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Showing 7 results for Therapy
Comparison Of Therapeutic Effectiveness With Clotrimazole 1% Cream With Terbinafine 1% Cream In Patients Therapy Given To Tinea Corporis And Tinea Cruris In Kashan
Rezvan Talaee , Mohammad Dakhili, Mohammad Ali Asadi, Seyed Hamed Sharif Arani, Hossein Akbari, Afshin Salehi ,
Volume 9, Issue 4 (11-2015)
Abstract

Background and Aim: Dermatophytosis is a skin infection without involving of hair, and in fact, Tinea cruris is a form of body Dermatophytosis. For treatment of these two diseases, topical azole or Alylamines are usually used. The aim of this study was to determine the therapeutic effectiveness of Terbinafine 1% and clotrimazole 1%, respectively.

Materials and Methods: 100 patients suspected to Tinea body, and 50 patients direct suspected to Tinea cruris referred to Reference Laboratory of Kashan were selected randomly at one year, prepared smear with 10% KOH, and SCC culture media. 1% cream of Clotrimazole or Terbinafine prescribed 2 and 4 weeks. Then patients recovery was studied for clinical and laboratory results. The data was collected and analyzed by SPSS and Duncan procedure.

Results: After 2 weeks, clotrimazole was more effective than Terbinafine in the treatment of patients infected by Tinea of the body, but equally effective in patients therapy with Tinea cruris By Terbinafine. As a whole, Clotrimazole was more effective than Terbinafine. However, this differences was not significant (P>0/432).

Conclusion: Clotrimazole is our drug choice for therapy of Dermatophytosis and Tinea cruris, in spite of new drugs, for example Terbinafine.


Assessment of Staff Exposure to Radon in Radiotherapy Centers in Tehran, 2015
Arezoo Imani, Fereidoun Mianji , Vahid Changizi, Seyyed Hossein Mousavie Anijdan , Reza Paydar,
Volume 11, Issue 3 (9-2017)
Abstract
Background and Aim: Estimation of radon density  in underground centers is very important. Considering the use of high-energy medical accelerators, radiotherapy departments are usually located in underground floors. The aim of this study was to evaluate staff exposure to radon gas in these centers in Tehran in 2015-2016.
Materials and Methods: This is a descriptive,  cross-sectional survey. In radiotherapy centers of Tehran, 32 radon gas diffusion chamber detectors were installed for a period of 3 months. After collecting the detectors, radon gas concentrations were calculated. The annual effective dose of personnel was evaluated using staff’s working hours per week.  
Results: The minimum and maximum concentrations recorded in this study during one year were 22.14 and 398.52 Bq/m3, respectively, with an average of 87.01 ± 80.68 Bq/m3. Also, radiotherapy personnel’s annual effective dose was 0.34 ± 0.43 mSv per year with the minimum and maximum amounts of 0.02 and 2.35 mSv per year, respectively.
Conclusion: The results indicate that radon level in radiotherapy centers and also that the annual effective dose of personnel in these centers are permissible, and no special action is needed. However, if more attention is paid to certain factors such as air-conditioning, the amount of the gas can even be brought to less than this limit.

The Role of Exosomes in Myeloid and Lymphoid Blood Malignancies: A Systematic Review Article
Asma Maleki, Zahra Kashani Khatib, Shaban Alizadeh, Amir Ali Hamidieh, Ali Akbar Pourfatollah,
Volume 15, Issue 2 (5-2021)
Abstract
Background and Aim: Blood malignancies, one of the most common cancers in the world, cause a large number of deaths each year. Many inherited and acquired factors are involved in the development of this disease. Exosomes are a very small model of cells that are secreted by most cells in the body under physiological and pathological conditions. On the other hand, they have found a special place in the treatment of these diseases because of their very small structure and biodegradability. 
Materials and Methods: This study is a systematic review article. For this study, the electronic databases such as PubMed, Scopus and Web of Science were reviewed and 110 original and review articles were studied from 2000 to 2020. Exosome, blood malignancies and immunotherapy were used as keywords along with a number of other related terms such as tumor microenvironment, acute myeloid leukemia, acute lymphoid leukemia, chronic lymphoid leukemia and multiple myeloma (Exosome AND Leukemia, Leukemia AND Immunotherapy, Exosome AND Cancer, AML AND Exosome) to search in these databases. Finally, 51 sources that related to exosomes and myeloid and lymphoid blood malignancies were used.
Results: The genomic profile of malignant cells and tumor microenvironment changes in the conditions of the disease. The contents of exosomes released by leukemic cells, including anti-apoptotic proteins, various microRNAs, angiogenic agents, heat shock proteins and oncogenes involved in the development of inflammatory phenotype in the target cells, are known as factors involved in the pathogenesis of leukemia. A variety of therapeutic materials such as anti-inflammatory drugs, recombinant proteins, siRNA and the inhibitor of various microRNAs can also be packaged in the exosomes with several ways and used to treat leukemia.
Conclusion: Exosomes derived from malignant cells play the important role in the growth and proliferation, angiogenesis, metastasis, resistance to chemotherapeutic agent, and the escape of cancer cells from the immune system by the modification of tumor microenvironment. The role of exosomes in the creation and development of blood malignancies has been proven. Therefore, using of them will probably be very helpful and promising in the treatment of these disorders with various forms.

Analyzing the Collaboration Network of Global Scientific Outputs in the Field of Bibliotherapy in the Web of Science Database
Soheila Khoeini, Ali Reza Noruzi, Zeinab Jozi, Esmaeil Mostafavi,
Volume 15, Issue 6 (3-2022)
Abstract
Background and Aim: Bibliotherapy is a useful treatment for the prevention and treatment of mental disorders and has led to the formation of many scientific publications in this field. The purpose of this study was to investigate the publication trends in the field of bibliotherapy and visualize the structure of its scientific collaborations based on the Web of Science database during the period 1975 to 2020.
Materials and Methods: The present scientometric study was conducted by citation analysis and social network analysis. The statistical population includes 1032 documents published. HistCite, VOSveiwer, Pajek and UciNet software were used to analyze the data. The co-authorship networks were analyzed and drawn by the VOSviewer software.
Results: U.S., UK, and Australia were ranked first to third with 369, 148, and 91 documents respectively. The documents published by researchers from these three countries have received 10547, 3459, and 3041 citations, respectively. The Universities of Alabama, Nevada, and the Karolinska Institutet in Sweden published the most in this field, with 29, 26, and 21 documents. Scogin F, Cuijpers P, and Rohde P were the most prolific authors with 29, 21, and 17 documents, respectively. Miller WR, Cuijpers P, and Andersson G received the most citations with 2441, 2298, and 1750, citations respectively. UK with 63 degree centrality, U.S. the most influential country with a betweenness centrality of 191.450 and the closeness centrality of the 80 were the most influential countries, and Vrije Universiteit Amsterdam with a betweenness centrality of 1416.755 and a closeness centrality of 658 and the Karolinska Institute with a degree centrality of 43 was the most influential organizations. Rohde P with 39-degree centrality and Cuijpers P with 314.500 betweenness centrality and 821 closeness centrality were the most active author in the co-authorship networks in bibliotherapy. Journal of Clinical Counseling and Psychology was the most cited and the Journal of Poetry Therapy published the most documents.
Conclusion: Paying more attention than before to the cooperation of countries, universities and active authors in the field of bibliotherapy can lead to more knowledge and experience exchange in developed and developing countries.

The Role of Viral and Host miRNAs in The Control, Progression and Possible Treatment of Covid-19 Disease
Alireza Monadi Sefidan, Reza Afrisham,
Volume 16, Issue 3 (8-2022)
Abstract
Background and Aim: Previous studies have shown that viral and host miRNAs play a role in the process of controlling or progressing the disease and can even be considered as therapeutic targets. Accordingly, the present review study was designed to evaluate the role of host miRNAs and Covid-19 virus in the disease process. 
Materials and Methods: The current study was a review study that was conducted during 2012-2022. Studies were extracted from PubMed, Google Scholar, Web of Science and Scopus scientific databases. The researchers selected relevant resources and a summary of them was presented in this review.
Results: The present review study showed that some host miRNAs such as miR-23b-5p, miR-200c, and miR-125a-5p had an inhibitory effect on ACE2 receptor, while miR-3909, miR-4677, and miR-133a had a stimulatory effect on this receptor. Furthermore, host miR-98-5p had an inhibitory effect on TMPRSS2 gene expression. On the other hand, host miR-146a, miR-21, and miR-142 induced inflammation through MAPK and NF-Ƙβ signaling. While, host miR-124, miR-410, and miR-1336 inhibited factor STAT3 and prevented inflammation. Furthermore, host miR-302b and miR-372 targeted the mitochondrial antiviral signaling protein (MAVS), resulting in silencing of type 1 interferon signaling. It has also been established that host exosomal miR-7-5p, miR-24-3p, miR-145-5p, and miR-223-3p inhibited the replication of SARS-CoV-2 and the expression of S protein and their decreased expression in elderly and Diabetic subjects was associated with decreased inhibition of SARS-CoV-2 replication. Moreover, viral miR-359-5p regulated the expression of MYH9 (non-muscle myosin heavy chain 9), which caused virus invasion and release in the host cell.
Conclusion: This study showed that many miRNAs play a role in controlling or progressing the disease of Covid-19 and it is possible to treat the disease of Covid-19 by changing the expression of viral and host miRNA. However, more research is needed in this regard.

Design and Evaluation of Mobile Application to Control Overweight with Cognitive Behavioral Therapy Approach
Niloofar Mohammadzadeh, Negin Ebrahimi, Mojgan Agah Heris,
Volume 16, Issue 4 (10-2022)
Abstract
Background and Aim: According to the report of the World Health Organization, overweight and chronic and psychological diseases caused by it have reached an alarming level in the world. Today, cognitive behavioral therapy as a specific method for controlling overweight teaches the audience how to identify and change inappropriate behavior patterns and destructive thoughts with distress that negatively affect their behavior and emotions. The purpose of this research was to provide a mobile-based application for overweight control with a cognitive-behavioral therapy approach.
Materials and Methods: This research was of applied-developmental type. In the first stage, by examining the available applications based on mobile and related to weight control and also Beck cognitive therapy protocol for weight loss, the capabilities of the application were identified and then based on a survey of experts, these capabilities were determined. Afterwards, the user interface of the application was designed and the necessary coding was done to use it. The database was then created using MySQL software and the application program was created using Flutter software and Dart programming language and was named CBTdiet. Finally, the usability of the application was evaluated by users using a standard QUIS questionnaire.
Results: Based on the entry and exit criteria, among the 247 identified applications, the capabilities of 17 applications were examined. Finally, according to the opinion of the experts, 21 capabilities, including the ability to send motivational messages to the audience and the ability to reward to achieve weight loss of one kilogram per week, were considered for the design of the application program. The application designed in this research was at a good level from the users’ point of view with an average of 7.99±1.1 and was able to obtain an acceptable level of satisfaction in the evaluation stage. The software’s overall capabilities section got the highest average score (8.12) and the screen section got the lowest average score (7.89) among all sections.
Conclusion: Based on the determined capabilities, a mobile-based application for controlling overweight was designed and created with a cognitive behavioral therapy approach, and it can be effective in overweight control by modifying lifestyle and changing destructive thoughts.

Oncolytics, Cancer-Fighting Viruses from Past to Future: A Literature Review
Seyedeh Nasim Mirbahari, Sina Salari, Shabnam Shahrokh, Mohammadreza Zali, Mehdi Totonchi,
Volume 18, Issue 1 (3-2024)
Abstract
Background and Aim: Oncolytic viruses, as novel and advanced tools in the field of treating various types of cancer, have played a very important role in medical developments. The term “oncolytic” refers to the ability of these viruses to destroy and damage cancer cells while preserving the surrounding healthy cells.
Materials and Methods: To conduct this study, a total of 270 initial results were collected through searching in the PubMed, Scopus, and Google Scholar databases from 2012 to 2024. The primary researcher reviewed 68 relevant articles, extracted and summarized the contents, and finally compiled the findings.
Results: The findings from this review study demonstrate that cancer cells possess distinct characteristics that differentiate them from normal cells, including continuous growth signaling, resistance to anti-growth signaling, evasion of apoptosis, increased angiogenesis, and invasion into other body parts. Oncolytic viruses utilize these distinctive features to selectively target and infect cancer cells. Most oncolytic viruses directly eliminate host tumor cells, resulting in viral replication and induction of host antiviral responses. Moreover, these viruses can destroy cancer cells through the production of specific proteins. The cytotoxic potential of oncolytic viruses depends on viral type, genetic manipulation, optimal virus dosage for injection, natural and induced viral tropism, and cancer cell sensitivity to various forms of cell death. The mechanism driving the selective replication of oncolytic viruses in cancer cells likely relates to defects in signaling pathways specific to tumor cells. Phase III clinical trials have demonstrated significant improvements in the treatment outcomes of various cancers, including head and neck cancer, melanoma, glioblastoma, and bladder cancer, through the use of H101 (Oncorine), T-Vec, ECHO-7, and Teserpaturev (Delytact) viruses.
Conclusion: Oncolytic viruses are constructed from various types of viruses and are currently being evaluated in laboratory, preclinical, and clinical stages. The use of these viruses for the treatment of cancer as a new and targeted approach has been proposed, which requires further investigation and achievement of more precise mechanisms for their better performance.

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