|
|
1392/9/30، جلد ۵۱، شماره ۱۱، صفحات -
|
|
|
| عنوان فارسی |
|
|
| چکیده فارسی مقاله |
|
|
| کلیدواژه‌های فارسی مقاله |
|
|
| عنوان انگلیسی |
UDP-Glucuronosyltransferase Promoter Polymorphism in Iranian Neonates with Idiopathic Hyperbilirubinemia |
|
| چکیده انگلیسی مقاله |
To determine the association between polymorphism of UGT1A1 gene and idiopathic hyperbilirubinemia in Iranian neonates. Fifty neonates with idiopathic hyperbilirubinemia and Serum total bilirubin (STB) more that 15mg/dl and 50 neonates with idiopathic hyperbilirubinemia and Serum total bilirubin (STB) less than 15mg/dl enrolled in this study. Thymine-adenine (TA) repeats in the promoter region of UGT1A1 gene investigated by means of polymerase- chain reaction (PCR) DNA sequencing. Demographic characteristics did not differ significantly between groups while STB was higher in case group (17.5±1.9 vs. 10.4±1.8, p value <0.001). Among one hundred neonates evaluated in this study, TA6/6, TA6/7 and TA7/7 genotypes found in 52%, 42% and 6%, totally. TA6/7 and TA7/7 genotypes observed in case group more than the control group ( P <0.001). STB levels were significantly higher in cases with TA6/7 and TA7/7 genotype pattern ( P <0.001). Heterozygous and variant homozygous genotypes of the promoter region of UGT1A1 gene in healthy Iranian neonates with idiopathic hyperbilirubinemia should be considered. |
|
| کلیدواژه‌های انگلیسی مقاله |
Idiopathic; Hyperbilirubinemia; Neonate; UDP-glucuronosyltransferase gene |
|
| نویسندگان مقاله |
36056---36057---36058---36059---36060---36061--- |
|
| نشانی اینترنتی |
http://acta.tums.ac.ir/index.php/acta/article/viewArticle/2365 |
| فایل مقاله |
فایلی برای مقاله ذخیره نشده است |
| کد مقاله (doi) |
|
| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
|
| نوع مقاله منتشر شده |
Original Article(s) |
|
|
|
برگشت به:
صفحه اول پایگاه |
نسخه مرتبط |
نشریه مرتبط |
فهرست نشریات
|
