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1393/2/3، جلد ۲۰۱۴، شماره ۴، صفحات -
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژههای فارسی مقاله |
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| عنوان انگلیسی |
Considering the prominent complaint as a guide in medical therapy for overactive bladder syndrome in older women |
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| چکیده انگلیسی مقاله |
To evaluate Overactive bladder (OAB) with detrusor overactivity (DOA) following oxybutinin or tolterodine treatment in recommended doses at a four-week course. A total of 100 Iranian women 45 years or older with urgency who also showed idiopathic detrusor overactivity (IDO) in the filling phase of their cystometry were included in current study. In this double-blinded trial two parallel groups were randomized by using two kinds of the antimuscarinic drugs for a four- week course [oxybutinin 5mg, t.d.s. or Tolterodin 2mg, b.i.d.] in alike packages . Data were collected from three-day frequency volume chart (FVC) one month before and after the treatment course. The effectiveness of each drug was compared using the paired, samples t-test. Patients’ improvement regarding urinary urgency, frequency and urge incontinence after treatment in both groups was seen, but mean improvements in the terms of urgency and urge incontinence were larger in patients who were treated by oxybutinin. Night-time frequency was shown to be improved by a significantly larger score by tolterodine. Discontinuation of treatment due to adverse events had no significant difference in two groups. Four week treatment with oxybutinin was better than tolterodine IR in improving urgency and urge incontinence but there were not statistically significant difference between them. In planning a course of treatment especially in the elderly, the difference in the group of symptoms which reduce patients’ quality of life should be considered. Physicians should consider the patients prominent symptom in selection of anti-muscarinic drugs for the treatment of overactive bladder syndrome especially in elderly patients. |
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| کلیدواژههای انگلیسی مقاله |
overactive bladder; oxybutynin; tolterodine, frequency volume chart, urodynamic study |
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| نویسندگان مقاله |
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| نشانی اینترنتی |
http://acta.tums.ac.ir/index.php/acta/article/viewArticle/4941 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Original Article(s) |
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