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1393/2/3، جلد ۲۰۱۴، شماره ۴، صفحات -
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Association of Adipokine concentration and Myeloperoxidase in Patients with Coronary Artery Disease |
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| چکیده انگلیسی مقاله |
Adipokines, leptin and adiponectin, have a prominent role in the pathogenesis of coronary artery disease (CAD). The inflammatory enzyme, myeloperoxidase (MPO) has also an important role in the pathogenesis of CAD. Association of the adipokine concentration with MPO remains to be resolved in patients with CAD. In this case-control study, 100 patients with CAD and 100 control subjects were appropriately recruited. The presence of CAD was assigned by angiographic evaluation. Plasma leptin, adiponectin and MPO concentrationconcentrations were measured using immunoassay methods. Other conventional cardiovascular risk factors were also recorded. Leptin and MPO concentrations were significantly increased in CAD patients compared to control subjects (25.38 ± 5.91 ng/ml vs. 3.68 ± 1.95 ng/mL and 52.85 ± 12.90 ng/mL vs. 23.00 ± 3.60 ng/mL, p=0.001, respectively). In contrast, adiponectin was significantly decreased in CAD patients compared to control subjects (5.62 ± 1.15 µg/mL vs. 9.25 ± 1.8, P = 0.001). There was a strong positive association between leptin and MPO concentrations only in CAD patients ( P = 0.01). In contrast, a significant inverse association was between adiponectin and MPO in CAD patients ( P =0.01). The associations also were significant after adjustment for other conventional risk factors ( P =0.001). Considering presence of significant association between leptin and MPO, as well as adiponectin and MPO in patients with CAD, it may be inferred that the contribution of the adipokines in the pathogenesis of CAD may be, in part, through affecting the MPO concentrations. |
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| کلیدواژه‌های انگلیسی مقاله |
Adipokines, CAD pathogenesis, leptin, myeloperoxidase |
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| نویسندگان مقاله |
40460---40461---40462---40463--- |
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| نشانی اینترنتی |
http://acta.tums.ac.ir/index.php/acta/article/viewArticle/4928 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Original Article(s) |
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