe apnea showed a significant increase in GSH levels compared to mild apnea (P<0.05), which may indicate a long-term response to oxidative stress alters gene expression and increases the level of these biomarkers in a long time.
Mina Ahmadi Kakavandi, Kamal Azizbeigi, Seyyed Fardin Qeysari,
Volume 13, Issue 2 (7-2019)
Abstract
Background and Aim: Aging process is associated with increased free radicals and cellular damage. However, resistance training may cause balance of the oxidative and antioxidant system in the elderly. Therefore, the aim of this study was to investigate the effect of eight weeks of progressive resistance training (PRT) on malondialdehyde (MDA) concentration and superoxide dismutase (SOD) enzyme activity in inactive elderly women.
Materials and Methods: 26 inactive elderly women voluntarily participated in present study and divided into progressive resistance training (PRT; n=13) and control group (Con; n=13). The PRT performed resistance training for eight weeks (three sessions per week). Blood samples were collected before and after 8 week of progressive resistance training and analyzed for MDA concentration and SOD activities.
Results: Results showed that after eight weeks of progressive resistance training, MDA concentration significantly decreased in the PRT compared to the control group (p=0.001). Also, SOD activity in the PRT was significantly increased compared to the control group (p=0.002).
Conclusion: The present study showed progressive resistance training cause reduction in malondialdehyde concentration and increase activity of superoxide dismutase that is an important factor in reducing aging process. Therefore, it seems that the regular resistance training causes to balance the oxidant system and reinforcement the antioxidant system in the body and can play a role in preventing serious damage that caused by oxidative stress, especially in aging.
Amin Jalili Sarqaleh, Mohammad Azizi, Kianosh Khamoshyan,
Volume 16, Issue 1 (3-2022)
Abstract
Background and Aim: Multiple Sclerosis is a chronic disease of myelin sheath degradation that reduces the quality of life in patients. Recent studies emphasize on the effect of exercise and natural supplements on the improvement of disease symptoms and quality of life. The aim of this study was to evaluate the effect of eight weeks combined training at home with red grape juice supplementation on quality of life in women with Multiple Sclerosis.
Materials and Methods: In this study, 48 women with MS in the age range of 20-40 years were voluntarily selected and divided into 4 groups: training (n=12), supplement (n=12), training+supplement (n=12) and control (n=12). Combined training included 8 weeks and 3 sessions per week for 60 minutes of endurance and resistance training with an intensity of 10-12 rate of perceived exertion. Subjects consumed 250 cc of grape juice supplement with 68% concentration for 8 weeks, 3 times a week. The control group engaged in their daily activities. Quality of life was measured with standard questionnaire (WHOQOL-BREF) 48 hours before and after the end of the study.
Results: Eight weeks of intervention made a significant change in the quality of life. Based on the correlation t the results were as follows training groups (P=0.001)(7.1%), supplement (P=0.001)(10.5%) and training+supplement (0.000), There was a significant difference between the pre-test and the post-test (P≤0.05). But the changes in the training+supplement group were more than the other groups (P=0.000)(13.3%). In addition, based on the results of one-way analysis of variance, the amount of changes between the groups was also significant (P≤0.05). There was a significant difference between the training group and the control group, supplement group and supplement+training group (P≤0.05). Also, the supplement group had a significant difference with the exercise group and the control group, but there was no significant difference with the supplement + training group (P≥0.05). A significant difference was observed in the supplement+training group with all groups except the supplement group (P≤0.05).
Conclusion: According to the results of the present study, women with Multiple Sclerosis can use combined training at home with red grape juice supplement to improve their quality of life.
