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1391/7/29، جلد ۲۶، شماره ۱، صفحات -
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
ABSENCE OF A DEMONSTRABLE EFFECT FOR ENDOTOXIN ON THE LYSOSOMAL ENZYME ACTIVITY OF RECRUITED MACROPHAGES IN A RAT MODEL OF LIVER INJURY |
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| چکیده انگلیسی مقاله |
The endotoxin dose response of recruited and activated tissue macrophages isolated from a rat model of liver injury has been measured after 24 hours in in vitro culture, with respect to their production of a lysosomal enzyme, N-acetyl-glucosaminidase (tlAG). There were no significant differences in the NAG activity in cell lysates or supernatants following a two-hour exposure of the macrophages to a range of endotoxin concentrations (50 ~g. 5 ng./rnl.); nor were any significant differences observed when compared to NAG activity of cells recruited but not exposed to endotoxin. The level of NAG activity in the supernatants and cell lysates of these recruited cells was significantly higher (p<:O.02) than the levels measured in resident macrophages (Kup7.fer cells)isolated from normal rat livers. We conclude that with respect to lysosomal enzyme release these cells have already been maximal.ly activated in vivo and that further hepatic daQage induced by endotoxin .:l.uministration occurs through mechanisms other than increased release of lysosomal enzymes. |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
35923---35924---35925---35926--- |
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| نشانی اینترنتی |
http://acta.tums.ac.ir/index.php/acta/article/viewArticle/174 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Original Article(s) |
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