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1392/1/25، جلد ۴۲، شماره ۵، صفحات -
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
"INHIBITORY EFFECT OF ALUMINIUM ON KCL AND PHENYLEPHRINE INDUCED CONTRACTION IN ISOLATED RAT AORTA" |
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| چکیده انگلیسی مقاله |
It has been shown in some investigations that cardiovascular events are the main causes of death in hemodialysis patients. The exact etiology is unknown but some of the articles have reported a relation between aluminium ions in the dialysis solution and cardiovascular disorders. To determine the probable effect of aluminium on vasculature function, in vitro effects of aluminium ion on vasoconstriction induced by KCl (30 mM) or phenylephrine (10 µM) were investigated using isolated rat aorta. AlCl3 (1-4 mM) decreased both KCl and phenylephrine induced contractions in a dose dependent manner (P<0.01). Complete inhibition of the contractions occurred using the higher doses of aluminium. Results of this study suggest that because of inhibitory effects of aluminium on vascular contractions, the probable cardiovascular dysfunction must be considered in aluminium intoxication. |
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| کلیدواژه‌های انگلیسی مقاله |
Aluminium, phenylephrine, KCl, vasoconstriction, aorta, |
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| نویسندگان مقاله |
35540---35541--- |
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| نشانی اینترنتی |
http://acta.tums.ac.ir/index.php/acta/article/viewArticle/2781 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Article(s) |
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