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1391/7/29، جلد ۳۶، شماره ۱، صفحات -
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
EMBRYOTOXIC AND TERATOGENIC EFFECT OF DISODIUM GLYCYRRHETINIC ACID HEMIPHTHALATE IN MICE |
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| چکیده انگلیسی مقاله |
Disodium glycyrrhetinic acid hemiphthalaic (GAP) was evaluated for developmental toxicity in pregnant NMRI mice. GAP was administered intrapcritoneally on days S, 9, 10, of gestation at doses of 0, 25, 50 and 75 mg/kg/dav. On gestation day of IS, after operational delivery, the fetuses were examined for soft tissue, external and skeletal defects. Increased absorptions, dead fetuses, and reduce fetal body weight per litter were observed at doses of 50 and 75 mg/kg/day. In addition by using different doses of GAP at different critical gestation times, developmental delay was observed as reduction in ossification centers and vertebral number in caudal region. It seems that GAP at doses of (50 and 75 mg/kg/day) has a cmbiyotoxic and teratogenic potential in mice. |
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| کلیدواژه‌های انگلیسی مقاله |
Disodium glycyrrhct!@#$%mic acid hemiphthalatc, embryotoxicity, |
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| نویسندگان مقاله |
37160--- |
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| نشانی اینترنتی |
http://acta.tums.ac.ir/index.php/acta/article/viewArticle/674 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Original Article(s) |
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