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1393/2/3، جلد ۲۰۱۴، شماره ۴، صفحات -
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Is the GSTM1 Null Polymorphism a Risk Factor for Primary Angle-Closure Glaucoma among Iranian Population? |
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| چکیده انگلیسی مقاله |
Glutathione S-transferases (GSTs) are members of multigenic family which have essential role in cells as an antioxidant. In the present study we investigated the polymorphism of GSTT1 and GSTM1 deletion genotypes (T0M1, T1M0, and T0M0) in Iranian PCAG (primary closed angle glaucoma) patients compared to healthy subjects. We conducted a study of 41 PCAG patients (24 women, 17 men) and 100 healthy participants (57 women, 43 men) to determine the prevalence of GSTT1 and GSTM1 deletion genotypes and the risk of PCAG, which were determined by multiplex polymerase chain reaction. Genotypes of GSTM1 and GSTT1 null deletions were determined in 22 (53.7%) and 7 (17.1%) patients with PCAG and 34 (34%) and 15 (15%) in healthy participants. Comparison of patients and healthy ones regarding GSTM1 and GSTT1 genotypes revealed increase of GSTM1 null deletions genotypes’ in patients with PCAG ( P =0.03). It was concluded that the increased frequencies of GSTM1 null in patients with PCAG could be associated with a risk factor for incidence of PCAG in the Iranian population. |
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| کلیدواژه‌های انگلیسی مقاله |
GSTM1; Polymorphism; Risk Factor; Angle-Closure Glaucoma; Iran |
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| نویسندگان مقاله |
40457---40458---40459--- |
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| نشانی اینترنتی |
http://acta.tums.ac.ir/index.php/acta/article/viewArticle/4919 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Original Article(s) |
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