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Showing 4 results for Blood Pressure
Effect of Spirulina Supplementation and Eight Weeks of Combined Exercises on Blood Pressure and Lipid Profile in Women with Hypertension
Elaha Rasouli Jokar, Saeid Shamlou Kazemi, Homa Naderifar,
Volume 17, Issue 2 (5-2023)
Abstract
Background and Aim: High blood pressure and increased lipid profile are risk factors for cardiovascular diseases. To improve cardiovascular health, lifestyle changes should be considered as a guide to reduce people’s inactivity and modify healthy eating patterns. Spirulina is a green alga and has been considered as a food supplement for the treatment of various diseases. This study was conducted with the aim of determining the effect of spirulina supplement and eight weeks of combined exercises on blood pressure and lipid profile in women with high blood pressure.
Materials and Methods: The study was conducted as a clinical trial in 40 women with high blood pressure (50-60 years old). People were included in the study in 4 intervention and control groups. The data were collected during two stages of pre-test and post-test in terms of changes in blood pressure and lipid profile. The supplement intervention group consumed 4.2 grams of spirulina supplement daily and had an exercise intervention of 8 weeks of combined aerobic and resistance exercises. Data analysis was conducted using SPSS software (version 23), one-way analysis of variance (ANOVA) and Tukey’s post hoc test at level 0.05.
Results: The results of ANOVA showed that there was a significant difference between systolic blood pressure, total cholesterol, and VLDL, after the test, in the study groups (P-value<0.05). The highest mean±standard deviation (SD) of systolic blood pressure (141.90±9.85), and total cholesterol (213.30±28.93), after the test, was observed in combined exercise group and the mean± SD of VLDL after the test (34.60±6.46) was observed in the control group. Also, the results of Tukey’s post hoc test showed that there was a significant difference between the mean blood pressure in the control groups-spirulina supplement, control-combined exercises, spirulina supplement-spirulina supplement and combined exercises, and combined exercises-spirulina supplement and combined exercises. Also, there was a significant difference between the mean of total cholesterol and VLDL in combined exercises-spirulina supplement, combined exercises, and control-spirulina supplement groups, respectively (P<0.05).
Conclusion: It seems that the use of spirulina supplement and eight weeks of combined exercises may have beneficial effects on blood pressure and lipid profile in women with high blood pressure.
 

The Effect of a Period of Circuit Resistance Training on Serum Level of Apelin, Vaspin, and Blood Pressure in Elderly Men with Hypertension
Bizhan Hooshmand Moghadam, Shadi Moazami Goudarzi, Amir Rashid Lamir,
Volume 18, Issue 1 (3-2024)
Abstract
Background and Aim: Adipokines imbalance causes pathological effects on this system. Exercise interventions can play an important role in regulating the secretion of adipokines. This study aimed to investigate the effect of 12 weeks of resistance training on the serum level of apelin, vaspin, and blood pressure in elderly men with hypertension.
Materials and Methods: In this quasi-experimental study, 24 elderly men with high blood pressure were selected purposefully and based on the inclusion criteria and were randomly assigned to resistance training (N=12) and control (N=12) groups. The participants of the resistance training group performed resistance training for 12 weeks and three days a week. At the beginning and end of the study, blood samples were collected to measure the serum level of apelin and vaspin. Data analysis was performed using SPSS version 24 software with dependent and independent t-tests at a significant level of less than 0.05.
Results: After 12 weeks of resistance training, there was a significant decrease in the serum level of apelin (P=0.002), vaspin (P=0.01), systolic blood pressure (P<0.001), and diastolic blood pressure (P<0.001) as compared to the pre-test. In addition, a significant difference was observed between the two experimental and control groups in the serum level of apelin (p=0.001), vaspin (P=0.001), systolic blood pressure (P<0.001), and diastolic blood pressure (P<0.001).
Conclusion: It seems 12 weeks of resistance training can improve systolic and diastolic blood pressure and regulate the secretion of adipokines apelin and vaspin in elderly men with high blood pressure.

Design of New Inhibitory ligands Based on Bioenformatic Pharmacophore Modeling in Renin Enzyme for Blood Pressure Control and Treatment
Saeed Pirmoradi,
Volume 18, Issue 5 (11-2024)
Abstract
Background and Aim: One of the ways to control high blood pressure is to deactivate the renin-angiotensinogen-aldosterone RAAS system. Renin, also known as angiotensinogenase,It is a type of enzyme that is produced in the afferent arterioles of the kidney by special cells called juxtaglomerular cells and secreted into the bloodstream and converts angiotensinogen protein into angiotensin type 1, which is very effective in causing high blood pressure. Inhibition of renin as the rate-limiting step of this cycle is an effective way to stop it, which plays a role in the treatment of some diseases related to the heart and blood vessels and blood pressure. The purpose of this study is to use new and different methods based on software to discover newer medicinal compounds with less side effects and cost and in a shorter time to discover based on a reference drug for the treatment and control of blood pressure disease.
Materials and Methods: By selecting the inhibitory reference compound of renin enzyme by bioinformatics tools such as PHARMIT, ZINCPHARMER during virtual search through the structural and pharmacophoretic properties of the reference inhibitory compound, a number of new ligands were obtained. Then the docking process was performed and the selected top ligands in terms of toxicity, allergy, toxicity and ADME prediction were examined with the help of tools such as molsoft, PKCSM, way2drug and swiss ADME.
Results: Among the four final top ligands obtained, one of the ligands had the most interaction with different residues and with a higher docking binding energy (vina score=-9.7) than the others, and then the other two ligands had a favorable binding energy.Among the effective interacting residues, Asp215, Asp32 and Leu114 were bound to renin enzyme in superior ligands, such as the reference compound.
Conclusion: In general, the selected inhibitory ligands showed a good ability to interact with residues involved in substrate selectivity and catalytic activity and inhibition of renin enzyme activity according to the analysis of bioinformatics tools and their confirmation requires clinical studies.

The Evaluation of Relationship of Preoperative Hypertension with Intraoperative Hemodynamic Changes and Early Post-Operative Cardiovascular and Cerebral Complications in Cataract Surgery
Mahdieh Jafari, Majid Razavi, Sepideh Fanaei Nookar, Mehryar Taghavi Gilani,
Volume 19, Issue 1 (4-2025)
Abstract
Background and Aim: Hypertension is one of the most common comorbidities in cataract surgery and severe hypertension sometimes cause surgery to be postponed. The purpose of this study is to evaluate the relationship between preoperative hypertension and intraoperative hemodynamic changes and postoperative early cardiovascular and cerebral complications on cataract surgery.
Materials and Methods: This study was performed on 160 patients with cataract surgery in Mashhad Khatam-al-anbia hospital. Before induction, the patients were divided into three groups by blood pressure measurement: normotensive (blood pressure <140/90) 100 patients, hypertensive (blood pressure 140/90 to 180/110) 30 patients and hypertensive crisis (blood pressure>180/110) 30 patients. Blood pressure and heart rate were assessed before entering to operating room, before induction and every 5 minutes to the end of surgery, after recovery and ward transfer. Cardiovascular and neurological complications were assessed 24 hours after surgery. Data were analyzed by SPSS software. P<0.05 was considered significant.
Results: There was no significant difference between patients for demographic and preoperative hemodynamic parameters. Preinduction, the blood pressure increased compared to the ward, which was more significant in the hypertensive and hypertensive crisis groups (P=0.001). After induction, systolic blood pressure reduced which was more significant in the hypertensive crisis group than two other groups (P=0.001). The heart rate increased after transferring to the operation room and returned to normal after induction of anesthesia, but in three groups were not statistically significant (P=0.25). Systolic blood pressure < 90 mmHg during the surgery, and also cardiovascular and nervous complications up to 24 hours were not significantly different in three groups (P=0.75 and P=0.08, respectively). 
Conclusion: Blood pressure instability was more common in patients with hypertension crisis, but no early or debilitating complications were observed. Primary hemodynamic changes were rapidly reduced and controlled by induction of anesthesia. According to the findings, preinduction blood pressure alone is not sufficient to cancellation of cataract surgery.

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