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1393/2/3، جلد ۲۰۱۴، شماره ۴، صفحات -
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژههای فارسی مقاله |
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| عنوان انگلیسی |
The Neuroprotective Effect of a Triazine Derivative in an Alzheimr’s Rat Model |
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| چکیده انگلیسی مقاله |
Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder. It is characterized by formation of amyloid plaques and neurofibrillary tangles in the brain, degeneration of the cholinergic neurons and neural cell death. This study was aimed to investigate the effect of a triazine derivative, C 16 H 12 Cl 2 N 3 S, on learning in an Alzheimer’s rat model. Animals were divided into seven groups; each group contains 6 animals. Control group: animals received no surgery and treatment; saline group: animals received normal saline after recovery; sham group: animals received 10% DMSO after recovery; STZ group (Alzheimer’s model): animals received streptozotocin (STZ) in four and six days after recovery; T5, T10 and T15 groups: animals were treated with triazine derivative, C 16 H 12 Cl 2 N 3 S, at doses of 5, 10 and 15 µM, respectively. All drugs were injected intracerebroventricular. The spatial learning and histological assessment were performed in all groups. Animals in STZ group had more deficits in spatial learning than control group in Morris water maze. C 16 H 12 Cl 2 N 3 S improved spatial learning significantly compared to STZ group. The CA1 pyramidal layer thicknesses in STZ group reduced significantly compared to control group. C 16 H 12 Cl 2 N 3 S increased the CA1 pyramidal layer thickness in T15 group compared to STZ group. Our findings suggest C 16 H 12 Cl 2 N 3 S may have protective effect on learning deficit and hippocampal structure in AD. |
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| کلیدواژههای انگلیسی مقاله |
Triazine, C16H12Cl2N3S, Learning, Alzheimer’s disease |
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| نویسندگان مقاله |
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| نشانی اینترنتی |
http://acta.tums.ac.ir/index.php/acta/article/viewArticle/5455 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Original Article(s) |
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