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1392/1/25، جلد ۴۱، شماره ۲، صفحات -
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژههای فارسی مقاله |
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| عنوان انگلیسی |
"Induction of Thymic HLA-DR signaling with Alpha-smooth muscle Actin expression during the second and third trimesters of gestation " |
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| چکیده انگلیسی مقاله |
Less than 5% of prenatal thymoctes express HLA-DR before week 12 of gestation. However, the number of HLA-DR- positive cells increases during the late second and third trimesters of development. To determine the role of alpha-smooth muscle actin in fetal thymic HLA-DR signaling in different stages of development we examined and compared the immunohistochemical expression of alpha-smooth muscle actin in the myoid cells of the thymic medulla stroma in the 2 nd, and 3rd trimesters of gestation respectively, over the equivalent expression of the protein in the 1 st trimester, in relation with the appearance of HLA-DR-positive thymocytes. Our results demonstrated a quantitative difference in the second and third trimesters of development concerning the expression of alpha-smooth muscle actin in the stromal myoid cells of the thymic medulla over the equivalent expression of the protein in the first (P<0.0001, t-test). Similar changes in the above period wee found concerning the expression of HLA-DR over the first (P<0.0001, test), suggesting a direct involvement of alpha-smooth muscel acting in the sustainence of HLA-DR reactivity. Our data provide evidence that a contractile microfilament alpha-smooth muscle actin plays a pivotal role in HLA-DR expression, through interaction between medullary stromal cells and thymoctes. |
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| کلیدواژههای انگلیسی مقاله |
Medullary thymocytes, HLA-DR signaling, Alpha-smooth muscle actin, Myoid cells, 2nd and 3rd trimesters of gestation, |
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| نویسندگان مقاله |
40862---40863---40864---40865---40866---40867--- |
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| نشانی اینترنتی |
http://acta.tums.ac.ir/index.php/acta/article/viewArticle/2662 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Article(s) |
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