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1387/10/11، جلد ۷، شماره ۴، صفحات -
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عنوان فارسی |
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چکیده فارسی مقاله |
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کلیدواژههای فارسی مقاله |
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عنوان انگلیسی |
A Randomized Controlled Trial of Intravenous Magnesium Sulphate as an Adjunct to Standard Therapy in Acute Severe Asthma |
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چکیده انگلیسی مقاله |
Though intravenous (IV) Magnesium Sulphate (MgS04) has additive effect to beta-2 agonists, its additive benefit in face of combination therapy with beta-2-agonists and ipratropium (standard therapy of severe acute exacerbation of asthma) remains unaddressed. The aim of this investigation was to evaluate the role of IV MgSO4 when used as an adjunct to standard therapy of severe exacerbations of asthma. Randomized, single blinded, placebo-controlled study was carried out in Emergency Department (ED). Patients aged 18-60 years presenting with acute asthma and FEV1 60%pred. and relief in dyspnea at 30, 60, 90, 120 minutes). Both groups of 30 patients each, were matched with respect to demographic and pulmonary parameters (Baseline FEV1% :22.0+5.1% in group2 vs.22.07+5.2% in group1, p=0.87).At 120 minutes, there was a higher mean FEV1 %pred (62.84+4.73% vs. 56.7+4.5%) and %improvement from baseline of (40.7+9.2%vs34.77+7.3%), in group 2 as compared to group1 (Mean Difference= 6.07%, C.I.1.87-10.62., p |
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کلیدواژههای انگلیسی مقاله |
Acute severe asthma, Magnesium sulfate, Treatment |
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نویسندگان مقاله |
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نشانی اینترنتی |
http://ijaai.tums.ac.ir/index.php/ijaai/article/viewArticle/223 |
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زبان مقاله منتشر شده |
en |
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نوع مقاله منتشر شده |
Articles |
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